Chitosan and Chitosan Derivatives in Drug Delivery and Tissue Engineering

Riva, Raphaël; Ragelle, Héloïse; Rieux, Anne des; Duhem, Nicolas; Jérôme, Christine; Préat, Véronique

doi:10.1007/12_2011_137

Cited by 297 publications

(187 citation statements)

References 146 publications

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“…Chitosan chains possess three attractive reactive sites for chemical modification: two hydroxyl groups (primary or secondary) and one primary amine. The site of modification is dictated by the desired application of the final chitosan derivative [1].…”

Section: Abstract-anti-biotics Tetracycline Hydrochloride Expired Dmentioning

confidence: 99%

Natural Bio-Polymer and Pharmaceutical Drugs in Textile Processing

2017

IJACEBS

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Section: Abstract-anti-biotics Tetracycline Hydrochloride Expired Dmentioning

confidence: 99%

Natural Bio-Polymer and Pharmaceutical Drugs in Textile Processing

2017

IJACEBS

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“…Adanya polimer juga dapat mencegah oksidasi besi oksida. Polimer alam seperti kitosan sangat direkomendasikan dalam sistem pembawa obat, karena sifat kitosan yang biokompatibel dan biodegradabel [6].…”

Section: Pendahuluanunclassified

“…Namun, jika berat molekulnya terlalu besar diperlukan enzim chitinase yang mampu mengubah kitosan dengan berat molekul yang besar menjadi rantai yang lebih pendek. Laju degradasi kitosan tergantung dari berat molekul dan derajat asetilasi dari kitosan [6]. Kitosan dapat diikatkan silang (crosslinked) secara kimia maupun secara fisika karena adanya gugus fungsi amino dan hidroksil pada strukturnya untuk pelepasan obat yang terkontrol [7], dan peningkatkan kestabilan kitosan [5].…”

Section: Pendahuluanunclassified

Preparation of Chitosan-Fe3O4 Nanoparticles by In-situ Co-Precipitation Using Tripolyphosphate / Citrate as Crosslinker and Characterization Using XRD

Mardila

Sabarudin

Santjojo

2016

Nat-B

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ABSTRAKNanopartikel kitosan-Fe3O4 telah disintesis secara one pot reaction dengan menggunakan kombinasi TPP:sitrat sebagai crosslinker. Metode yang digunakan yaitu ko-presipitasi in-situ garam besi dengan adanya kitosan dan crosslinker. Penelitian ini bertujuan untuk mengetahui pengaruh proses preparasi terhadap karakteristik nanopartikel kitosan-Fe3O4 yang dibuat pada beberapa kondisi yaitu rasio kitosan:Fe(II):Fe(III), rasio TPP:sitrat dan waktu crosslinking. Ukuran kristal nanopartikel hasil sintesis dihitung dengan menggunakan persamaan Debye Scherrer termodifikasi dengan nilai panjang gelombang, intensitas, 2θ, dan FWHM yang dihasilkan dari uji XRD. Ukuran kristal bare Fe3O4 dan nanopartikel kitosan-Fe3O4 masing-masing yaitu 6,22 nm dan 9,49 nm. Hasil analisis XRD menunjukkan bahwa pada nanopartikel hasil sintesis selain fasa Fe3O4 terdapat pula fasa γ-Fe2O3 yang diduga karena oksidasi Fe3O4. Ukuran kristal dan presentase Fe3O4 menurun dengan semakin banyaknya jumlah kitosan yang melapisi Fe3O4 dan semakin lamanya waktu crosslinking.Kata kunci: magnetik nanopartikel, kitosan-Fe3O4, in-situ, ko-presipitasi.

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“…Natural biopolymers such as chitosan or alginate and their derivatives have attracted considerable interest in a wide range of biomedical and pharmaceutical applications including drug delivery and tissue engineering [12][13][14][15] . Several advantages including healing properties, biocompatibility, availability, biodegradability and non-toxicity [16][17][18] made them suitable for pharmaceutical preparations.…”

mentioning

confidence: 99%

Preparation and Characterization of Cross-Linked Chitosan Microcapsules for Controlled Delivery of Oxytetracycline

Larbi-Bouamrane¹,

Bal²,

Aliouche³

et al. 2016

pharmaceutical-sciences

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Larbi-Bouamrane, et al.: Preparation of Chitosan Microcapsules for Delivery of OxytetracyclineFormulations of encapsulated oxytetracycline in chitosan spherical beads have been developed in this work through the ionotropic gelation method in sodium tripolyphosphate or hexametaphosphate and characterized as drug delivery system to the gastrointestinal tract by Fourier transform infrared spectroscopy, thermal analysis and in vitro drug release in simulated gastric fluids. The Fourier transform infrared spectroscopy and differential scanning calorimetry measurements showed that tripolyphosphate and hexametaphosphate are cross-linked ionically to chitosan and there was no significant drug interaction between the entrapped drug and the carrying polymer. With respect to chitosan cross-linking features, sodium hexametaphosphate seems to give better swelling, higher diffusion and faster release kinetics, while addition of glutaraldehyde as a second cross-linking agent lowers the drug discharge. Release extent and kinetics were found to be pH dependent and approximated very well by the multistep models equations of Makoid-Banakar, PeppasSahlin and Korsmeyer-Peppas. Key words: Oxyteracycline, chitosan, encapsulation, crosslinking, release kineticsTetracyclines are broad spectrum antibiotics that exhibit activity against a wide range of Gram-positive and Gram-negative bacteria. Their favourable antimicrobial properties and the absence of major adverse effects have led to their extensive use in the therapy of human and animal infections [1][2][3][4] . Unfortunately, like the other antibiotic and as a result of the extensive prescription in conventional formulations, the emergence of microbial resistance has limited their effectiveness. So, other strategies are needed to keep tetracycline's and other antibiotics as resources for the next generation and to restore their initial antimicrobial activity. These strategies are based on the development of new classes of drugs with unique antibacterial mechanisms or new formulations enabling the reduction of amounts of antimicrobials used worldwide. In particular, investigation of new formulations has been carried out in order to overcome the disadvantages resulting from the administration of antibiotics in conventional forms [5][6][7] .The specific addressing of active molecules to the organ, tissue or cell is considered now as a major challenge and promising route for the treatment of various human diseases, including bacterial infections, cancer or genetic diseases [8] . New carrying and targeting approaches for drug delivery have been extensively studied in recent years. Most of them are centered on the development of nano-or micro-scale carrying systems [9][10][11] or specific molecules to improve and maximize drug bioavailability and hence therapeutic effects over a period of time. This highly selective approach would ensure an optimum response from the dosage form which significantly lowers the side effects and reduce treatment's expense.As non-conventional pharmaceutical dos...

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Chitosan and Chitosan Derivatives in Drug Delivery and Tissue Engineering

Cited by 297 publications

References 146 publications

Natural Bio-Polymer and Pharmaceutical Drugs in Textile Processing

Natural Bio-Polymer and Pharmaceutical Drugs in Textile Processing

Preparation of Chitosan-Fe3O4 Nanoparticles by In-situ Co-Precipitation Using Tripolyphosphate / Citrate as Crosslinker and Characterization Using XRD

Preparation and Characterization of Cross-Linked Chitosan Microcapsules for Controlled Delivery of Oxytetracycline

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