Chitosan based surfactant polymers designed to improve blood compatibility on biomaterials

Sagnella, Sharon M.; Mai-ngam, Katanchalee

doi:10.1016/j.colsurfb.2004.07.001

Cited by 139 publications

(71 citation statements)

References 26 publications

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“…Surfaces with different textured structures could cause water-repellency, and were considered to be anti-adhesive [13]. The surface hydrophobicity was responsible for less protein adsorption and less cellular adhesion, resulting in improved biocompatibility [14][15]. In addition, the wettability of these surfaces which was measured by contact angle meter was related to the result of platelet adhesion.…”

Section: Introductionmentioning

confidence: 99%

Blood Platelet’s Behavior on Nanostructured Superhydrophobic Surface

Zhou

Yang

Xia

et al. 2008

JNanoR

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Abstract. Regular arrays of micro-pillars and nano-grooves structures on the silicon wafer are fabricated by using soft lithography, and the three dimension morphology of textured surface is observed by using scanning electron microscopy (SEM) and atomic force microscope (AFM). The static water contact angles are measured by using contact angle meter to characterize the wettabilities of these surfaces. To investigate how the presence of topography and the variations of wettability affect the haemocompatibility of textured surface contacted with blood, different patterned surfaces are designed and fabricated, and blood platelet adhesion test is carried out on these surfaces. The adhesion and coagulation of platelets are inspected by scanning electron microscopy (SEM). Experimental data presented in this paper indicate that different surface roughness and wettability are the important factors for blood platelet adhesion. The amount of adsorbed blood platelet is low on textured surfaces, compared with that on the flat surface. Especially, there is no coagulation and activation on the surface with nanometer grooves. That is to say, the superhydrophobic surface is apt to decrease blood platelet adhesion. The study suggests that surface with suitable wettabililty and textured structures exhibits superior blood compatibility.

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Section: Introductionmentioning

confidence: 99%

Blood Platelet’s Behavior on Nanostructured Superhydrophobic Surface

Zhou

Yang

Xia

et al. 2008

JNanoR

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“…Water absorption test was performed to predict the size of the substance that can diffuse through the membrane material. When the membrane expands, the mobility of the polymer chains increases, thus facilitating solvent penetration to fill the [11,15]. The presence of -COOH groups in the cross-link structure led to increased interaction between the water with polymers.…”

Section: Water Absorption Of the Membranesmentioning

confidence: 99%

“…The results from the analysis were then compared to the theoretical percentage calculated by assuming that crosslinking reaction occur between 2 chitosan monomers and 1 citric molecule as displayed in Table 1. The data displayed in Table 1 indicates the increase of surface carbon elemental concentration from CS to CA.cl.CS indicated that the crosslinking reaction has occurred between chitosan and citric acid [15].…”

Section: Permeation Studymentioning

confidence: 99%

Preparation of Citric Acid Crosslinked Chitosan/Poly(Vinyl Alcohol) Blend Membranes for Creatinine Transport

2018

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“…As the membrane expands, the mobility of the polymer chain increases to facilitate the penetration of the solvent, in addition to the small ions trapped within the diffused membrane leaving the membrane thus providing a greater opportunity for the solvent to fill in the abandoned empty spaces. The development of the chitosanalginate membrane is probably due to the ionic interaction between the NH 3+ group of chitosan and the COO ions of the membrane alginate (Dash et al, 2011; Sagnella andMaiNgam, 2005). The blend membranes usually exhibited higher wáter absorption degree then the chitosanpectin membrane (255%) (Ayuni, 2013), indicating a more flexible membrane structure (Huangfu et al, 2009; Gao et al, 2014.…”

Section: Water Uptakementioning

confidence: 99%

Study of Creatinine Transport through Chitosan/Pectin/Poly(Vinyl Alcohol) Blend Membranes

Ayuni

Yuningrat

2017

Indones. J. Biotechnol.

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Creatinine was final product of creatine metabolism inskeletal muscle. Increasing of creatinine showed decreasing of kidney function. Kidney fuction decreased could be treated by hemodialysis (HD). One of the natural polymer was cellulose which often used as hemodialysis membrane. Chitosan as natural membrane was used as membrane in this research because the structure was almost similar to cellulose. Chitosan was complexed by pectin and poly(vinil alcohol) (PVA) to fixed mechanical characteristic of membrane. The objective of this research were to synthesize, characterize, and know efficiency of creatinine transport using chitosan/pectin/PVA blend membranes. The functional groups of synthesized membrane were characterized by FTIR spectrophotometer. Efficiency of optimum creatinine transport was known by using membrane with chitosan and pectin ratio70:30 while PVA used 0.5%; 1.0% and 1.5%. The source and acceptor phase resulted were complexed by picric acid and analyzed by Ultraviolet-Visible (UV-Vis) Spectrophotometer. The result of membrane synthesized which was analyzed by FTIR Spectrophotometer shows that there is a band broadening on wave number 3448.72 cm-1. It is indicated that there are an overlapped stretching of hydrogen bond -OH on PVA and NH2 on chitosan. The optimum creatinine 70 ppm transported using membrane with 1.5% PVA addition is 59%.

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Chitosan based surfactant polymers designed to improve blood compatibility on biomaterials

Cited by 139 publications

References 26 publications

Blood Platelet’s Behavior on Nanostructured Superhydrophobic Surface

Blood Platelet’s Behavior on Nanostructured Superhydrophobic Surface

Preparation of Citric Acid Crosslinked Chitosan/Poly(Vinyl Alcohol) Blend Membranes for Creatinine Transport

Study of Creatinine Transport through Chitosan/Pectin/Poly(Vinyl Alcohol) Blend Membranes

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