Chitosan bearing pendant cyclodextrin as a carrier for controlled protein release

Synthesis and characterization of novel drug delivery system using modified chitosan based hydrogel grafted with cyclodextrin

“…The coupling reaction was carried out using (CS-MNP)-g-poly(AA) (1.0 g) and en-β-CD (0.5 g), which were dissolved in water/DMF mixture with stirring at 0 o C. After 1 h, EDC (0.96 g) and HOBt (0.67 mg) were added to above solution and further stirred at 0 o C for 4 h, then at room temperature for 48 h. pH of the solution was adjusted to 2.0 by the addition of HCl and dialyzed against distilled water for 5 days and freeze dried [26].…”

“…The mixture was stirred and heated to reflux under nitrogen atmosphere for 24 h. After evaporation, the mixture was poured into vigorously stirred ethanol (500 mL) and stored in a refrigerator to produce slight yellow precipitate. The solid product was collected by filtration and purified by column chromatography on a hydroxymethyl cellulose column [26].…”

“…Chitosan-graft-β-CD nanoparticles as a carrier for controlled release of ketoprofen were investigated in detail by Yuan et al [20]. CS bearing pendant CD as a carrier for controlled protein release was done by Zhang et al [21]. So many workers have reported several drug delivery systems for the drug, CUR.…”

Self-aggregates formation and mucoadhesive property of water-soluble β-cyclodextrin grafted with chitosan

“…The main reason for the interest of CD-g-CS is on increased contact to the biological substrate and localisation in specified regions to improve and enhance the bioavailability of the drug in DDS [11]. However, main applications of the CD-g-CS can only be investigated in acidic media because of its poor solubility in water [11][12][13]. To solve this problem, the water-soluble quaternized ␤-cyclodextrin grafted with CS (QCD-g-CS) was previously synthesized and characterized by our research groups.…”

pH-responsive glycol chitosan-cross-linked carboxymethyl-β-cyclodextrin nanoparticles for controlled release of anticancer drugs

“…14, 20 Wang et al 21 used β-CD-modified CS-poly(acrylic acid) NPs to encapsulate the anticancer drug paclitaxel. These NPs showed enhanced paclitaxel solubility in aqueous solution.…”