Antimicrobial activity of multifaceted lactoferrin or graphene oxide functionalized silver nanocomposites biosynthesized using mushroom waste and chitosan

Abdalla, Sundos Suleman Ismail; Katas, Haliza; Chan, Jie Yee; Ganasan, Pavitra; Azmi, Fazren

doi:10.1039/c9ra08680c

Cited by 38 publications

(30 citation statements)

References 67 publications

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“…AgNPs also have strong affinity towards the sulfur-containing proteins in the microbial cell wall. The attachment of AgNPs towards the membrane of microbes causes irreversible morphological changes in the structure of cell membrane [65]. This can also cause a loss in the integrity of lipid bilayer and the permeability of the cell membrane.…”

Section: Antibacterial Properties Of Agnpsmentioning

confidence: 99%

The Potential of Silver Nanoparticles for Antiviral and Antibacterial Applications: A Mechanism of Action

et al. 2020

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Rapid development of nanotechnology has been in high demand, especially for silver nanoparticles (AgNPs) since they have been proven to be useful in various fields such as medicine, textiles, and household appliances. AgNPs are very important because of their unique physicochemical and antimicrobial properties, with a myriad of activities that are applicable in various fields, including wound care management. This review aimed to elucidate the underlying mechanisms of AgNPs that are responsible for their antiviral properties and their antibacterial activity towards the microorganisms. AgNPs can be synthesized through three different methods—physical, chemical, and biological synthesis—as indicated in this review. The applications and limitations of the AgNPs such as their cytotoxicity towards humans and the environment, will be discussed. Based on the literature search obtained, the properties of AgNPs scrutinizing the antibacterial or antiviral effect shown different interaction towards bacteria which dependent on the synthesis processes followed by the morphological structure of AgNPs.

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Section: Antibacterial Properties Of Agnpsmentioning

confidence: 99%

The Potential of Silver Nanoparticles for Antiviral and Antibacterial Applications: A Mechanism of Action

et al. 2020

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“…The combination of Ag and GO is also proved to reduce the agglomeration of Ag NPs. GO is a two-dimensional material made up of a single hexagonally arranged layer of sp 2 -bonded carbon atoms with large surface areas and numerous oxygen-containing functional groups such as hydroxyl, epoxy, and carbonyl groups protruding from GO backbones, which make the GO more hydrophilic [ 165 , 166 ]. Thus, it offers excellent dispersion of NPs on the edges of its planes through chemical bonding even at high concentrations.…”

Section: Nanotechnology-based Antimicrobial Applicationsmentioning

confidence: 99%

“…Xiang et al proposed a method to boost the antimicrobial action of titanium (Ti) implants through coating with poly(lactic-co-glycolic acid)/ZnO nanorods/Ag NPs and their results revealed that the cytotoxicity of PLGA-ZnO-AgNPs was lower than ZnO and ZnO-Ti against mouse preosteoblasts (MC3T3- E1) cells [ 166 ]. In another study, Ti alloy (Ti6Al4V) dental implants were coated with Ag NPs, together with hydroxyapatite (HA) and 3 samples were prepared: Ti6Al4V with Ag NPs, Ag NPs plus HA microparticles (Ag+mHA), or Ag NPs plus HA NPs (Ag+nHA) [ 157 ].…”

Section: Biocompatibility Of Nanoparticlesmentioning

confidence: 99%

Current approaches for the exploration of antimicrobial activities of nanoparticles

