Chirality‐Driven Transportation and Oxidation Prevention by Chiral Selenium Nanoparticles

Abstract

The chirality of nanoparticles directly influences their transport and biological effects under physiological conditions, but the details of this phenomenon have rarely been explored. Herein, chiral GSH‐anchored selenium nanoparticles (G@SeNPs) are fabricated to investigate the effect of their chirality on their transport and antioxidant activity. G@SeNPs modified with different enantiomers show opposite handedness with a tunable circular dichroism signal. Noninvasive positron emission tomography imaging clearly reveals that 64Cu‐labeled l‐G@SeNPs experience distinctly different transport among the major organs from that of their d‐and dl‐counterparts, demonstrating that the chirality of the G@SeNPs influences the biodistribution and kinetics. Taking advantage of the strong homologous cell adhesion and uptake, l‐G@SeNPs have been shown here to effectively prevent oxidation damage caused by palmitic acid in insulinoma cells.

Biomedical Application of Reactive Oxygen Species–Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases

“…The results of our group and numerous other studies show that ROS could be used as a target or biosignature for the treatment of various diseases (Huang et al, 2017(Huang et al, , 2020Mei et al, 2018;Lai et al, 2019;He et al, 2020;Yang et al, 2020a,c;Zhao et al, 2020). Reactive oxygen species-responsive materials refers to materials capable of responding to those elevated ROS, such as H 2 O 2 , O 2•− , 1 O 2 , and so on.…”

“…Se-containing particles can oxidize and change their hydrophilicity in response to ROS. Various Se derivatives of inorganic, organic, and amino acids have been found to exhibit biological activity primarily via antioxidant and pro-oxidant mechanisms (Lai et al, 2019 ; Huang et al, 2020 ). The different oxidation states (−2, 0, +4, +6) and forms of Se contribute to the antioxidant effects of Se.…”

“…Further mechanistic studies suggested that Se@TE NPs showed its protective effects in the form of selenomethionine (Se-Met) and selenocystine (Se-Cys2), activating selenoenzymes and eliminating the excessive ROS ( Figure 3 ). Recently, in our other Se-related work, we paid attention to the chiral nanomaterials and fabricated a chiral glutathione (GSH) SeNPs (G@SeNPs), coated with GSH on the surface of SeNPs, capable of preventing oxidation damage caused by palmitic acid (Huang et al, 2020 ). G@SeNPs showed ROS-responsive and clearance activities in INS-1 cells.…”

TRPM8-regulated calcium mobilization plays a critical role in synergistic chemosensitization of Borneol on Doxorubicin

“…ROS plays important regulatory roles in chemotherapy 54 , 55 , and the mitochondria are potential source of ROS 56 . Many studies have also disclosed the roles of ROS in the anticancer activities of DOX or DOX encapsulating particles 57 , 58 .…”

Functionalized Selenium Nanotherapeutics Synergizes With Zoledronic Acid to Suppress Prostate Cancer Cell Growth Through Induction of Mitochondria-Mediated Apoptosis and Cell Cycle S Phase Arrest

“…The human genome contains 25 selenoprotein genes, suggesting that Se plays an important role in the human body. Synthetic Se-containing compounds, including SeNPs and organic Se, have a wide range of biological functions, such as anti-oxidative and anti-tumor effects ( 22 – 24 ). These functions depend on the high level of intracellular reactive oxygen species caused by the high proliferation and metabolism of cancer cells, which increases sensitivity to Se oxidation damage.…”