Chitosan and O-carboxymethyl chitosan modified Fe₃O₄ for hyperthermic treatment

Abstract

In this study magnetic fluids were manufactured by the adsorption of chitosan (CS) and O-carboxymethyl chitosan (OCMCS) on Fe 3 O 4 nanoparticles to be used as hyperthermic thermoseeds. Fe 3 O 4 particles were characterized by physico-chemical methods such as: thermogravimetry analysis (TGA), x-ray diffraction (XRD), Raman spectrum, Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM) and vibrating sample magnetometer (VSM). The SEM images and XRD patterns showed that the synthesized Fe 3 O 4 nanoparticles were of single phase and spherical shape with 10–15 nm in diameter. The VSM measurements showed that Fe 3 O 4 particles were superparamagnetic with saturation magnetization of 70 emu g −1. The adsorbed layers of CS and OCMCS on the magnetite surface (Fe 3 O 4/CS) and (Fe 3 O 4/OCMCS) were confirmed by FTIR, Raman spectra and SEM. In the ac magnetic field of 80 Oe and 236 kHz, the saturation heating temperatures of the sample Fe 3 O 4/CS and Fe 3 O 4/OCMCS were 100 and 98 °C, respectively. At the same concentration of Fe 3 O 4 nanoparticles in suspension, the two magnetic fluids exhibited quite high heating capacity, with different behaviors of concentration dependence. The Fe 3 O 4/CS and Fe 3 O 4/OCMCS nanoparticles would serve as good thermoseeds for localized hyperthermia treatment of cancers.

Mechanical and biological properties of chitosan/carbon nanotube nanocomposite films

“…Another typical intense band was due to υ(CO) stretching at 1355 cm −1 . Finally, a peak at 2850 cm −1 corresponded to a CCH 3 band . Furthermore, MWCNT powder Raman spectra revealed a number of main peaks.…”

“…Finally, a peak at 2850 cm 21 corresponded to a CACH 3 band. 47,48 Furthermore, MWCNT powder Raman spectra revealed a number of main peaks. A low energy mode observed at Raman shift between 100 and 200 cm 21 is considered a "radial breathing modes" (RBM) where all atoms vibrate radially in phase.…”

Synthesis, inductive heating, and magnetoimpedance-based detection of multifunctional Fe3O4 nanoconjugates

“…Magnetite nanoparticles were synthesized by co-precipitation of ferric and ferrous hydroxide in alkaline conditions as described in Mai et al [23]. All of the raw materials used in the synthesis process were purchased commercially from Merck and used without further M a n u s c r i p t 4 purification.…”

Biomedical applications of carboxymethyl chitosans

“…Also the experimental data suggested that due to the folate-receptor-mediated endocytosis, cellular uptake of folate-modified CM-chitosan nanoparticles was found to be higher than that of nanoparticles based on linoleic acid modified CM-chitosan thereby providing higher cytotoxicity against HeLa cells (Tan & Liu, 2011). The potential of Fe 3 O 4 /chitosan and Fe 3 O 4 /OCM-chitosan nanoparticles as good thermo seeds for localized hyperthermia treatment of cancer has been currently demonstrated (Mai et al, 2012).…”