Rosli

Teow

Mahmoudi

2021

Science and Technology of Advanced Materials

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is currently pursuing a master's degree at Universiti Kebangsaan Malaysia (UKM). Her research focuses on the antimicrobial of nanoparticles for application in the industry. Dr. Teow Yeit Haan is a senior lecturer at UKM. Her expertise includes membrane synthesis and characterization, membrane application for water purification and wastewater treatment, membrane fouling, water disinfection technology, and adsorption. She had published more than 44 research articles, 22 conference proceedings, and 3 book chapters. Dr. Ebrahim Mahmoudi is working as a senior lecturer at UKM. He is researching separation and purification using polymeric membranes and membrane bioreactors. Current Approaches for the Exploration of Antimicrobial Activities of NanoparticlesInfectious diseases of bacterial and viral origins contribute to substantial mortality worldwide. Collaborative efforts have been underway between academia and the industry to develop technologies for a more effective treatment for such diseases. With their utility in various industrial applications, nanoparticles (NPs) offer promising potential as antimicrobial agents against bacterial and viral infections. NPs have been established to possess potent antimicrobial activities against various types of pathogens due to their unique characteristics and cell-damaging ability through several mechanisms. The recent accepted antimicrobial mechanisms possess by NPs include metal ion release, oxidative stress induction, and non-oxidative mechanisms. Another merit of NPs lies in the low likelihood of the development of microbial tolerance towards NPs,given the multiple simultaneous mechanisms of action against the pathogens targeting numerous gene mutations in those pathogens. Moreover, NPs provide a fascinating opportunity to curb microbial growth before infections: this outstanding feature has led to their utilization as active antimicrobial agents in different industrial applications, e.g. the coating of medical devices, incorporation in food packaging, promoting wound healing, and encapsulation with other potential materials for wastewater treatment. This review discusses the progress and achievements in the antimicrobial applications of NPs, factors contributing to their actions, mechanisms underlying their efficiency, and risks of their applications, including the antimicrobial action of metal nanoclusters (NCs).The review concludes with a discussion of the restrictions in present studies and future prospects of nanotechnology-based NPs development.

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“…5 Recently, LTF has been attached onto the surface of biosynthesized AgNPs by which reduction of silver ions to AgNPs was achieved using a spent mushroom substrate (SMS, a mushroom waste after harvesting). 6 The resulting Ag-LTF was also capped with chitosan for nanoparticle stabilization and biocompatibility enhancement. In this study, Ag-LTF had higher antibacterial activity against selected bacterial strains as than their single components.…”

Section: Introductionmentioning

confidence: 99%

“…In this study, Ag-LTF had higher antibacterial activity against selected bacterial strains as than their single components. 6 This has led to the development of a carrier for Ag-LTF, to be used as a dressing for infected wound treatment.…”

Section: Introductionmentioning

confidence: 99%

Gelatin Hydrogels Loaded with Lactoferrin-Functionalized Bio-Nanosilver as a Potential Antibacterial and Anti-Biofilm Dressing for Infected Wounds: Synthesis, Characterization, and Deciphering of Cytotoxicity

et al. 2021

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Gelatin hydrogels are attractive for wound applications owing to their well-defined structural, physical, and chemical properties as well as good cell adhesion and biocompatibility. This study aimed to develop gelatin hydrogels incorporated with bio-nanosilver functionalized with lactoferrin (Ag-LTF) as a dual-antimicrobial action dressing, to be used in treating infected wounds. The hydrogels were cross-linked using genipin prior to loading with Ag-LTF and characterized for their physical and swelling properties, rheology, polymer and actives interactions, and in vitro release of the actives. The hydrogel's anti-biofilm and antibacterial performances against S. aureus and P. aeruginosa as well as their cytotoxicity effects were assessed in vitro, including primary wound healing gene expression of human dermal fibroblasts (HDFs). The formulated hydrogels showed adequate release of AgNPs and LTF, with promising antimicrobial effects against both bacterial strains. The Ag-LTF-loaded hydrogel did not significantly interfere with the normal cellular functions as no alteration was detected for cell viability, migration rate, and expression of the target genes, suggesting the nontoxicity of Ag-LTF as well as the hydrogels. In conclusion, Ag-LTF-loaded genipin-cross-linked gelatin hydrogel was successfully synthesized as a new approach for fighting biofilms in infected wounds, which may be applied to accelerate healing of chronic wounds.

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Antimicrobial activity of multifaceted lactoferrin or graphene oxide functionalized silver nanocomposites biosynthesized using mushroom waste and chitosan

Abstract: Biosynthesis of multifaceted silver nanoparticles using waste mushroom and chitosan.

Cited by 38 publications

References 67 publications

The Potential of Silver Nanoparticles for Antiviral and Antibacterial Applications: A Mechanism of Action

The Potential of Silver Nanoparticles for Antiviral and Antibacterial Applications: A Mechanism of Action

Current approaches for the exploration of antimicrobial activities of nanoparticles

Gelatin Hydrogels Loaded with Lactoferrin-Functionalized Bio-Nanosilver as a Potential Antibacterial and Anti-Biofilm Dressing for Infected Wounds: Synthesis, Characterization, and Deciphering of Cytotoxicity

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