Chitosan based hydrogels and their applications for drug delivery in wound dressings: A review

Hamedi, Hamid; Moradi, Sara; Hudson, Samuel M.; Tonelli, Alan E.

doi:10.1016/j.carbpol.2018.06.114

Cited by 582 publications

(274 citation statements)

References 215 publications

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“…The basic requirements to generate such materials for biomedical applications include biocompatibility, biodegradability, mild processing conditions, and the ease for further modification. Chitosan is a cationic polymer of natural origin and has been extensively used as biocompatible scaffold or hydrogel for a wide range of biomedical applications, including tissue engineering [3,4], drug delivery [5][6][7][8], and many others [9][10][11][12]. Chitosan is the deacetylation product of chitin.…”

Section: Introductionmentioning

confidence: 99%

Porous chitosan by crosslinking with tricarboxylic acid and tuneable release

et al. 2020

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Chitosan hydrogels crosslinked with 1,3,5-benzene tricarboxylic acid (BTC) are readily prepared at room temperature by adding aqueous chitosan solution dropwise into BTC-ethanol solution. Highly interconnected porous chitosan materials are subsequently prepared by freeze-drying the chitosan hydrogels. These chitosan materials show porous structures with smaller pores than conventionally prepared chitosan hydrogels via crosslinking with NaOH, genipin or sodium triphosphate. This method of forming chitosan hydrogels with BTC provides the advantage of facile encapsulation of both hydrophobic and hydrophilic compounds, as demonstrated with the model dyes (Oil Red O and Rhodamine B). The release of the hydrophilic dye from the chitosan hydrogels is demonstrated and can be tuned by BTC/chitosan concentrations and the hydrogel drying methods. However, the release of encapsulated hydrophobic dye is negligible.

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Section: Introductionmentioning

confidence: 99%

Porous chitosan by crosslinking with tricarboxylic acid and tuneable release

et al. 2020

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“…Here, we aim to prepare multifunctional hydrogels able to finely tune the release of loaded bioactive species in response to specific environmental conditions and, at the same time, to act as antioxidant materials. These features greatly extend the applicability of the proposed systems in either biomedical or food packaging fields, where there is a growing interest in the development of highly engineered materials …”

Section: Introductionmentioning

confidence: 87%

Chitosan–Quercetin Bioconjugate as Multi‐Functional Component of Antioxidants and Dual‐Responsive Hydrogel Networks

Cirillo

Curcio

Spizzirri

et al. 2019

Macro Materials & Eng

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Multifunctional hydrogels based on chitosan–quercetin (CHITQ) conjugate are prepared by a thermo‐induced radical procedure in the presence of N‐isopropylacrylamide (NIPAAm), acrylamide (AAm), and N,N′‐methylenebis(acrylamide) (MEBA). At first, quercetin (Q) is grafted onto chitosan backbone with a functionalization degree of 275 mg of Q per gram of conjugate, as calculated by 1H‐NMR analyses to impart antioxidant properties to the polysaccharide. Then, a pH and temperature sensitive hydrogel was obtained by involving CHITQ and NIPAAm in the polymerization reaction. The accessibility of phenolic moieties is modified in response to the hydrogel swelling/deswelling, as confirmed by antioxidant tests performed at different temperatures. Dual stimuli‐responsive hydrogels are proposed for the delivery of caffeine as model drug. The release profiles of caffeine depict a system particularly performing as on/off device at acidic pH with excellent applicability prospects.

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“…Chain conglutinating could be accomplished by physical interactions, for instance, the secondary forces (hydrogen and ionic bonds) or thermal‐induced entanglements . Polysaccharide hydrogels can be directly prepared from solutions via hydrogen bonding and linked networks from hydroxyl groups . Some types of solvents have been exploited to dissolve native polysaccharides, such as polar solvents, ionic liquids, and alkaline/urea …”

Section: Fabrication Of Polysaccharide‐based Hydrogelsmentioning

confidence: 99%

Recent Progress of Polysaccharide‐Based Hydrogel Interfaces for Wound Healing and Tissue Engineering

Zhu

Mao

Cheng

et al. 2019

Adv Materials Inter

242

142

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Polysaccharide is an abundant and reproducible natural material that is biocompatible and biodegradable. Polysaccharide and its derivatives also possess distinctive properties such as hydrophilicity, mechanical stability, as well as tunable functionality. Polysaccharide‐based hydrogels can be constructed via the physical and/or chemical crosslinking of polysaccharide derivatives with different functional molecules, as porous network structures or nanofibrillar structures. This review discusses the biomedical applications of polysaccharide‐based hydrogels containing native polysaccharides, polysaccharide derivatives, and polysaccharide‐composite hydrogels. Recent works on the fabrication, physical properties, advanced engineering, biomedical applications of cellulose‐, chitosan‐, alginate‐, and starch‐based hydrogels are also elaborated. Such porous swelling scaffolds exhibit great advantages at the interface of a negative pressure system such as wound dressing. In addition, the authors also discuss and summarize the exemplary research works of these hydrogels in the applications of drug release, wound dressing, and tissue engineering. Finally, challenges and future perspectives about the development of polysaccharide‐based hydrogels are discussed.

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Chitosan based hydrogels and their applications for drug delivery in wound dressings: A review

Cited by 582 publications

References 215 publications

Porous chitosan by crosslinking with tricarboxylic acid and tuneable release

Porous chitosan by crosslinking with tricarboxylic acid and tuneable release

Chitosan–Quercetin Bioconjugate as Multi‐Functional Component of Antioxidants and Dual‐Responsive Hydrogel Networks

Recent Progress of Polysaccharide‐Based Hydrogel Interfaces for Wound Healing and Tissue Engineering

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