Chitosan-based silver nanoparticles: A study of the antibacterial, antileishmanial and cytotoxic effects

Lima, Douglas dos Santos; Gullón, Beatriz; Cardelle‐Cobas, Alejandra; Brito, Lucas Moreira; Rodrigues, Klinger Antônio da França; Quelemes, Patrick Veras; Ramos‐Jesus, Joilson; Arcanjo, Daniel Dias Rufino; Plácido, Alexandra; Batziou, Krystallenia; Quaresma, Pedro; Eaton, Peter; Delerue–Matos, Cristina; Carvalho, Fernando Aécio de Amorim; Silva, Durcilene Alves da; Pintado, Manuela; Leite, José Roberto S. A.

doi:10.1177/0883911516681329

Cited by 44 publications

(25 citation statements)

References 49 publications

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“…This observation commonly occurs because DLS is a more sensitive method that can measure large and small particles as well as aggregates in a solution, whereas TEM may measure certain particles only due to possibility of biasness during sample preparation. 26 In addition, in this study, the use of chitosan as a capping agent may have increased the hydrodynamic diameter relative to the size of the inorganic core, as shown previously. 27…”

Section: Morphologysupporting

confidence: 66%

Antimicrobial activity of multifaceted lactoferrin or graphene oxide functionalized silver nanocomposites biosynthesized using mushroom waste and chitosan

et al. 2020

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Section: Morphologysupporting

confidence: 66%

Antimicrobial activity of multifaceted lactoferrin or graphene oxide functionalized silver nanocomposites biosynthesized using mushroom waste and chitosan

et al. 2020

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“…Non‐cyclic polyesters with monomethoxy polyethyleneoxide (mPEO) have potential applications in drug release systems. Polylactate polymers are known as biodegradable and biocompatible polymers . When joined with mPEO they become potential supplements in drug delivery systems .…”

Section: Need For Chemical Modifications Of Phasmentioning

confidence: 99%

“…Polylactate polymers are known as biodegradable and biocompatible polymers. 86 When joined with mPEO they become potential supplements in drug delivery systems. 55 A diblock copolymer PHB-b-mPEO was successfully synthesized and showed the capability to self-assemble into nanoparticles and could be used in drug delivery systems and as carriers.…”

Section: Esterification Of Phasmentioning

confidence: 99%

Polyhydroxyalkanoates: Properties and chemical modification approaches for their functionalization

Raza

Riaz

Banat

2017

Biotechnology Progress

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Polyhydroxyalkanoates (PHAs) have become an attractive biomaterial in research in the past few years due to their extensive potential industrial applications. Being long chain hydroxyl fatty acid molecules, the PHAs are hydrophobic in nature, and have less functional groups. These features limit their applications in various areas. To enhance their usage, these polymers may need to be modified including surface and chemical modifications. Such modifications may alter their mechanical properties, surface structure, amphiphilic character and rate of degradation to fulfil the requirements for their future applications. Chemical modifications allow incorporation of functional groups to PHAs that could not be introduced through biotechnological methods. These chemically reformed PHAs, with enhanced properties, could be used for broad range of applications. This review aims to introduce different chemical modification approaches including some recent methods that had not been explored or discussed so far for PHAs as possible technologies for widening the range of product and application potentials. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 34:29-41, 2018.

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“…In 2017, a study carried out in Brazil revealed the antileishmanial activity of chitosan which opened a path for drug development. Scienti c researchers could use chitosan polymers as a pharamacological tool for treating leishmaniasis that lessen the required dose as well as the side effects caused by conventional drug (Lima et al, 2017) The drugs contain chemical compounds that may induce a hemolytic effect and many drugs have severe adverse effects on erythrocytes. In this experimentation, hemolysis assay was performed to examine the hemolytic activity of synthesized nanoparticles.…”

Section: Discussionmentioning

confidence: 99%

A novel effective therapeutic approach for treatment of Leishmania tropica through Miltefosine Loaded Chitosan Nanoparticles

Khan

Shereen

Khokhar

et al. 2020

Preprint

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Objectives The aim of the present study was to develop miltefosine loaded chitosan nanoparticles (MLCNPs) to enhance the therapeutic efficacy of conventional miltefosine drug and to compare the in vitro activities of both forms of the drug against Leishmania tropica. Methods MLCNPs were synthesized through ionic gelation with sodium tripolyphosphate (TPP). For the stabilization of nanoparticles, a controlled oxidation of MLCNPs was done with hydrogen peroxide (H2O2). The anti-leishmanial activities of MLCNP were determined by MTT cell viability colorimetric assay. The in vitro hemolysis assay was performed for assessment of toxicity in the human blood. Results The MLCNPS displayed spherical shape with irregular surface morphology, had a mean size of 200nm and a zeta potential of +10.9 ± 4 mV. A high encapsulation efficacy and drug loading capacity of miltefosine loaded chitosan nanoparticles was also observed. The anti-leishmanial activities of MLCNP were determined by MTT cell viability colorimetric assay. The IC50 value of MLCNPs against promastigote and amastigote were recorded as 0.85µg/ml and 0.92µg/ml respectively. MLCNPs proved to be more effective as compared to conventional miltefosine. In terms of toxicity the MLCNPs caused only 2.25% hemolysis. Conclusions The engineered MLCNPs could be potential alternative for the treatment of cutaneous leishmaniasis.

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Chitosan-based silver nanoparticles: A study of the antibacterial, antileishmanial and cytotoxic effects

Cited by 44 publications

References 49 publications

Antimicrobial activity of multifaceted lactoferrin or graphene oxide functionalized silver nanocomposites biosynthesized using mushroom waste and chitosan

Antimicrobial activity of multifaceted lactoferrin or graphene oxide functionalized silver nanocomposites biosynthesized using mushroom waste and chitosan

Polyhydroxyalkanoates: Properties and chemical modification approaches for their functionalization

A novel effective therapeutic approach for treatment of Leishmania tropica through Miltefosine Loaded Chitosan Nanoparticles

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