Blood Platelet’s Behavior on Nanostructured Superhydrophobic Surface

Abstract

Abstract. Regular arrays of micro-pillars and nano-grooves structures on the silicon wafer are fabricated by using soft lithography, and the three dimension morphology of textured surface is observed by using scanning electron microscopy (SEM) and atomic force microscope (AFM). The static water contact angles are measured by using contact angle meter to characterize the wettabilities of these surfaces. To investigate how the presence of topography and the variations of wettability affect the haemocompatibility of textured surface contacted with blood, different patterned surfaces are designed and fabricated, and blood platelet adhesion test is carried out on these surfaces. The adhesion and coagulation of platelets are inspected by scanning electron microscopy (SEM). Experimental data presented in this paper indicate that different surface roughness and wettability are the important factors for blood platelet adhesion. The amount of adsorbed blood platelet is low on textured surfaces, compared with that on the flat surface. Especially, there is no coagulation and activation on the surface with nanometer grooves. That is to say, the superhydrophobic surface is apt to decrease blood platelet adhesion. The study suggests that surface with suitable wettabililty and textured structures exhibits superior blood compatibility.

Competitive adsorption of fibrinogen and albumin and blood platelet adhesion on surfaces modified with nanoparticles and/or PEO

“…A few studies reported the influence of surface nanostructure on platelet adhesion (see Section 1 and Refs. [35][36][37][38][39][40][41]). The surface topography produced here by colloidal lithography could increase the contact area with the platelets if the latter were able to deform in order to follow the surface relief.…”

“…A few attempts to influence platelet adhesion through substrate nanostructuration have been reported [35][36][37][38][39][40][41]. Platelet adhesion was decreased or increased by the presence of nanogrooves at the surface of poly(dimethyl siloxane) [38] or poly(caprolactone) [37], respectively. Vertically aligned carbon nanotubes, associated with a polymer matrix, were used to reduce platelet adhesion [36,41].…”

“…More recently, nanoscale topography appeared to affect the morphology of different cells, such as fibroblasts and osteoblasts [31][32][33][34]. A few attempts to influence platelet adhesion through substrate nanostructuration have been reported [35][36][37][38][39][40][41]. Platelet adhesion was decreased or increased by the presence of nanogrooves at the surface of poly(dimethyl siloxane) [38] or poly(caprolactone) [37], respectively.…”

Fabrication and Medical Applications of Lotus-leaf-like Structured Superhydrophobic Surfaces

“…Zhou et al found a novel strategy for the significant improvement of the blood compatibility of nanostructured trichloro (1H,1H,2H,2H-perfluorooctyl)silane on silicone ( Figure 6). 76 Mao et al…”

Reduced platelet adhesion and improved corrosion resistance of superhydrophobic TiO2-nanotube-coated 316L stainless steel

“…TNTs are usually superhydrophilic [24,35], and can greatly improve hemocompatibility or corrosion resistance as discussed above. On the other hand, superhydrophobic materials have also been reported to improve either hemocompatibility [24,[37][38][39][40] or corrosion resistance [41,42]. Thus, both superhydrophobic and superhydrophilic TNTs could be promising coatings for blood contact materials such as SS.…”