Chirality‐Driven Transportation and Oxidation Prevention by Chiral Selenium Nanoparticles

Huang, Yanyu; Fu, Yuanting; Li, Mengting; Jiang, Dawei; Kutyreff, Christopher J.; Engle, Jonathan W.; Lan, Xiaoli; Cai, Weibo; Chen, Tianfeng

doi:10.1002/ange.201910615

Cited by 26 publications

(15 citation statements)

References 46 publications

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“…The results of our group and numerous other studies show that ROS could be used as a target or biosignature for the treatment of various diseases (Huang et al, 2017(Huang et al, , 2020Mei et al, 2018;Lai et al, 2019;He et al, 2020;Yang et al, 2020a,c;Zhao et al, 2020). Reactive oxygen species-responsive materials refers to materials capable of responding to those elevated ROS, such as H 2 O 2 , O 2•− , 1 O 2 , and so on.…”

Section: Ros-responsive Nanocarriers and Their Applicationsmentioning

confidence: 78%

“…Se-containing particles can oxidize and change their hydrophilicity in response to ROS. Various Se derivatives of inorganic, organic, and amino acids have been found to exhibit biological activity primarily via antioxidant and pro-oxidant mechanisms (Lai et al, 2019 ; Huang et al, 2020 ). The different oxidation states (−2, 0, +4, +6) and forms of Se contribute to the antioxidant effects of Se.…”

Section: Mechanisms and Effects Of Abnormal Ros Levels On Oxidative Smentioning

confidence: 99%

“…Further mechanistic studies suggested that Se@TE NPs showed its protective effects in the form of selenomethionine (Se-Met) and selenocystine (Se-Cys2), activating selenoenzymes and eliminating the excessive ROS ( Figure 3 ). Recently, in our other Se-related work, we paid attention to the chiral nanomaterials and fabricated a chiral glutathione (GSH) SeNPs (G@SeNPs), coated with GSH on the surface of SeNPs, capable of preventing oxidation damage caused by palmitic acid (Huang et al, 2020 ). G@SeNPs showed ROS-responsive and clearance activities in INS-1 cells.…”

Section: Mechanisms and Effects Of Abnormal Ros Levels On Oxidative Smentioning

confidence: 99%

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Biomedical Application of Reactive Oxygen Species–Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases

Liu

Chen

et al. 2020

Front. Chem.

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Numerous pathological conditions, including cancer, inflammatory diseases, and neurodegenerative diseases, are accompanied by overproduction of reactive oxygen species (ROS). This makes ROS vital flagging molecules in disease pathology. ROS-responsive drug delivery platforms have been developed. Nanotechnology has been broadly applied in the field of biomedicine leading to the progress of ROS-responsive nanoparticles. In this review, we focused on the production and physiological/pathophysiological impact of ROS. Particular emphasis is put on the mechanisms and effects of abnormal ROS levels on oxidative stress diseases, including cancer, inflammatory disease, and neurodegenerative diseases. Finally, we summarized the potential biomedical applications of ROS-responsive nanocarriers in these oxidative stress diseases. We provide insights that will help in the designing of new ROS-responsive nanocarriers for various applications.

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Section: Ros-responsive Nanocarriers and Their Applicationsmentioning

confidence: 78%

Section: Mechanisms and Effects Of Abnormal Ros Levels On Oxidative Smentioning

confidence: 99%

Section: Mechanisms and Effects Of Abnormal Ros Levels On Oxidative Smentioning

confidence: 99%

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Biomedical Application of Reactive Oxygen Species–Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases

Liu

Chen

et al. 2020

Front. Chem.

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“…ROS plays important regulatory roles in chemotherapy 54 , 55 , and the mitochondria are potential source of ROS 56 . Many studies have also disclosed the roles of ROS in the anticancer activities of DOX or DOX encapsulating particles 57 , 58 .…”

Section: Discussionmentioning

confidence: 99%

TRPM8-regulated calcium mobilization plays a critical role in synergistic chemosensitization of Borneol on Doxorubicin

