Polyurethane foam containing rhEGF as a dressing material for healing diabetic wounds: Synthesis, characterization, in vitro and in vivo studies

Pyun, Do Gi; Choi, Hwa-Jung; Yoon, Hyoung Soon; Thambi, Thavasyappan; Lee, Sang Soo

doi:10.1016/j.colsurfb.2015.08.029

Cited by 59 publications

(38 citation statements)

References 51 publications

(51 reference statements)

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“…Promising results in chronic wounds care are also associated with other polysaccharide-based hydrogels, such as chitosan [26], hyaluronan [27] and dextran [28]. Similar properties are found in the case of foams that can be applied to wounds with medium exudates [29,30]. An attractive approach in modern wound care is the combination between healing dressings and antimicrobial agents.…”

Section: Wound Care and Dressingsmentioning

confidence: 86%

The importance of oxygen release in diabetic foot ulcer wounds

2019

Bioengineering Int

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Oxygen is the essential element required for proper physiological function of cells, tissues and organs within healthy human body. Thanks to its intricate structure, the skin provides a multiprotective barrier against traumatic and non-traumatic injuries, but also a complex and successful self-healing process of the affected tissue. In the particular case of chronic skin wounds, such as diabetic foot ulcer wounds, there is an immediate demand to develop alternative procedures that prevent infection, speed up healing and eliminate any disrupting factor that may interfere with the therapeutic process. Given the importance of oxygen during wound healing cascade, impressive attention was oriented towards the fabrication of oxygen-releasing wound dressings.

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Section: Wound Care and Dressingsmentioning

confidence: 86%

The importance of oxygen release in diabetic foot ulcer wounds

2019

Bioengineering Int

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“…Additionally, the PU dressing was found to sustain the release of rhEGF for up to 7 days in vitro . Implantation of the rhEGF loaded PU dressing promoted re‐epithelialization and complete recovery of the wound by 21 days in diabetic rats (Pyun do, Choi, Yoon, Thambi, & Lee, ). Based on a previous report that collagen‐binding domain (CBD)‐linked VEGF exhibited high affinity for collagen and retainability at granulation tissue (Yan et al, ), Tan et al () reverse‐applied the concept to develop a collagen scaffold system capable of retaining exogenous VEGF from being washed away by the wound exudates.…”

Section: Biomaterials Systems As Depots For Therapeutics Delivery To Dmentioning

confidence: 99%

Innovations in gene and growth factor delivery systems for diabetic wound healing

Laiva

O’Brien

Keogh

2017

J Tissue Eng Regen Med

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The rise in lower extremity amputations due to nonhealing of foot ulcers in diabetic patients calls for rapid improvement in effective treatment regimens. Administration of growth factors (GFs) are thought to offer an off‐the‐shelf treatment; however, the dose‐ and time‐dependent efficacy of the GFs together with the hostile environment of diabetic wound beds impose a major hindrance in the selection of an ideal route for GF delivery. As an alternative, the delivery of therapeutic genes using viral and nonviral vectors, capable of transiently expressing the genes until the recovery of the wounded tissue offers promise. The development of implantable biomaterial dressings capable of modulating the release of either single or combinatorial GFs/genes may offer solutions to this overgrowing problem. This article reviews the state of the art on gene and protein delivery and the strategic optimization of clinically adopted delivery strategies for the healing of diabetic wounds.

