Chitosan–hyaluronic acid/VEGF loaded fibrin nanoparticles composite sponges for enhancing angiogenesis in wounds

Polyurethane foam containing rhEGF as a dressing material for healing diabetic wounds: Synthesis, characterization, in vitro and in vivo studies

“…Hydrophilic PUs have several strengths, including maintenance of a moist environment, high absorbency for exudates and high moisture permeability. In addition to the synthetic polymers, natural biopolymers including hyaluronic acid, chitosan, and dextran derivatives have been extensively investigated in biomedical applications mainly because of their biocompatibility, non-immunogenicity, biodegradability and cell-adhesion properties [3,[29][30][31][32][33][34]. Among the variety of natural polysaccharides, chitosan is a positively charged linear polysaccharide composed of glucosamine and N-acetyl glucosamine derivatives, has been widely used as a wound dressing material [30].…”

“…Chronic wounds, including arterial ulcers, pressure ulcers, venous ulcers and diabetic foot ulcers, are defined as tissue injuries that do not heal in an orderly set of stages and that also do not heal within 12 weeks [1][2][3][4]. In particular, diabetic foot ulcers are one of the major complications associated with diabetic mellitus.…”

Polysaccharide Based Formulations for Mucosal Drug Delivery: A Review

“…In a recent article, Mohandas and co-workers reported on development of composite chitosan and hyaluronic acid based sponges loaded with fibrin nanoparticles incorporating vascular endothelial growth factor to target multiple phases of wound healing for accelerated therapeutic action in diabetic wounds [253]. They characterised the dressings for porosity, swelling, biodegradation, mechanical properties and haemostatic potential of the sponges whilst release of the growth factor from the sponges were evaluated using ELISA.…”

Advanced Nanostructured Medical Device Combining Mesenchymal Cells and VEGF Nanoparticles for Enhanced Engineered Tissue Vascularization

“…Controlled drugs release is an important field for human health. In most cases, the developed materials for regenerative medicine, using VEGF [40][41][42][43] lead to a high-dose passive release with overdoses, side effect, and the progression of tumors [71], particularly for regeneration of tissues compromised after irradiation. With our double strategy, VEGF release is sustained and dependent of cells adhesion and reliant on their own needs.…”

“…Various studies have reported the development of VEGF loaded nanoparticles for bone regeneration, wound healing angiogenesis, or inhibition of the graft shrinkage [40][41][42][43]. Most of these models can offer a controlled release of VEGF, depending on various parameters (temperature, pH, …).…”