Chitosan grafting onto single-walled carbon nanotubes increased their stability and reduced the toxicity in vivo (catfish) model

Wisdom, K S; Bhat, Irfan Ahmad; Chanu, Thongam Ibemcha; Kumar, Pravesh; Gireesh‐Babu, P.; Nayak, Sunil; Walke, Pravin S.; Sharma, Rupam

doi:10.1016/j.ijbiomac.2020.03.189

Cited by 13 publications

(11 citation statements)

References 31 publications

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“…The FT-IR spectrum of MWCNTs-COOH and PEK-C-OH-g-MWCNTs-COOH can be seen in Figure 2 c. The absorption peaks at 1694 cm −1 and 1625 cm −1 correspond to the C=O and C-O-C stretching vibrations, respectively, which are typical characteristic peaks of MWCNTs-COOH [ 20 , 21 ]. In compared to MWCNTs-COOH, PEK-C-OH-g-MWCNTs-COOH exhibits the characteristic absorption peaks of PEK-C-OH, the peaks at 2925 cm −1 and 2851 cm −1 correspond to C-H vibrations in PEK-C-OH.…”

Section: Resultsmentioning

confidence: 99%

Improved Thermal and Electromagnetic Shielding of PEEK Composites by Hydroxylating PEK-C Grafted MWCNTs

Wen

Chen

et al. 2022

Polymers

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With the rapid rise of new technologies such as 5G and artificial intelligence, electronic products are becoming smaller and higher power, and there is an increasing demand for electromagnetic interference shielding and thermal conductivity of electronic devices. In this work, hydroxyphenolphthalein type polyetherketone grafted carboxy carbon nanotube (PEK-C-OH-g-MWCNTs-COOH) composites were prepared by esterification reaction. The composites exhibited good thermal conductivity, and compared with (MWCNTs-COOH/PEEK) with randomly distributed fillers, (PEK-C-OH-g-MWCNTs-COOH) composites showed a significant advantage, with the same carbon nanotube content, the thermal conductivity of PEK-C-OH-g-MWCNTs-COOH/PEEK (30 wt%) was 0. 71 W/(m-K), which was 206% higher than that of PEEK and 0.52 W/(m-K) higher than that of MWCNTs-COOH/PEEK (26.1 wt%). In addition, the PEK-C-OH-g-MWCNTs-COOH) composite exhibited excellent electrical conductivity and electromagnetic shielding (SE). The SE of 30 wt% PEK-C-OH-g-MWCNTs-COOH/PEEK is higher than the commercially used standard whose value is 22.9 dB (8.2 GHz). Thus, this work provides ideas for the development of thermally conductive functionalized composites.

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Section: Resultsmentioning

confidence: 99%

Improved Thermal and Electromagnetic Shielding of PEEK Composites by Hydroxylating PEK-C Grafted MWCNTs

Wen

Chen

et al. 2022

Polymers

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“…The designed Nonapeptides were procured from Allianz BioInnovation, Mumbai, India. The synthesis and characterization of modified acid-functionalized single-walled carbon nanotube (COOH-SWCNTCS) hybrid are discussed in our previous study (34). The conjugation of nonapeptide with COOH-SWCNTCS hybrid was based on the methods given by Li et al (35).…”

Section: Immobilization Of Nonapeptides With Cooh-swcntcs Hybrid Nano...mentioning

confidence: 99%

“…CNTs are considered a promising vehicle, however, using naked SWCNT alone caused toxicity such as oxidative stress, DNA damage, apoptosis in vivo as well as in vitro ( 33 ). Therefore, due to this reason, the functionalization of CNTs with polymers is necessary to reduce the toxicity of CNTs ( 34 ).…”

