Chitosan-based multifunctional flexible hemostatic bio-hydrogel

Song, Fuyu; Kong, Yue; Shao, Changyou; Cheng, Yi; Lü, Jie; Tao, Yehan; Du, Jian; Wang, Haisong

doi:10.1016/j.actbio.2021.09.056

Cited by 81 publications

(41 citation statements)

References 58 publications

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“…Hydrogels are hydrophilic polymers with high water content and good biocompatibility. They can be loaded with chitosan and used as wound dressings to keep the wound moist and to continuously absorb exudates ( Song et al, 2021 ). Chitosan hydrogels loaded with metal ions can improve the imbalance in metal ions that cause delayed wound healing.…”

Section: Drug Carriers Prepared Using Chitosan and Its Derivativesmentioning

confidence: 99%

Applications of Chitosan and its Derivatives in Skin and Soft Tissue Diseases

Xia

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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Chitosan and its derivatives are bioactive molecules that have recently been used in various fields, especially in the medical field. The antibacterial, antitumor, and immunomodulatory properties of chitosan have been extensively studied. Chitosan can be used as a drug-delivery carrier in the form of hydrogels, sponges, microspheres, nanoparticles, and thin films to treat diseases, especially those of the skin and soft tissue such as injuries and lesions of the skin, muscles, blood vessels, and nerves. Chitosan can prevent and also treat soft tissue diseases by exerting diverse biological effects such as antibacterial, antitumor, antioxidant, and tissue regeneration effects. Owing to its antitumor properties, chitosan can be used as a targeted therapy to treat soft tissue tumors. Moreover, owing to its antibacterial and antioxidant properties, chitosan can be used in the prevention and treatment of soft tissue infections. Chitosan can stop the bleeding of open wounds by promoting platelet agglutination. It can also promote the regeneration of soft tissues such as the skin, muscles, and nerves. Drug-delivery carriers containing chitosan can be used as wound dressings to promote wound healing. This review summarizes the structure and biological characteristics of chitosan and its derivatives. The recent breakthroughs and future trends of chitosan and its derivatives in therapeutic effects and drug delivery functions including anti-infection, promotion of wound healing, tissue regeneration and anticancer on soft tissue diseases are elaborated.

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Section: Drug Carriers Prepared Using Chitosan and Its Derivativesmentioning

confidence: 99%

Applications of Chitosan and its Derivatives in Skin and Soft Tissue Diseases

Xia

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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show abstract

“…The blood clotting capability of wound dressing is essential for the hemostatic period of wound healing [ 35 , 36 ]. Compared with severe trauma, diabetic chronic wound is associated with less bleeding, but most patients with diabetic foot need to undergo debridement surgery or even amputation surgery, so the hemostatic effect of wound dressings also plays an important role in the management of diabetic wounds after surgery.…”

Section: Resultsmentioning

confidence: 99%

Mussel-inspired collagen-hyaluronic acid composite scaffold with excellent antioxidant properties and sustained release of a growth factor for enhancing diabetic wound healing

Wang

Chen

Ren

et al. 2022

Materials Today Bio

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“…15 Chitosan usually acts as a cross-linker with aldehydes and diisocyanate functional biopolymers to prepare hydrogels. 3 Many chemical modified methods have been taken on chitosanbased hydrogels to improve their hemostasis and adhesion performance, including catechol [16][17][18][19][20][21][22][23] and pyrogallol [24][25][26] decoration, amino 27 and aldehyde 28 modification, photoactive methacrylate 17,[29][30][31][32][33] and o-nitrobenzyl 34 functionalization, etc. For example, Peng et al 35 fabricated a polyethyleneimine/polyacrylic acid/quaternized chitosan (PEI/PAA/QCS) powder through a freeze drying-grinding procedure with ultrafast self-gelling and wet adhesive properties (Fig.…”

Section: Chitosanmentioning

confidence: 99%