Chitosan-based core–shell structured particles for in vivo sustainable gene transfection

Lin, Fu-xing; Rong, Jie-lin; Wang, Mozhen; Bao, Dandan; Wang, Yun; Gong, Zhen-xing; Gu, Yufang; Yu, Zhiwen; Xia, Ge

doi:10.1039/c5tb02074c

Cited by 9 publications

(1 citation statement)

References 45 publications

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“…For the analysis of the amount of immobilized −SH groups of these thiolated chitosans, Ellman’s reagent optionally with previous reduction of disulfide bonds with borohydride or iodometric titration can be used . Phadungcharoen et al, for instance, have conducted the Ellman’s assay via smartphone, providing an easy, fast, and reliable analysis of thiolated polymers without access to sophisticated equipment. …”

Section: Chitosan: Its Chemistry and Thiolationmentioning

confidence: 99%

Thiolated Chitosans: A Multi-talented Class of Polymers for Various Applications

2020

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Various properties of chitosan can be customized by thiolation for very specific needs in a wide range of application areas. Since the discovery of thiolated chitosans, many studies have proven their advantageous characteristics, such as adhesion to biological surfaces, adjustable cross-linking and swelling behavior, controllable drug release, permeation as well as cellular uptake enhancement, inhibition of efflux pumps and enzymes, complexation of metal ions, antioxidative properties, and radical scavenging activity. Simultaneously, these polymers remain biodegradable without increased toxicity. Within this Review, an overview about the different possibilities to covalently attach sulfhydryl ligands to the polymeric backbone of chitosan is given, and the resulting versatile physiochemical properties are discussed in detail. Furthermore, the broad spectrum of applications for thiolated chitosans in science and industry, ranging from their most advanced use in pharmaceutical and medical science over wastewater treatment to the impregnation of textiles, is addressed.

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Section: Chitosan: Its Chemistry and Thiolationmentioning

confidence: 99%

Thiolated Chitosans: A Multi-talented Class of Polymers for Various Applications

2020

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An RGD-modified hollow silica@Au core/shell nanoplatform for tumor combination therapy

Xing

et al. 2017

Acta Biomaterialia

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Thermo-responsive behaviors and bioactivities of hydroxybutyl chitosans prepared in alkali/urea aqueous solutions

Cai

Cao

et al. 2019

Carbohydrate Polymers

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Chitosan-based core–shell structured particles for in vivo sustainable gene transfection

Abstract: pEGFP-loaded thiolated and N-alkylated chitosan particles coated by a PEGylated hydroxybutyl chitosan shell show a good sustainable gene transfection effect.

Cited by 9 publications

References 45 publications

Thiolated Chitosans: A Multi-talented Class of Polymers for Various Applications

Thiolated Chitosans: A Multi-talented Class of Polymers for Various Applications

An RGD-modified hollow silica@Au core/shell nanoplatform for tumor combination therapy

Thermo-responsive behaviors and bioactivities of hydroxybutyl chitosans prepared in alkali/urea aqueous solutions

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