Chitosan/gellan gum ratio content into blends modulates the scaffolding capacity of hydrogels on bone mesenchymal stem cells

Oliveira, Ariel C. de; Sabino, Roberta M.; Souza, Paulo R.; Muniz, Edvani C.; Popat, Ketul C.; Kipper, Matt J.; Zola, Rafael S.; Martins, Alessandro F.

doi:10.1016/j.msec.2019.110258

Cited by 48 publications

(28 citation statements)

References 40 publications

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“…The thermal behavior of some polysaccharides in solution can be exploited to prepare thermo-responsive hydrogels, including films [ 184 ] and porous materials [ 145 ]. Some carrageenans and gums undergo a coil-to-double helix transition that can induce gelation [ 185 ].…”

Section: Processing Polysaccharide-based Materials For Biomedical Applicationsmentioning

confidence: 99%

“…Chitosan is the unique natural polysaccharide with cationic behavior in aqueous solutions at pH lower than 6.5 [ 208 ]. Chitosan/gellan gum scaffolds created by gelation of polymer blends provide porous structures after the freeze-drying process [ 145 ]. X-ray photoelectron spectroscopy indicated that protonated amino groups occur on the scaffold surface even after the washing step.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…A high water uptake seems to prevent the attachment of cells to the physical assembly. Interconnected pore networks can support vascularization, migration, and proliferation of bone cells; however, the material composition needs to be adjusted to optimize scaffolding capacity [ 145 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…Polysaccharide-based materials often have weak mechanical properties, and chitosan-based assemblies need to be washed to remove residual H 3 O + contents [ 138 , 145 ]. Overall, the mechanical properties of the physical assemblies are improved by associating them with gelatin [ 54 , 195 ], γ-polyglutamic acid [ 225 ], polyethylene oxide [ 195 ], poly(ε-caprolactone) [ 206 , 223 , 224 ], poly(ethylene glycol) [ 229 ], poly(vinyl alcohol) [ 227 , 228 ], polyethyleneimine [ 226 ], and Manuka honey [ 205 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

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Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications

et al. 2021

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Polysaccharide-based materials created by physical processes have received considerable attention for biomedical applications. These structures are often made by associating charged polyelectrolytes in aqueous solutions, avoiding toxic chemistries (crosslinking agents). We review the principal polysaccharides (glycosaminoglycans, marine polysaccharides, and derivatives) containing ionizable groups in their structures and cellulose (neutral polysaccharide). Physical materials with high stability in aqueous media can be developed depending on the selected strategy. We review strategies, including coacervation, ionotropic gelation, electrospinning, layer-by-layer coating, gelation of polymer blends, solvent evaporation, and freezing–thawing methods, that create polysaccharide-based assemblies via in situ (one-step) methods for biomedical applications. We focus on materials used for growth factor (GFs) delivery, scaffolds, antimicrobial coatings, and wound dressings.

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Section: Processing Polysaccharide-based Materials For Biomedical Applicationsmentioning

confidence: 99%

Section: Biomedical Applicationsmentioning

confidence: 99%

Section: Biomedical Applicationsmentioning

confidence: 99%

Section: Biomedical Applicationsmentioning

confidence: 99%

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Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications

et al. 2021

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“…Chitosan (CS) and its cationic derivatives allow the formation of multilayers with the negatively charged heparin (Almodóvar et al, ). CS‐based PEMs can be used to improve the tissue compatibility of surfaces and inhibit bacterial infections (de Oliveira et al, ). Another naturally occurring GAG that has been employed in biomedical materials is hyaluronic acid (HA).…”

Section: Introductionmentioning

confidence: 99%

Enhanced hemocompatibility and antibacterial activity on titania nanotubes with tanfloc/heparin polyelectrolyte multilayers

Sabino

Kauk

Madruga

et al. 2020

J Biomedical Materials Res

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Biomaterial-associated thrombus formation and bacterial infection remain major challenges for blood-contacting devices. For decades, titanium-based implants have been largely used for different medical applications. However, titanium can neither suppress blood coagulation, nor prevent bacterial infections. To address these challenges, tanfloc/heparin polyelectrolyte multilayers on titania nanotubes array surfaces (NT) were developed. The surfaces were characterized by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and water contact angle measurements. To evaluate the hemocompatibility of the surfaces, fibrinogen adsorption, Factor XII activation, and platelet adhesion and activation were analyzed.The antibacterial activity was investigated against Gram-negative P. aeruginosa and Gram-positive S. aureus. Bacterial adhesion and morphology, as well as biofilm formation, were analyzed using fluorescence microscopy and SEM. The anti-thrombogenic properties of the surfaces were demonstrated by significant decreases in fibrinogen adsorption, Factor XII activation, and platelet adhesion and activation. Modifying NT with tanfloc/heparin also reduces the adhesion and proliferation of P. aeruginosa and S. aureus bacteria after 24 hr of incubation, with no biofilm formation. The modified NT surfaces with tanfloc/heparin polyelectrolyte multilayers are a promising biomaterial for use on implant surfaces because of their enhanced blood biocompatibility and antibacterial properties.

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Recent Advances in Polysaccharide‐Based Physical Hydrogels and Their Potential Applications for Biomedical and Wastewater Treatment

Zhang

Yan

Tang

2022

Macromolecular Bioscience

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Polysaccharides are widely employed to fabricate hydrogels owing to their intrinsic properties including biocompatibility, biodegradability, sustainability, and easy modification. However, a considerable amount of polysaccharide‐based hydrogels are prepared by chemical crosslinking method using organic solvents or toxic crosslinkers. The presence of reaction by‐products and residual toxic substances in the obtained materials causes a potential secondary pollution risk and thus severely limits their practical applications. In contrast, polysaccharide‐based physical hydrogels are preferred over chemically derived hydrogels and can be used to address existing drawbacks of chemical hydrogels. The polysaccharide chains of such hydrogel are typically crosslinked by dynamic noncovalent bonds, and the co‐existence of multiple physical interactions stabilizes the hydrogel network. This review focuses on providing a detailed outlook for the design strategies and formation mechanisms of polysaccharide‐based physical hydrogels as well as their specific applications in tissue engineering, drug delivery, wound healing, and wastewater treatment. The main preparation principles, future challenges, and potential improvements are also outlined. It is hoped that this review can provide valuable information for the rational fabrication of polysaccharide‐based physical hydrogel. The specific research works listed in the review can provide a systematic and solid research basis for the reliable development of polysaccharide‐based physical hydrogel.

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Chitosan/gellan gum ratio content into blends modulates the scaffolding capacity of hydrogels on bone mesenchymal stem cells

Cited by 48 publications

References 40 publications

Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications

Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications

Enhanced hemocompatibility and antibacterial activity on titania nanotubes with tanfloc/heparin polyelectrolyte multilayers

Recent Advances in Polysaccharide‐Based Physical Hydrogels and Their Potential Applications for Biomedical and Wastewater Treatment

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