Chitosan-based dressings loaded with neurotensin—an efficient strategy to improve early diabetic wound healing

Moura, Liane I.F.; Dias, Ana M.A.; Leal, Ermelindo C.; Carvalho, Lina; Sousa, Hermínio C. de; Carvalho, Eugénia

doi:10.1016/j.actbio.2013.09.040

Cited by 131 publications

(86 citation statements)

References 47 publications

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, we show that the alginate gels provide sustained release of SP and NT, which have been previously validated for DM wound healing in our mouse model. 10,11 We also show that peri-wound injection of the alginate gels incorporating SP and NT accelerates healing. Finally, we demonstrate safety and biocompatibility of DNA-based gels in vivo.…”

Section: Discussionmentioning

confidence: 95%

“…We used injectable alginate gels to release a combination of SP and NT, as these neuropeptides have shown to improve DM-impaired healing when individually applied to the wounds. 10,11 We also used macroporous alginate polymer scaffolds to encapsulate and deliver OEC to the wounds, either in single therapy or in combination with SP. Finally, we applied a new DNA nanoparticle system to non-DM and DM mouse wounds to evaluate its potential adverse or beneficial effects in wound healing.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Alginate and DNA Gels Are Suitable Delivery Systems for Diabetic Wound Healing

Tellechea

Silva

Min

et al. 2015

The International Journal of Lower Extremity Wounds

Self Cite

View full text Add to dashboard Cite

Diabetic foot ulcers (DFU) represent a severe health problem and an unmet clinical challenge. In this study, we tested the efficacy of novel biomaterials in improving wound healing in mouse models of diabetes mellitus (DM). The biomaterials are composed of alginate-and deoxyribonucleic acid (DNA)-based gels that allow incorporation of effector cells, such as outgrowth endothelial cells (OEC), and provide sustained release of bioactive factors, such as neuropeptides and growth factors, which have been previously validated in experimental models of DM wound healing or hind limb ischemia. We tested these biomaterials in mice and demonstrate that they are biocompatible and can be injected into the wound margins without major adverse effects. In addition, we show that the combination of OEC and the neuropeptide Substance P has a better healing outcome than the delivery of OEC alone, while subtherapeutic doses of vascular endothelial growth factor (VEGF) are required for the transplanted cells to exert their beneficial effects in wound healing. In summary, alginate and DNA scaffolds could serve as potential delivery systems for the next-generation DFU therapies.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Alginate and DNA Gels Are Suitable Delivery Systems for Diabetic Wound Healing

Tellechea

Silva

Min

et al. 2015

The International Journal of Lower Extremity Wounds

Self Cite

View full text Add to dashboard Cite

show abstract

“…Other chitosan derivatives developed for other purposes have also been described in literature in the context of wound healing (Alves & Mano, 2008;Casettari et al, 2012;Francesko & Tzanov, 2011;Park et al, 2010). Specifically, for diabetic wounds, where healing fails, other chitosan derivatives have been proposed (Moura et al 2013) to increase fibroblast migration and collagen deposition in diabetic mice (Moura et al 2014). …”

Section: Figure 1 Wound Classification (Kyriacos Et Al 2008)mentioning

confidence: 99%

Chitosan as a starting material for wound healing applications

Patrulea

Ostafe

Borchard

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

441

215

View full text Add to dashboard Cite

Abstract:Chitosan and its derivatives have attracted great attention due to their properties beneficial for application to wound healing. The main focus of the present review is to summarize studies involving chitosan and its derivatives, especially N,N,N-trimethylchitosan (TMC), N,O-carboxymethyl-chitosan (CMC) and O-carboxymethyl-N,N,Ntrimethyl-chitosan (CMTMC), used to accelerate wound healing. Moreover, formulation strategies for chitosan and its derivatives, as well as their in vitro, in vivo and clinical applications in wound healing are described.

show abstract

“…Apart from the above systems, other drugs delivered to wound sites using polysaccharide polymers include antioxidants [254], debriding agents [255] and peptides [256,257]. However, a detailed and extensive evaluation is not provided here as this falls outside the scope of the current review and the reader is encouraged to consult more specific literature on these.…”

Section: Polysaccharide-based Wound Delivery Systemsmentioning

confidence: 99%

Polysaccharide Based Formulations for Mucosal Drug Delivery: A Review

Boateng

Okeke²,

Khan³

2015

CPD

View full text Add to dashboard Cite

There has been increased interest in novel drug delivery systems to be administered via mucosal routes as an alternative to the currently used traditional routes such as parenteral (injections) and oral routes of administration. This is due to the several advantages they offer including avoiding first pass metabolism in the liver for oral administration and local activity which avoids the need for high systemic doses. To achieve the foregoing objectives, bioadhesive vehicles are required that ensure prolonged residence time to achieve systemic bioavailability via substantial drug absorption or significant drug concentration for local action.The drug delivery system is also required to be non-deleterious to the site of application and be well tolerated by vulnerable groups such as paediatric and geriatric patients. These essential characteristics are mainly satisfied by naturally occurring polymers, including polysaccharide based polymers which have the advantage of biocompatibility, biodegradability and therefore safety. This review discusses various bioadhesive polymers of polysaccharide origin formulated into a variety of dosage forms for drug delivery via the body's mucosal (moist) surfaces including ocular, oral (buccal and sublingual), nasal, gastrointestinal and vaginal mucosa, as well as moist wound sites. The anatomy and / or physiology of each site, coupled with the unique challenges each poses, the strategies employed for ensuring therapeutic efficacy, as well as the current state of the art will also be covered.

show abstract

Chitosan-based dressings loaded with neurotensin—an efficient strategy to improve early diabetic wound healing

Cited by 131 publications

References 47 publications

Alginate and DNA Gels Are Suitable Delivery Systems for Diabetic Wound Healing

Alginate and DNA Gels Are Suitable Delivery Systems for Diabetic Wound Healing

Chitosan as a starting material for wound healing applications

Polysaccharide Based Formulations for Mucosal Drug Delivery: A Review

Contact Info

Product

Resources

About