Chitosan-Functionalized Mg0.5Co0.5Fe2O4 Magnetic Nanoparticles Enhance Delivery of 5-Fluorouracil In Vitro

Mngadi, Sanele; Mokhosi, Seipati; Singh, Moganavelli; Mdlalose, W. B.

doi:10.3390/coatings10050446

Cited by 20 publications

(12 citation statements)

References 33 publications

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“…The target-specific delivery of MNPs can be achieved by the process of magnetofection that uses an external magnetic field to guide their delivery. Their application has been extended to magnetic hyperthermia, magnetic resonance imaging (MRI), and delivery systems [78,79]. However, unmodified MNPs are hydrophobic, and can aggregate and generate reactive oxygen species, limiting their in vivo efficacy [80].…”

Section: Nanoparticles and Nanomedicinementioning

confidence: 99%

Nanomedicine for Neurodegenerative Disorders: Focus on Alzheimer’s and Parkinson’s Diseases

Jagaran

Singh

2021

IJMS

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Neurodegenerative disorders involve the slow and gradual degeneration of axons and neurons in the central nervous system (CNS), resulting in abnormalities in cellular function and eventual cellular demise. Patients with these disorders succumb to the high medical costs and the disruption of their normal lives. Current therapeutics employed for treating these diseases are deemed palliative. Hence, a treatment strategy that targets the disease’s cause, not just the symptoms exhibited, is desired. The synergistic use of nanomedicine and gene therapy to effectively target the causative mutated gene/s in the CNS disease progression could provide the much-needed impetus in this battle against these diseases. This review focuses on Parkinson’s and Alzheimer’s diseases, the gene/s and proteins responsible for the damage and death of neurons, and the importance of nanomedicine as a potential treatment strategy. Multiple genes were identified in this regard, each presenting with various mutations. Hence, genome-wide sequencing is essential for specific treatment in patients. While a cure is yet to be achieved, genomic studies form the basis for creating a highly efficacious nanotherapeutic that can eradicate these dreaded diseases. Thus, nanomedicine can lead the way in helping millions of people worldwide to eventually lead a better life.

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Section: Nanoparticles and Nanomedicinementioning

confidence: 99%

Nanomedicine for Neurodegenerative Disorders: Focus on Alzheimer’s and Parkinson’s Diseases

Jagaran

Singh

2021

IJMS

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“…This study demonstrated a promising application of pH/thermos-chemotherapy using an AMF drug delivery system. Mg 0.5 Co 0.5 Fe 2 O 4 MNPs were functionalized using chitosan (CS) coatings to enhance the delivery of the loaded anticancer drug 5-fluorouracil (5FU) for the formation of CS-Mg 0.5 Co 0.5 Fe 2 O 4 -5FU [100]. At physiological pH and under acidic conditions, these small, spherical nanocomposites exhibited stability and sustained drug release for more than 48 h. Furthermore, these exhibited improved and selective anticancer activities compared to the free drug.…”

Section: Biopolymer Coatings On Nanoparticlesmentioning

confidence: 99%

Biopolymer Coatings for Biomedical Applications

Nathanael

2020

Polymers

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Biopolymer coatings exhibit outstanding potential in various biomedical applications, due to their flexible functionalization. In this review, we have discussed the latest developments in biopolymer coatings on various substrates and nanoparticles for improved tissue engineering and drug delivery applications, and summarized the latest research advancements. Polymer coatings are used to modify surface properties to satisfy certain requirements or include additional functionalities for different biomedical applications. Additionally, polymer coatings with different inorganic ions may facilitate different functionalities, such as cell proliferation, tissue growth, repair, and delivery of biomolecules, such as growth factors, active molecules, antimicrobial agents, and drugs. This review primarily focuses on specific polymers for coating applications and different polymer coatings for increased functionalization. We aim to provide broad overview of latest developments in the various kind of biopolymer coatings for biomedical applications, in order to highlight the most important results in the literatures, and to offer a potential outline for impending progress and perspective. Some key polymer coatings were discussed in detail. Further, the use of polymer coatings on nanomaterials for biomedical applications has also been discussed, and the latest research results have been reported.

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“…The most popular drugs for cancer delivery applications, using ferrites as nanocarriers are: Doxorubicin [58], 5-Fluorouracil [21], Docetaxel [76], Hesperidin and Eugenol [60], Curcumin [77], Tamoxifen [55], Cisplatin [78], Nilotinib [79], Camptothecin [38], and Telmisartan [20]. Hydrophobicity of the orally administered drugs for cancer treatments has low systemic bioavailability [80].…”

Section: Nanoferrites Functionalized and Functional Groups For Drug Delivery In Cancermentioning

confidence: 99%

Nanoferrites-Based Drug Delivery Systems as Adjuvant Therapy for Cancer Treatments. Current Challenges and Future Perspectives

Osorio¹,

Herrera²,

Londoño³

et al. 2021

Ferrites - Synthesis and Applications

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Cancer is the second cause of death worldwide, whose treatment often involves chemotherapy. In a conventional therapy, drug is transported (and usually absorbed) across biological membranes through diffusion and systemic transport. The pathway that medicine must travel before reaching the desired location, can bring adverse or unwanted effects, which are mainly the result of: low bioavailability, low solubility and toxicity. To avoiding risks, nanoparticles coated with the drug could be used as a therapeutic substance to selectively reach an area of interest to act without affecting non-target cells, organs, or tissues (drug delivery). Here, the goal is to enhance the concentration of the chemotherapeutic drug in the disease parts of the body. Among all nanostructured systems, ferrites attract worldwide attention in drug delivery applications. It is due to their versatile magnetic and physicochemical properties. Here, it is reviewed and analyzed recent advances in synthesis, morphology, size, magnetic properties, functionalization with a focus in drug delivery applications of nanoferrites.

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Chitosan-Functionalized Mg0.5Co0.5Fe2O4 Magnetic Nanoparticles Enhance Delivery of 5-Fluorouracil In Vitro

Cited by 20 publications

References 33 publications

Nanomedicine for Neurodegenerative Disorders: Focus on Alzheimer’s and Parkinson’s Diseases

Nanomedicine for Neurodegenerative Disorders: Focus on Alzheimer’s and Parkinson’s Diseases

Biopolymer Coatings for Biomedical Applications

Nanoferrites-Based Drug Delivery Systems as Adjuvant Therapy for Cancer Treatments. Current Challenges and Future Perspectives

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