Porous chitosan by crosslinking with tricarboxylic acid and tuneable release

Yang, Yonghong; Chen, Guanhong; Murray, Patricia; Zhang, Haifei

doi:10.1007/s42452-020-2252-z

Cited by 28 publications

(26 citation statements)

References 39 publications

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“…The morphological characteristics of the KT-CTS gel showed that it has a compact and dense structure. This was also observed by Yanget al [29]. Nevertheless, other researchers observed la-…”

Section: Discussionsupporting

confidence: 76%

Polymeric Nanoparticles and Chitosan Gel Loading Ketorolac Tromethamine to Alleviate Pain Associated with Condyloma Acuminata during the Pre- and Post-Ablation

et al. 2021

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This study describes the preparation and evaluation of two formulations, a hydrogel and a nanostructured system, containing ketorolac tromethamine as an anti-inflammatory agent for the local therapy against the inflammatory process derived from the surgical excision of Condyloma acuminata. Both formulations were physicochemically characterized.In vitrorelease profiles show that the nanoparticles release 92%±2.3 of the total ketorolac tromethamine encapsulated, while the chitosan gel releases 18.6%±0.2. Theex vivo permeation and distribution through human skin were also assayed and was observed how the main amount of ketorolac tromethamine is retained in the epidermis. In vivo studies were accomplished to evaluate the anti-inflammatory efficacy in mice which also involved the histological analysis to confirm thein vivoresults. The nanoparticles present a significantly higher anti-inflammatory efficacy than chitosan gel. The tolerability of developedformulations was assessed by monitoring the biomechanical properties of the skin before and after application of both formulations. No statistical differences in trans-epidermal water loss and skin hydration with respect to the basal values were observed and the formulations exhibited higher anti-inflammatory activity compared to a reference ketotorlac tromethamine solution. Therefore, it can be concluded that both formulations can be proposed as outstanding candidates for offering a local anti-inflammatory therapeutical toolwith potential clinical application.

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Section: Discussionsupporting

confidence: 76%

Polymeric Nanoparticles and Chitosan Gel Loading Ketorolac Tromethamine to Alleviate Pain Associated with Condyloma Acuminata during the Pre- and Post-Ablation

et al. 2021

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“…LS is quickly released from the NPs in the initial 10 h [ 125 ] Ionic gelation method CS porous NPs Oil Red O and Rhodamine B. Denser hydrogels and Highly interconnected macropores, around 50–200 nm and relatively uniformly around 50–100 nm, SF methods A fast release for 1 h, then reaching the equilibrium concentration [ 126 ] Ionic interaction with dextran sulfate (DS) as a crosslinker CS NPs Double-stranded siRNA Irregular morphology, d = 353–1083 nm. SS methods DS and CS concentration influenced the size of NPs.…”

Section: Drug Release From Csnpsmentioning

confidence: 99%

“…The swelling of CSNPs, at a higher pH value (7.4) may increase, which would allow release media to penetrate deeper into the polymer matrix, converting the glassy polymer to a rubbery state [ 134 ]. Drug molecules were able to diffuse out of the CSNPs more quickly and release quickly [ 126 ].…”

Section: Drug Release From Csnpsmentioning

confidence: 99%

Drug release study of the chitosan-based nanoparticles

Herdiana

Wathoni

Shamsuddin

et al. 2022

Heliyon

201

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Recently, multifunctional drug delivery systems (DDSs) have been designed to provide a comprehensive approach with multiple functionalities, including diagnostic imaging, targeted drug delivery, and controlled drug release. Chitosan-based drug nanoparticles (CSNPs) systems are employed as diagnostic imaging and delivering the drug to particular targeted sites in a regulated manner. Drug release is an important factor in ensuring high reproducibility, stability, quality control of CSNPs, and scientific-based for developing CSNPs. Several factors influence drug release from CSNPs, including composition, composition ratio, ingredient interactions, and preparation methods. Early, CSNPs were used for improving drug solubility, stability, pharmacokinetics, and pharmacotherapeutics properties. Chitosan has been developed toward a multifunctional drug delivery system by exploring positively charged properties and modifiable functional groups. Various modifications to the polymer backbone, charge, or functional groups will undoubtedly affect the drug release from CSNPs. The drug release from CSNPs has a significant influence on its therapeutic actions. Our review's objective was to summarize and discuss the relationship between the modification in CSNPs as multifunctional delivery systems and drug release properties and kinetics of the drug release model. Kinetic models help describe the release rate, leading to increased efficiency, accuracy, the safety of the dose, optimizing the drug delivery device's design, evaluating the drug release rate, and improvement of patient compatibility. In conclusion, almost all CSNPs showed bi-phasic release, initial burst release drug in a particular time followed controlled manner release in achieving the expected release, stimuli external can be applied. CSNPs are a promising technique for multifunctional drug delivery systems.

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“…A physical process occurs when experimental parameters such as pH or temperature are varied, or through the addition of counterions, while a chemical process takes place through the addition of chemical crosslinkers such as glutaraldehyde or diisocyanate [70]. The addition of such chemical agents modifies the chemical properties of pure chitosan-based hydrogels but can give rise to some toxicological concerns; in this regard, the use of biocompatible agents such as genipin may be a suitable approach [136,137].…”

Section: Chitosan-based Hydrogelsmentioning

confidence: 99%

Recent Advances of Taxol-Loaded Biocompatible Nanocarriers Embedded in Natural Polymer-Based Hydrogels

Voci

Gagliardi

Molinaro

et al. 2021

Gels

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The discovery of paclitaxel (PTX) has been a milestone in anti-cancer therapy and has promoted the development and marketing of various formulations that have revolutionized the therapeutic approach towards several malignancies. Despite its peculiar anti-cancer activity, the physico-chemical properties of PTX compromise the administration of the compound in polar media. Because of this, since the development of the first Food and Drug Administration (FDA)-approved formulation (Taxol®), consistent efforts have been made to obtain suitable delivery systems able to preserve/increase PTX efficacy and to overcome the side effects correlated to the presence of some excipients. The exploitation of natural polymers as potential materials for drug delivery purposes has favored the modulation of the bioavailability and the pharmacokinetic profiles of the drug, and in this regard, several formulations have been developed that allow the controlled release of the active compound. In this mini-review, the recent advances concerning the design and applications of natural polymer-based hydrogels containing PTX-loaded biocompatible nanocarriers are discussed. The technological features of these formulations as well as the therapeutic outcome achieved following their administration will be described, demonstrating their potential role as innovative systems to be used in anti-tumor therapy.

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Porous chitosan by crosslinking with tricarboxylic acid and tuneable release

Cited by 28 publications

References 39 publications

Polymeric Nanoparticles and Chitosan Gel Loading Ketorolac Tromethamine to Alleviate Pain Associated with Condyloma Acuminata during the Pre- and Post-Ablation

Polymeric Nanoparticles and Chitosan Gel Loading Ketorolac Tromethamine to Alleviate Pain Associated with Condyloma Acuminata during the Pre- and Post-Ablation

Drug release study of the chitosan-based nanoparticles

Recent Advances of Taxol-Loaded Biocompatible Nanocarriers Embedded in Natural Polymer-Based Hydrogels

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