Chitin/silk fibroin/TiO2 bio-nanocomposite as a biocompatible wound dressing bandage with strong antimicrobial activity

Mehrabani, Mojtaba Ghanbari; Karimian, Ramin; Rakhshaei, Rasul; Pakdel, Farzaneh; Eslami, Hosein; Fakhrzadeh, Vahid; Rahimi, Mahdi; Salehi, Roya; Kafil, Hossein Samadi

doi:10.1016/j.ijbiomac.2018.05.102

Cited by 116 publications

(47 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alternatively, chitin itself, which has a high tensile strength and modulus, can be used to reinforce chitosan, with both chitin nanofibers [132] and nanocrystals [3] improving the tensile strength of chitosan-based wound dressings. Combinations of chitin and silk fibroin are also popular in wound-dressing research [138][139][140], as are combinations of chitosan and sodium alginate, which has hemostatic and gel-forming properties, keeping the wound moist and preventing fiber entrapment during removal [141,142]. Use of these fibrous nanomaterials in wound dressings not only improves tensile strength, but also typically increases surface area, improving fibroblast attachment and spreading [143], without significantly affecting biocompatibility or barrier properties [3,124].…”

Section: Chitin and Chitosan Nanocomposite Architectures As Wound Drementioning

confidence: 99%

Crab vs. Mushroom: A Review of Crustacean and Fungal Chitin in Wound Treatment

et al. 2020

View full text Add to dashboard Cite

Chitin and its derivative chitosan are popular constituents in wound-treatment technologies due to their nanoscale fibrous morphology and attractive biomedical properties that accelerate healing and reduce scarring. These abundant natural polymers found in arthropod exoskeletons and fungal cell walls affect almost every phase of the healing process, acting as hemostatic and antibacterial agents that also support cell proliferation and attachment. However, key differences exist in the structure, properties, processing, and associated polymers of fungal and arthropod chitin, affecting their respective application to wound treatment. High purity crustacean-derived chitin and chitosan have been widely investigated for wound-treatment applications, with research incorporating chemically modified chitosan derivatives and advanced nanocomposite dressings utilizing biocompatible additives, such as natural polysaccharides, mineral clays, and metal nanoparticles used to achieve excellent mechanical and biomedical properties. Conversely, fungi-derived chitin is covalently decorated with -glucan and has received less research interest despite its mass production potential, simple extraction process, variations in chitin and associated polymer content, and the established healing properties of fungal exopolysaccharides. This review investigates the proven biomedical properties of both fungal- and crustacean-derived chitin and chitosan, their healing mechanisms, and their potential to advance modern wound-treatment methods through further research and practical application.

show abstract

Section: Chitin and Chitosan Nanocomposite Architectures As Wound Drementioning

confidence: 99%

Crab vs. Mushroom: A Review of Crustacean and Fungal Chitin in Wound Treatment

et al. 2020

View full text Add to dashboard Cite

show abstract

“…[22,23] The ligands were designated by L1, L2, L3, L4 and L5 and the complexes by C1, C2, C3, C4 and C5. Antioxidant assessment was performed through the total phenolic content method.…”

Section: Biochemical Applicationsmentioning

confidence: 99%

Oxotitanium(IV) complexes of some bis‐unsymmetric Schiff bases: Synthesis, structural elucidation and biomedical applications

Uddin

Siddique

Mase

et al. 2019

Applied Organom Chemis

View full text Add to dashboard Cite

A number of oxotitanium(IV) complexes of the type TiOL with bisunsymmetric dibasic tetradentate Schiff base (LH 2 ) containing ONNO donor atoms have been synthesized. Mono-Schiff base (OPD-HNP) was prepared by the condensation of 1:3 molar ratio of 2-hydroxy-1-naphthaldehyde (HNP)with o-phenylenediamine (OPD). Dibasic unsymmetric tetradentate diamine Schiff bases were prepared by the reaction of OPD-HNP with 2-hydroxyacetophenone, 2-hydroxypropeophenone, benzoylacetone, acetylacetone and ethylacetoacetate. Further, titanylacetylacetonate was reacted with these ligands to obtain their metal complexes. On the basis of analytical and physiochemical data, the formation of complexes as TiOL was suggested having square pyramidal geometry. Quantum mechanical approach also confirmed this geometry. The assessment of the synthesized ligands and their complexes showed that some behave as good inhibitors of mycelial growth against selected phytopathogic fungi but weak inhibitors against some selected bacteria. A few of them also showed antioxidant properties.

show abstract

“…CS's biocompatibility, biodegradability, hemostatic properties, tissue regeneration acceleration, and antibacterial properties make it as a top candidate for biomedical applications including tissue engineering, wound healing and drug delivery systems . However, the bioactivity of CS is weak and hence biologically active materials like collagen or GEL are added to overcome this problem GEL with Arg–Gly–Asp (RGD)‐like sequence, encourages cell adhesion and migration Since at physiological pH, which is almost neutral, the antibacterial activity of CS is very low antibacterial agents should be added to improve the antibacterial properties of CS in pH 7.4 . It had been shown that, zinc oxide nanoparticles with a size scale of smaller than 100 nm and at the appropriate concentration have powerful antibacterial activity without adverse effect on normal cells .…”

Section: Introductionmentioning

confidence: 99%

In situ synthesized chitosan–gelatin/ZnO nanocomposite scaffold with drug delivery properties: Higher antibacterial and lower cytotoxicity effects

Rakhshaei

Namazi

Hamishehkar

et al. 2019

J of Applied Polymer Sci

Self Cite

View full text Add to dashboard Cite

In this work, chitosan–gelatin/zinc oxide nanocomposite hydrogel scaffolds (CS–GEL/nZnO) were prepared via in situ synthesis of ZnO nanoparticles (nZnO) to reach a scaffold with both inherent antibacterial and drug delivery properties. The prepared nanocomposite hydrogel scaffolds were characterized using scanning electron microscopy, transmission electron microscopy, atomic absorption spectrometer, Fourier transform infrared spectroscopy, and X‐ray diffraction. In addition, swelling, biodegradation, antibacterial, cytocompatibility, and cell attachment of the scaffolds were evaluated. The results showed that the prepared scaffolds had high porosity with a pore size of 50–400 μm and nZnO were well distributed without any agglomeration on the CS–GEL matrix. In addition, the nanocomposite scaffolds showed enhanced swelling, biodegradation, and antibacterial properties. Moreover, the drug delivery studies using naproxen showed that nZnO could control naproxen release. Cytocompatibility of the samples was proved using normal human dermal fibroblast cells (HFF2). In comparison to the previous reports which nZnO were simply added to the matrix of the scaffold, in situ synthesis of nZnO was led to higher antibacterial and lower cytotoxicity effects as a result of well distribution of nZnO in this method. According to the findings, the in situ synthesized CS–GEL/nZnO is strongly recommended for biomedical applications especially skin tissue engineering. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47590.

show abstract

Chitin/silk fibroin/TiO2 bio-nanocomposite as a biocompatible wound dressing bandage with strong antimicrobial activity

Cited by 116 publications

References 62 publications

Crab vs. Mushroom: A Review of Crustacean and Fungal Chitin in Wound Treatment

Crab vs. Mushroom: A Review of Crustacean and Fungal Chitin in Wound Treatment

Oxotitanium(IV) complexes of some bis‐unsymmetric Schiff bases: Synthesis, structural elucidation and biomedical applications

In situ synthesized chitosan–gelatin/ZnO nanocomposite scaffold with drug delivery properties: Higher antibacterial and lower cytotoxicity effects

Contact Info

Product

Resources

About