Chitosan as capping agent in a robust one-pot procedure for a magnetic catalyst synthesis

Dickstein, Tomer A.; Zhou, Ergang; Hershberger, Kian K.; Haskell, Angela K.; Morgan, David; Pink, Maren; Stein, Barry D.; Nikoshvili, Linda Zh.; Matveeva, Valentina G.; Bronstein, Lyudmila M.

doi:10.1016/j.carbpol.2021.118267

Cited by 5 publications

(2 citation statements)

References 78 publications

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“…Deconvolution of high-resolution C 1s core-level spectra of the resulting HTCC/amylose/AuNPs was used to obtain quantitative results for the functional group . However, it is not easy to determine the nature of the incorporated groups as the contribution from C–O and C–N groups can be overlapped. , Typical deconvoluted-C 1s core-level spectra of the amylose/AuNPs and HTCC/amylose/AuNPs are shown in Figure C,D, and the contribution of elemental carbon from different chemical functionalities after deconvolution are listed in Table .…”

Section: Resultsmentioning

confidence: 99%

Positively Charged-Amylose-Entangled Au-Nanoparticles Acting as Protein Carriers and Potential Adjuvants to SARS-CoV-2 Subunit Vaccines

Fan

et al. 2023

ACS Appl. Mater. Interfaces

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The COVID-19 pandemic continues to spread worldwide. To protect and control the spread of SARS-CoV-2, varieties of subunit vaccines based on spike (S) proteins have been approved for human applications. Here, we report a new subunit vaccine design strategy that functions as both an antigen carrier and an adjuvant in immunization to elicit high-level immune responses. The complex of 2-hydroxypropyl-trimethylammonium chloride chitosan and amylose entangles Au nanoparticles (HTCC/amylose/AuNPs) forming 40 nm nanocarriers with a positive charge. The obtained positively charged nanoparticles reveal many merits, including the larger S protein loading capacity in PBS buffer, higher cellular uptake ability, and lower cell cytotoxicity, supporting their potential as safe vaccine nanocarriers. Two functionalized nanoparticle subunit vaccines are prepared via loading full-length S proteins derived from SARS-CoV-2 variants. In mice, both prepared vaccines elicit high specific IgG antibodies, neutralize antibodies, and immunoglobulin IgG1 and IgG2a. The prepared vaccines also elicit robust T- and B-cell immune responses and increase CD19+ B cells, CD11C+ dendritic cells, and CD11B+ macrophages at the alveoli and bronchi of the immunized mice. Furthermore, the results of skin safety tests and histological observation of organs indicated in vivo safety of HTCC/amylose/AuNP-based vaccines. Summarily, our prepared HTCC/amylose/AuNP have significant potential as general vaccine carriers for the delivery of different antigens with potent immune stimulation.

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Section: Resultsmentioning

confidence: 99%

Positively Charged-Amylose-Entangled Au-Nanoparticles Acting as Protein Carriers and Potential Adjuvants to SARS-CoV-2 Subunit Vaccines

Fan

et al. 2023

ACS Appl. Mater. Interfaces

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“…Therefore, it is reasonable that the peak at 401.7 eV was attributed to -N(CH 3 ) 3 + , while the peaks at 396.6 and 399.5 eV were assigned to the intact and interacted nitrogen-containing functional groups of chitosan, respectively. 36,37 The slight change in the binding energies for the nitrogen-containing functional groups of chitosan by the modification with GTMAC was probably due to the presence of GTMAC. Based on these results and discussion, it can be concluded that GTMAC was successfully introduced in MM/ Chi/GTMAC, which is then tested as a solid base-catalyst for esterification of LA to LE.…”

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confidence: 99%

Modification of chitosan-coated magnetic material with glycidyltrimethylammonium chloride and its application as heterogeneous base catalyst for levulinic acid esterification

Mukhayani,

Kamiya,

Otomo

et al. 2024

Mater. Adv.

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Chitosan coated selenium: A versatile nano-delivery system for molecular cargoes

Davidson,

Pereira,

Leon

et al. 2024

International Journal of Biological Macromolecules

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Chitosan as capping agent in a robust one-pot procedure for a magnetic catalyst synthesis

Cited by 5 publications

References 78 publications

Positively Charged-Amylose-Entangled Au-Nanoparticles Acting as Protein Carriers and Potential Adjuvants to SARS-CoV-2 Subunit Vaccines

Positively Charged-Amylose-Entangled Au-Nanoparticles Acting as Protein Carriers and Potential Adjuvants to SARS-CoV-2 Subunit Vaccines

Modification of chitosan-coated magnetic material with glycidyltrimethylammonium chloride and its application as heterogeneous base catalyst for levulinic acid esterification

Chitosan coated selenium: A versatile nano-delivery system for molecular cargoes

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