Chitosan and Agaricus brasiliensis Polysaccharides Films: A Preliminary Study

Abstract

The known biotechnological properties of chitosan and the recent biological activities attributed to polysaccharides from Agaricus brasiliensis have been of interest to obtain films constituted by these two polymers. The glucans obtained from the mushroom inhibited about 96.5% of the ferrous ion, besides not promoting a significant increase of lactate dehydrogenase enzyme (LDH), which indicates that the polysaccharide is able to inhibit the production of radical species and also presents low cytotoxicity to the biological systems. The results of spectroscopy analyses in the infrared region (FTIR) and X-ray diffraction suggest an existing electrostatic interaction between the substances. A reduction in the films' swelling capacity was observed with an increase in the polysaccharide content in the composition. In addition, scanning electron microscopy (SEM) revealed greater surface density of the films. In convening the biological properties of the substances, it is expected that this study raises interest in evaluating the films and their capacity for healing wounds and burns.

Identifying a Role of Polysaccharides from Agaricus Blazei Murill in Combating Skin Photoaging: The Effect of Antioxidants on Fibroblast Behavior

“…In the past few decades, some studies have proved the biological characteristics of the chemical components in this mushroom's fruiting body, such as anti-tumor, hypolipidemic, anti-herpetic and immunomodulatory properties [6][7][8]. These properties are mainly due to the existence of the β (1→6) and α (1→4) polysaccharide configuration [9,10].…”

Agaricus blazei Murill extract‐loaded in alginate/poly(vinyl alcohol) films prepared by Ca2+ cross‐linking for wound healing applications

“…6) configurations, mainly. [16][17][18][19] In addition, extracts from Agaricus blazei Murill have shown excellent immunomodulatory and antioxidant activities, which may suggest its potential wound healing activity. 20,21 The traditional use of Agaricus blazei Murill is mainly based as an adjuvant in cancer chemotherapy.…”

“…The biological activities of this species have been attributed to the presence of β‐glucans, free or associated with protein fractions. Such polymers can present glycosidic bonds in the α (1 → 4) or β (1 → 6) configurations, mainly 16–19 . In addition, extracts from Agaricus blazei Murill have shown excellent immunomodulatory and antioxidant activities, which may suggest its potential wound healing activity 20,21 …”