Chirality in Bioorganosilicon Chemistry

Abstract

Introduction Biological Recognition of Enantiomeric Organosilicon Drugs Biocatalysis as a Method for the Preparation of Optically Active Organosilicon Compounds Concluding Remarks Acknowledgments

Biologically active compounds of semi-metals

“…Alkane analogues silanes are highly reactive with water, and long-chain silanes spontaneously decompose. Molecules incorporating Si-O-Si bonds instead of Si-Si bonds are much more stable; ordinary sand is one such example (Tacke and Wagner, 1998).…”

Synthesis and structural study of precursors of novel methylsilanediols by IR and Raman spectroscopies, single-crystal X-ray diffraction and DFT calculations

“…Chloromethyl(methyl)diphenylsilane (2) Dichloro(chloromethyl)methylsilane (6 mL, 0.041 mol) was added drop-wise over a period of 30 min under an argon atmosphere to a stirred solution of commercial phenylmagnesium bromide in diethyl ether (41 mL, 0.123 mol). The mixture was then refluxed for 16 h and subsequently poured into ice water (150 mL).…”

“…This close chemical analogy has been the inspiration for many studies of silicon as a potential replacement for carbon, particularly in biologically active molecules [1,2]. The most notable example of this is the claim of silanediols as bioisosteres of the hydrated amido group and their application in the development of peptidomimetics as protease inhibitors [3,4].…”

“…Thus, a theoretical-experimental analysis of the molecular structure of this type of silanediol would help achieve a better understanding of the mechanisms of stabilization of the Si(OH) 2 functionality, and which could be related to their potential biological role. For this task, we are working on the preparation of a significant set of relatively simple methylsilanediols which are structurally related to those that have proven biological activity.…”