Lai¹,

Liu²,

Hou³

et al. 2020

Theranostics

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Background: Lung cancer has a high mortality rate and is resistant to multiple chemotherapeutics. Natural Borneol (NB) is a monoterpenoid compound that facilitates the bioavailability of drugs. In this study, we investigated the effects of NB on chemosensitivity in the A549 human lung adenocarcinoma cell line and to elucidate therapeutic molecular target of NB. Methods: The chemosensitivity effects of NB in A549 cells were examined by MTT assay. The mechanism of NB action was evaluated using flow cytometry and Western blotting assays. Surface plasmon resonance (SPR) and LC-MS combined analysis (MS-SPRi) was performed to elucidate the candidate molecular target of NB. The chemosensitizing capacity of NB in vivo was assessed in nude mice bearing A549 tumors. Results: NB pretreatment sensitized A549 cells to low doxorubicin (DOX) dosage, leading to a 15.7% to 41.5% increase in apoptosis. This increase was correlated with ERK and AKT inactivation and activation of phospho-p38 MAPK, phospho-JNK, and phosphor-p53. Furthermore, this synergism depends on reactive oxygen species (ROS) generation. MS-SPRi analysis revealed that transient receptor potential melastatin-8 (TRPM8) is the candidate target of NB in potentiating DOX killing potency. Genetically, TRPM8 knock-down significantly suppresses the chemosensitizing effects of NB and inhibits ROS generation through restraining calcium mobilization. Moreover, pretreatment with NB synergistically enhances the anticancer effects of DOX to delay tumor progression in vivo . Conclusions: These results suggest that TRPM8 may be a valid therapeutic target in the potential application of NB, and show that NB is a chemosensitizer for lung cancer treatment.

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“…The human genome contains 25 selenoprotein genes, suggesting that Se plays an important role in the human body. Synthetic Se-containing compounds, including SeNPs and organic Se, have a wide range of biological functions, such as anti-oxidative and anti-tumor effects ( 22 – 24 ). These functions depend on the high level of intracellular reactive oxygen species caused by the high proliferation and metabolism of cancer cells, which increases sensitivity to Se oxidation damage.…”

Section: Introductionmentioning

confidence: 99%

Functionalized Selenium Nanotherapeutics Synergizes With Zoledronic Acid to Suppress Prostate Cancer Cell Growth Through Induction of Mitochondria-Mediated Apoptosis and Cell Cycle S Phase Arrest

Zhao

2021

Front. Oncol.

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The use of established drugs in new therapeutic applications has great potential for the treatment of cancers. Nanomedicine has the advantages of efficient cellular uptake and specific cell targeting. In this study, we investigate using lentinan-functionalized selenium nanoparticles (LET-SeNPs) for the treatment of prostate cancer (PCa). We used assays to demonstrate that a combination of LET-SeNPs and zoledronic acid (ZOL) can reduce PCa cell viability in vitro. Stability and hemocompatibility assays were used to determine the safety of the combination of LET-SeNPs and ZOL. The localization of LET-SeNPs was confirmed using fluorescence microscopy. JC-1 was used to measure the mitochondrial membrane potential, while the cellular uptake, cell cycle and apoptosis were evaluated by flow cytometry. Finally, cell migration and invasion assays were used to evaluate the effects of the combination treatment on cell migration and invasion. Under optimized conditions, we found that LET-SeNPs has good stability. The combination of LET-SeNPs and ZOL can effectively inhibit metastatic PCa cells in a concentration-dependent manner, as evidenced by cytotoxicity testing, flow cytometric analysis, and mitochondria functional test. The enhanced anti-cancer effect of LET-SeNPs and ZOL may be related to the regulation of BCL2 family proteins that could result in the release of cytochrome C from the inner membranes of mitochondria into the cytosol, accompanied by induction of cell cycle arrest at the S phase, leading to irreversible DNA damage and killing of PCa cells. Collectively, the results of this study suggest that the combination of SeNPs and ZOL can successfully inhibit the growth of PCa cells.

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Chirality‐Driven Transportation and Oxidation Prevention by Chiral Selenium Nanoparticles

Cited by 26 publications

References 46 publications

Biomedical Application of Reactive Oxygen Species–Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases

Biomedical Application of Reactive Oxygen Species–Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases

TRPM8-regulated calcium mobilization plays a critical role in synergistic chemosensitization of Borneol on Doxorubicin

Functionalized Selenium Nanotherapeutics Synergizes With Zoledronic Acid to Suppress Prostate Cancer Cell Growth Through Induction of Mitochondria-Mediated Apoptosis and Cell Cycle S Phase Arrest

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