Chitosan attenuates dibutyltin-induced apoptosis in PC12 cells through inhibition of the mitochondria-dependent pathway

An Overview of the Protective Effects of Chitosan and Acetylated Chitosan Oligosaccharides against Neuronal Disorders

“…Thus, tackling mitochondrial dysfunction offers a promising therapeutic target in neurodegenerative disease. Wang et al discovered that chitosan (CS) could significantly increase the cell viability and decrease the lactate dehydrogenase (LDH) release induced by Dibutyltin (DBT) in a dose-dependent manner [63]. CS could inhibit cell apoptosis, mitochondrial membrane potential (MMP) disruption, and ROS generation in PC12 cells [63].…”

“…Wang et al discovered that chitosan (CS) could significantly increase the cell viability and decrease the lactate dehydrogenase (LDH) release induced by Dibutyltin (DBT) in a dose-dependent manner [63]. CS could inhibit cell apoptosis, mitochondrial membrane potential (MMP) disruption, and ROS generation in PC12 cells [63]. Therefore, CS may inhibit DBT-induced apoptosis in PC12 cells through interfering with the mitochondria-dependent pathway [63].…”

“…CS could inhibit cell apoptosis, mitochondrial membrane potential (MMP) disruption, and ROS generation in PC12 cells [63]. Therefore, CS may inhibit DBT-induced apoptosis in PC12 cells through interfering with the mitochondria-dependent pathway [63]. …”

“…Wang et al found that pretreatment with chitosan (CS) significantly increased the cell viability and decreased LDH release induced by DBT in a dose-dependent manner [63]. Meanwhile, DBT-induced cell apoptosis, the disruption of mitochondrial membrane potential (MMP), and the generation of intracellular ROS were attenuated by CS [63].…”

“…Meanwhile, DBT-induced cell apoptosis, the disruption of mitochondrial membrane potential (MMP), and the generation of intracellular ROS were attenuated by CS [63]. CS also inhibited the DBT-inducted activation of caspase-9 and -3 at mRNA and protein expression levels.…”