Chitosan film enriched with an antioxidant agent, taurine, in fenestration defects

Abstract

A natural polysaccharide, chitosan (poly-N-acetyl glucosaminoglycan), which is a nontoxic and bioabsorbable polymer, has been shown to have hemostatic and antibacterial effects. An amino acid, taurine, is considered to be beneficial for regulating the inflammation process. The purpose of this study was to investigate the synergistic effects of taurine and chitosan in the experimental defects at the vestibular bone of maxillary canine teeth in six dogs. Chitosan films were prepared as delivery system with or without taurine and placed in the randomly chosen defects. Biopsies were performed on the postoperative seventh day and routine histological procedures were performed for light and electron microscopic evaluations. For each group, 30 different microscopic areas were examined and the numbers of macrophages and neutrophils in these areas were counted. The mean numbers of both macrophages and neutrophils were found statistically different between the chitosan film incorporated with taurine and free chitosan groups (p < 0.0001 p > 0.05). In addition to the increase in cell counts in both groups, the cytological alterations were more obvious in the chitosan film group incorporated with taurine. Accordingly, taurine appears to enhance the acceleration effect of chitosan on wound healing at early periods. This effect could be considered beneficial in tissue repair in destructive diseases like periodontitis.

A novel injectable thermoresponsive and cytocompatible gel of poly(N-isopropylacrylamide) with layered double hydroxides facilitates siRNA delivery into chondrocytes in 3D culture

“…However, another biomaterial subcutaneously inducing a similar mixed macrophage and neutrophil response [52,53], chitosan, has been successfully applied in vivo for articular cartilage regeneration [54], suggesting also intra-articular application of the LDH-pNIPAAM gels would be feasible.…”

Possibility of combined system enzyme therapy and antioxidants in treatment of periodontal and oral mucosa diseases

“…Важ-ная причина их возникновения и развития -сбой в си-стеме регуляции окислительно-восстановительных пре-вращений и в первую очередь нарушение соотношения анти-, прооксидантных и детоксикантных систем. При этом начальные этапы запуска свободнорадикальных окислительных процессов при разных патологических со-стояниях могут различаться, но в последующем их на-правленность и интенсивность теряют специфичность и зависят от состояния и степени мобилизации антиокси-дантной и детоксикантной защиты [7,8,22,39,41].…”

“…Так, весьма пер-спективны металлокомплексы ряда жизненно важных элементов на основе азольных лигандов, которые прини-мают активное участие в разнообразных ферментативных процессах и связывании микроэлементов в живых орга-низмах. Эти «координационные» соединения, обладая широким спектром направленного действия, способству-ют стабилизации гомеостаза, малотоксичны, легкодози-руемы и, что самое важное -высокоэффективны [3,7,8,31,39].…”

Controlled-release of tetracycline and lovastatin by poly(D,L-lactide-co-glycolide acid)-chitosan nanoparticles enhances periodontal regeneration in dogs

“…15 Metronidazole-loaded chitosan microparticles were successfully prepared by an emulsion cross-linking method and might be suitable for future periodontitis treatment. 16 A clinical study reported that chitosan gel incorporated with or without 15% metronidazole was effective in probing depth reduction in patients with chronic periodontitis.…”