Alginate and DNA Gels Are Suitable Delivery Systems for Diabetic Wound Healing

Tellechea, Ana; Silva, Eduardo A.; Min, Jianghong; Leal, Ermelindo C.; Auster, Michael E.; Pradhan-Nabzdyk, Leena; Shih, William M.; Mooney, David J.; Veves, Aristidis

doi:10.1177/1534734615580018

Cited by 30 publications

(21 citation statements)

References 28 publications

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“…Adaptation of these materials for transdermal drug delivery is highly appealing, and these hydrogels have been used to deliver proteins such as insulin and calcitonin 7 . Alginate hydrogels, similar to those in use for decades to treat wounds 24 , have been shown to controllably deliver potential therapeutics like substance P to promote wound healing 25 . Some of these materials are currently being evaluated in clinical trials.…”

Section: Macroscopic Design and Delivery Routesmentioning

confidence: 99%

Designing hydrogels for controlled drug delivery

2016

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Hydrogel delivery systems can leverage therapeutically beneficial outcomes of drug delivery and have found clinical use. Hydrogels can provide spatial and temporal control over the release of various therapeutic agents, including small-molecule drugs, macromolecular drugs and cells. Owing to their tunable physical properties, controllable degradability and capability to protect labile drugs from degradation, hydrogels serve as a platform in which various physiochemical interactions with the encapsulated drugs control their release. In this Review, we cover multiscale mechanisms underlying the design of hydrogel drug delivery systems, focusing on physical and chemical properties of the hydrogel network and the hydrogel–drug interactions across the network, mesh, and molecular (or atomistic) scales. We discuss how different mechanisms interact and can be integrated to exert fine control in time and space over the drug presentation. We also collect experimental release data from the literature, review clinical translation to date of these systems, and present quantitative comparisons between different systems to provide guidelines for the rational design of hydrogel delivery systems.

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Section: Macroscopic Design and Delivery Routesmentioning

confidence: 99%

Designing hydrogels for controlled drug delivery

2016

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“…One unique property of alginate is the ability to be physically crosslinked by divalent cations such as Ca 2+ at room temperature [11, 37, 38, 74–76], which makes it very useful in various biofabrication techniques, including molding, spraying, and 3D bioprinting [77–80]. The resulting physical hydrogels have good biocompatibility, low toxicity, and relatively low cost [36–39, 81–89]. Alginate hydrogels have been shown to support growth and proliferation of encapsulated chondrocytes, as well as to maintain their chondrogenic phonotype.…”

Section: Designing Hydrogels For Reconstruction Of Osteochondral Imentioning

confidence: 99%

Cell-laden hydrogels for osteochondral and cartilage tissue engineering

et al. 2017

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Despite tremendous advances in the field of regenerative medicine, it still remains challenging to repair the osteochondral interface and full-thickness articular cartilage defects. This inefficiency largely originates from the lack of appropriate tissue engineered artificial matrices that can replace the damaged regions and promote tissue regeneration. Hydrogels are emerging as a promising class of biomaterials for both soft and hard tissue regeneration. Many critical properties of hydrogels, such as mechanical stiffness, elasticity, water content, bioactivity, and degradation, can be rationally designed and conveniently tuned by proper selection of the material and chemistry. Particularly, advances in the development of cell-laden hydrogels have opened up new possibilities for cell therapy. In this article, we describe the problems encountered in this field and review recent progress in designing cell-hydrogel hybrid constructs for promoting the reestablishment of osteochondral/cartilage tissues. Our focus centers on the effects of hydrogel type, cell type, and growth factor delivery on achieving efficient chondrogenesis and osteogenesis. We give our perspective on developing next-generation matrices with improved physical and biological properties for osteochondral/cartilage tissue engineering. We also highlight recent advances in biomanufacturing technologies (e.g. molding, bioprinting, and assembly) for fabrication of hydrogel-based osteochondral and cartilage constructs with complex compositions and microarchitectures to mimic their native counterparts.

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“…The release of cells can be easily triggered by using nucleases to degrade this Dgel to nontoxic nucleotides as by‐products. The biomaterials composed of Dgels coincorporated with endothelial cells (OEC), neuropeptides, and growth factors can be injected into the diabetic wound margins for better healing outcome without obvious adverse effect comparing to the delivery of OEC alone …”

Section: Biomedical Applicationsmentioning

confidence: 99%

Programmable and Multifunctional DNA‐Based Materials for Biomedical Applications

et al. 2018

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DNA encodes the genetic information; recently, it has also become a key player in material science. Given the specific Watson-Crick base-pairing interactions between only four types of nucleotides, well-designed DNA self-assembly can be programmable and predictable. Stem-loops, sticky ends, Holliday junctions, DNA tiles, and lattices are typical motifs for forming DNA-based structures. The oligonucleotides experience thermal annealing in a near-neutral buffer containing a divalent cation (usually Mg ) to produce a variety of DNA nanostructures. These structures not only show beautiful landscape, but can also be endowed with multifaceted functionalities. This Review begins with the fundamental characterization and evolutionary trajectory of DNA-based artificial structures, but concentrates on their biomedical applications. The coverage spans from controlled drug delivery to high therapeutic profile and accurate diagnosis. A variety of DNA-based materials, including aptamers, hydrogels, origamis, and tetrahedrons, are widely utilized in different biomedical fields. In addition, to achieve better performance and functionality, material hybridization is widely witnessed, and DNA nanostructure modification is also discussed. Although there are impressive advances and high expectations, the development of DNA-based structures/technologies is still hindered by several commonly recognized challenges, such as nuclease instability, lack of pharmacokinetics data, and relatively high synthesis cost.

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Alginate and DNA Gels Are Suitable Delivery Systems for Diabetic Wound Healing

Cited by 30 publications

References 28 publications

Designing hydrogels for controlled drug delivery

Designing hydrogels for controlled drug delivery

Cell-laden hydrogels for osteochondral and cartilage tissue engineering

Programmable and Multifunctional DNA‐Based Materials for Biomedical Applications

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