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“…Cross-linked polyurethanes (PUR) are mainly obtained in the reaction of isocyanates with polyols and low-molecular compounds, of which at least one type of reagent is multifunctional [1][2][3]. They can be also synthesized via reaction with using unsaturated compounds [4,5].…”

Section: Podatność Na Degradację Kompozytów Usieciowanych Poliuretanómentioning

confidence: 99%

“…Postęp rozkładu kompozytów oceniano na podstawie zmiany masy, powierzchni i właściwości termicznych próbek. Zarówno zwiększenie zawartości poli([R,S]-3-hydroksymaślanu) w segmencie giętkim poliuretanów, jak i zmieszanie ich z chitozanem spowodowało wzrost podatności usieciowanych poliuretanów na degradację w obu rodzajach roztworów.Słowa kluczowe: usieciowane poliuretany, chitozan, kompozyty, podatność poliuretanów na degradację.Cross-linked polyurethanes (PUR) are mainly obtained in the reaction of isocyanates with polyols and low-molecular compounds, of which at least one type of reagent is multifunctional [1][2][3]. They can be also synthesized via reaction with using unsaturated compounds [4,5].…”

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Degradability of cross-linked polyurethanes/chitosan composites

et al. 2017

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Polyurethanes with synthetic poly([R,S]-3-hydroxybutyrate) in the soft segment and with polycaprolactone triol as cross-linker were blended with chitosan and degraded in hydrolytic and oxidative solutions. Progress of the degradation of the samples was evaluated by changes in their weight, surface topography and thermal properties. Increasing the poly([R,S]-3-hydroxybutyrate) content in soft segment as well as blending with chitosan resulted in an increase in degradability of cross-linked polyurethanes in both solutions.Keywords: cross-linked polyurethanes, chitosan, composites, polyurethane degradability. Podatność na degradację kompozytów usieciowanych poliuretanów z chitozanemStreszczenie: Poliuretany zawierające syntetyczny poli([R,S]-3-hydroksymaślan) w segmencie gięt-kim oraz polikaprolaktonotriol jako związek sieciujący zmieszano z chitozanem i poddano degradacji w roztworach hydrolitycznym i utleniającym. Postęp rozkładu kompozytów oceniano na podstawie zmiany masy, powierzchni i właściwości termicznych próbek. Zarówno zwiększenie zawartości poli([R,S]-3-hydroksymaślanu) w segmencie giętkim poliuretanów, jak i zmieszanie ich z chitozanem spowodowało wzrost podatności usieciowanych poliuretanów na degradację w obu rodzajach roztworów.Słowa kluczowe: usieciowane poliuretany, chitozan, kompozyty, podatność poliuretanów na degradację.Cross-linked polyurethanes (PUR) are mainly obtained in the reaction of isocyanates with polyols and low-molecular compounds, of which at least one type of reagent is multifunctional [1][2][3]. They can be also synthesized via reaction with using unsaturated compounds [4,5]. Cross-linked polyurethanes are not dissolved in the solvent but swelled. With an increase in the degree of cross-linking their elasticity decreases but stiffness increases. They are mainly used as coatings, membrane and shape memory materials [6].Cross-linked polyurethanes are generally less susceptible to degradation than linear polyurethanes. The presence of cross-linkages between chains of polyurethane significantly hinders the migration of water with enzymes, free radicals, and other degradative molecules into the polymer network [6].But, in some cases, the presence of a triol cross-linker in polyurethane structure leads to a polymer with no phase separation. Disordering of the polymer network and reduced mobility of the chains (as a result of chemical cross-linking) allow the ester/ether groups to be exposed to water. In this case cross-linked polyurethanes can be susceptible to degradation [7].The process of degradation of cross-linked polyurethanes can be accelerated by introducing the groups susceptible to degradation (such as ester groups) into their structure or by blending with degradable polymers. Natural polymers or their synthetic analogues (such as polyhydroxybutyrate, polycaprolactone, and chitosan) can be used as part of polyurethane network or as composite fillers.

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Polyurethane foam containing rhEGF as a dressing material for healing diabetic wounds: Synthesis, characterization, in vitro and in vivo studies

Cited by 59 publications

References 51 publications

The importance of oxygen release in diabetic foot ulcer wounds

The importance of oxygen release in diabetic foot ulcer wounds

Innovations in gene and growth factor delivery systems for diabetic wound healing

Degradability of cross-linked polyurethanes/chitosan composites

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