Chitosan-based nanocarriers for ophthalmic applications

Paliwal, Rishi; Paliwal, Shivani Rai; Sulakhiya, Kunjbihari; Kurmi, Balak Das; Kenwat, Rameshroo; Mamgain, Aanjaneya

doi:10.1016/b978-0-08-102553-6.00004-0

Cited by 7 publications

(6 citation statements)

References 96 publications

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“…11 Among these, chitosan (CH) is a well-known and most prominently used polymer in different ocular delivery systems. 12 It is a natural cationic polysaccharide polymer obtained from the deacetylation of chitin. 13 Moreover, CH has a strong bioadhesive property, and overcomes the rapid elimination from the ocular region by increasing the corneal contact time.…”

Section: Introductionmentioning

confidence: 99%

<p>Clarithromycin-Loaded Ocular Chitosan Nanoparticle: Formulation, Optimization, Characterization, Ocular Irritation, and Antimicrobial Activity</p>

Bin-Jumah

Gilani

Jahangir³

et al. 2020

IJN

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The topically administered drugs through conventional delivery systems have low bioavailability. Henceforth, the present study was designed to prepare and optimize clarithromycin (CTM)-loaded chitosan nanoparticles (CHNPs) to demonstrate the efficacy against microorganisms. Methods: Clarithromycin-loaded chitosan nanoparticles (CTM-CHNPs) were prepared by ionotropic gelation method. The formulation was optimized by box-Behnken design using the formulation variables like CH (A), STPP concentration (B), and stirring speed (C). Their effects were evaluated on the independent variables like particle size (Y 1) and entrapment efficiency (Y 2). Further, CTM-CHNPs were evaluated for physicochemical parameters, invitro drug release, ex-vivo permeation, bioadhesive study, corneal hydration, histopathology, HET-CAM, and antibacterial study. Results: The optimized formulation (CTM-CHNPopt) showed the low particle size (152±5 nm), which is desirable for ocular delivery. It also showed high encapsulation (70.05%), zeta potential (+35.2 mV), and was found in a spherical shape. The drug release study revealed a sustained drug release profile (82.98±3.5% in 12 hours) with Korsmeyer peppas kinetic (R 2 =0.996) release model. It showed a 2.7-fold higher corneal permeation than CTMsolution. CHNPs did not exhibit any sign of damage to excised goat cornea, which is confirmed by hydration, histopathology, and HET-CAM test. It exhibited significant (P<0.05) higher antibacterial susceptibility than CTM-solution. Conclusion: The finding of the study concluded that CTM-CHNPs can be used for effective management of bacterial conjunctivitis by increasing the precorneal residence time.

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Section: Introductionmentioning

confidence: 99%

<p>Clarithromycin-Loaded Ocular Chitosan Nanoparticle: Formulation, Optimization, Characterization, Ocular Irritation, and Antimicrobial Activity</p>

Bin-Jumah

Gilani

Jahangir³

et al. 2020

IJN

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“…Alginate can also be a useful biopolymers for designing responsive hydrogels [127]. Because of its characteristics, alginate is also used for ophthalmic applications often in combination with chitosan [128]. For example, chitosan coated sodium alginate NPs [129] loaded with Fluorouracil (5-FU) have been successfully tested for eye delivery demonstrating a high 5-FU release in aqueous humor compared to free drug in rabbit eye.…”

Section: Natural Hydrogels: Chitosan Nps (Chnps)mentioning

confidence: 99%

Noble Metals and Soft Bio-Inspired Nanoparticles in Retinal Diseases Treatment: A Perspective

Matteis

Rizzello

2020

Cells

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We are witnessing an exponential increase in the use of different nanomaterials in a plethora of biomedical fields. We are all aware of how nanoparticles (NPs) have influenced and revolutionized the way we supply drugs or how to use them as therapeutic agents thanks to their tunable physico-chemical properties. However, there is still a niche of applications where NP have not yet been widely explored. This is the field of ocular delivery and NP-based therapy, which characterizes the topic of the current review. In particular, many efforts are being made to develop nanosystems capable of reaching deeper sections of the eye such as the retina. Particular attention will be given here to noble metal (gold and silver), and to polymeric nanoparticles, systems consisting of lipid bilayers such as liposomes or vesicles based on nonionic surfactant. We will report here the most relevant literature on the use of different types of NPs for an efficient delivery of drugs and bio-macromolecules to the eyes or as active therapeutic tools.

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“…This necessitates long-term, frequent application of antiglaucoma drugs, which results in the development of local adverse effects and non-adherence, one of the leading causes of therapeutic failure. There are several successful examples of delivering anti-glaucoma drugs (e.g., timolol, cateolol, forskolin, and latanoprost) using CS alone or combined with gelatin or other compounds (Paliwal et al, 2019). A topically-applied controlled-release latanoprost thermosensitive CS-based hydrogel eye drop may provide a non-invasive alternative for the control of ocular hypertension (Cheng et al, 2014).…”

Section: Chitosan (Cs)mentioning

confidence: 99%

“…CS-based drug delivery systems have potential applications as an alternative to current injection-based therapies. For example, CS-gelatin-based solution loaded with levofloxacin or CS microspheres loaded with levofloxacin may be applied to the ocular surface at the end of ophthalmic surgery to avoid risks associated with the intraocular injection of antibiotics (Paliwal et al, 2019). Moreover, bevacizumab (anti-vascular endothelial growth factor (anti-VEGF)) therapy has demonstrated promising effects on the treatment of choroidal neovascularisation (CNV), a leading cause of blindness worldwide.…”

Section: Chitosan (Cs)mentioning

confidence: 99%

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Recent developments in regenerative ophthalmology

Shen

Guo

et al. 2020

Sci. China Life Sci.

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Regenerative medicine (RM) is one of the most promising disciplines for advancements in modern medicine, and regenerative ophthalmology (RO) is one of the most active fields of regenerative medicine. This review aims to provide an overview of regenerative ophthalmology, including the range of tools and materials being used, and to describe its application in ophthalmologic subspecialties, with the exception of surgical implantation of artificial tissues or organs (e.g., contact lens, artificial cornea, intraocular lens, artificial retina, and bionic eyes) due to space limitations. In addition, current challenges and limitations of regenerative ophthalmology are discussed and future directions are highlighted.

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Chitosan-based nanocarriers for ophthalmic applications

Cited by 7 publications

References 96 publications

<p>Clarithromycin-Loaded Ocular Chitosan Nanoparticle: Formulation, Optimization, Characterization, Ocular Irritation, and Antimicrobial Activity</p>

<p>Clarithromycin-Loaded Ocular Chitosan Nanoparticle: Formulation, Optimization, Characterization, Ocular Irritation, and Antimicrobial Activity</p>

Noble Metals and Soft Bio-Inspired Nanoparticles in Retinal Diseases Treatment: A Perspective

Recent developments in regenerative ophthalmology

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