Section: Introductionmentioning

confidence: 99%

Teleost Nonapeptides, Isotocin and Vasotocin Administration Released the Milt by Abdominal Massage in Male Catfish, Clarias magur

et al. 2022

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In the present work the nonapeptides i.e., isotocin and vasotocin alone or in a combination were tested in C. magur to evaluate their effect on stripping by abdominal massage. Also, we used chitosan-carbon nanotube nanocomposites to conjugate the nonapetides isotocin (abbreviated as COOH-SWCNTCSPeP) and isotocin and vasotocin (COOH-SWCNTCSPePs) with the aim of sustaining the effect for a longer duration. The conjugation of nonapeptides with nanocomposites was confirmed by Fourier-transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), Thermogravimetric analysis (TGA) and X-ray photoelectron spectroscopy (XPS). Two experiments were conducted to study the effect of naked (without nanoparticles) and conjugated nonapeptides on the milt release by stripping. Both the experiments consisted of eight treatments which included four naked groups two nanoconjugated groups and two controls. Both naked and nonconjugated formulations were successful in stripping the male catfish. The mRNA expression of selected reproductive genes was analysed to decipher the effect of nanopeptides at the molecular level. Nonapeptide treatment either naked or nanoconjugated, resulted in the upregulation of the transcript level of genes. Histological analysis revealed the concentration of spermatozoa was more in peptide injected groups than in the controls. The synergistic effects of nonapeptides and Ovatide had a positive impact on GSI. Thus, the present formulations were successful in stripping the male catfish to obtain the milt with significant reproductive success. Even though the naked groups perform better but the number of males required to fertilize the eggs in nanoconjuagted groups was smaller making it worth using for the delivery of nonapeptides.

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“…The sustained release of compounds complexed with chitosan nanoparticles fulfills the requirements of artificial breeding in fish farming and enable delivery and cell uptake of compounds with low toxicity [121,122]. Chitosan nanoparticles loaded with vitamin C, an important but labile antioxidant, were proven to enhance sustained vitamin C release in the stomach, the intestine and in serum after oral administration in rainbow trout (Oncorhynchus mykiss) [123].…”

Section: Chitosan Loading Chemical Compoundsmentioning

confidence: 99%

Chitosan-Based Drug Delivery System: Applications in Fish Biotechnology

Rashidpour

Pablos

et al. 2020

Polymers

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Chitosan is increasingly used for safe nucleic acid delivery in gene therapy studies, due to well-known properties such as bioadhesion, low toxicity, biodegradability and biocompatibility. Furthermore, chitosan derivatization can be easily performed to improve the solubility and stability of chitosan–nucleic acid polyplexes, and enhance efficient target cell drug delivery, cell uptake, intracellular endosomal escape, unpacking and nuclear import of expression plasmids. As in other fields, chitosan is a promising drug delivery vector with great potential for the fish farming industry. This review highlights state-of-the-art assays using chitosan-based methodologies for delivering nucleic acids into cells, and focuses attention on recent advances in chitosan-mediated gene delivery for fish biotechnology applications. The efficiency of chitosan for gene therapy studies in fish biotechnology is discussed in fields such as fish vaccination against bacterial and viral infection, control of gonadal development and gene overexpression and silencing for overcoming metabolic limitations, such as dependence on protein-rich diets and the low glucose tolerance of farmed fish. Finally, challenges and perspectives on the future developments of chitosan-based gene delivery in fish are also discussed.

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Chitosan grafting onto single-walled carbon nanotubes increased their stability and reduced the toxicity in vivo (catfish) model

Cited by 13 publications

References 31 publications

Improved Thermal and Electromagnetic Shielding of PEEK Composites by Hydroxylating PEK-C Grafted MWCNTs

Improved Thermal and Electromagnetic Shielding of PEEK Composites by Hydroxylating PEK-C Grafted MWCNTs

Teleost Nonapeptides, Isotocin and Vasotocin Administration Released the Milt by Abdominal Massage in Male Catfish, Clarias magur

Chitosan-Based Drug Delivery System: Applications in Fish Biotechnology

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