Chiral phonons in microcrystals and nanofibrils of biomolecules

Choi, Won Jin; Yano, Keiichi; Cha, Minjeong; Colombari, Felippe Mariano; Kim, Ji-Young; Wang, Yichun; Lee, Sang Hyun; Sun, Kai; Kruger, John M.; Moura, André Farias de; Kotov, Nicholas A.

doi:10.1038/s41566-022-00969-1

Cited by 58 publications

(71 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Future Directionsmentioning

confidence: 99%

“…One of the special cases is represented by chiral phonons. These vibrations are collective mirror-symmetric movements of atomic groups connected by primary and secondary chemical bonds. , Some chiral phonons for special cases of two-dimensional materials have been detected in the IR part of the spectrum, , but numerous chemical structures, exemplified by biological crystals and nanoscale assemblies, are expected to display chiral phonons in the THz range for which TCD will be essential.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Terahertz Circular Dichroism Spectroscopy of Molecular Assemblies and Nanostructures

et al. 2022

Self Cite

View full text Add to dashboard Cite

Chemical, physical, biological and materials engineering disciplines use a variety of chiroptical spectroscopies to probe geometrical and optical asymmetry in molecules and particles. Electronic (ECD) and vibrational (VCD) circular dichroism are the most common of these techniques and collectively enable the studies of electronic and vibronic transitions with energies between 0.1 and 5.0 eV. The vibrational states with characteristic energies in the range of 0.001−0.01 eV carry valuable information about concerted intermolecular motions in molecules and crystals involving multiple atoms. These vibronic transitions located in the terahertz (THz) part of the spectrum become increasingly more important for the chemistry, physics, and biology of complex molecules and materials However, the methodology and hardware of THz circular dichroism (TCD) are much less developed than the chiroptical spectroscopies for ultraviolet, visible, near-and mid infrared photons. Here we provide theoretical foundations, practical implementations, comparative assessments, and exemplary applications of TCD spectroscopy. We show that the sign, intensity, and position of TCD peaks are highly sensitive to the three-dimensional structure and long-range organization of molecular crystals, which offer unique capabilities to study (bio) molecules, their crystals, and nanoscale assemblies and apply the novel data processing methodologies. TCD also offers a convenient toolbox to identify new physical phenomena, such as chiral phonons and their propagation in nanostructured matter. We also discuss the major challenges, emerging opportunities and promising research directions, including broad investigation of chiral phonons observed in chiral (nano) crystals and emerging machine learning methodologies for TCD in biological and nanoscale structures. Ubiquity of low-frequency vibrations with rotational components in biomolecular structures, combined with sharpness of peaks in TCD spectra, enables a variety of technological translations.

show abstract

Section: Future Directionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Terahertz Circular Dichroism Spectroscopy of Molecular Assemblies and Nanostructures

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…THz or submillimeter waves have attracted attention because of their potential applications in time-domain far-infrared spectroscopy, investigations of ultrafast dynamics in materials, , and wireless communication. − Specifically, active modulation of the chiral polarization states of terahertz light is a requirement for a wide range of photonic processes such as noncontact Hall measurements, circular dichroism sensing of chiral molecules and proteins, − and anisotropy imaging . To actively control the polarization, two key properties are required simultaneously for a device: a material with tunable complex refractive and in-plane symmetry breaking to generate phase differences between two orthogonal electromagnetic (EM) waves.…”

Section: Introductionmentioning

confidence: 99%

Broadband Graphene-Based Electro-Optic Chiral Polarization Conversion for Terahertz Pulse Shaping

Chen

Tao

et al. 2022

ACS Photonics

View full text Add to dashboard Cite

Terahertz (THz) radiation is ideally suited for noninvasive testing and short-distance data transmission. Actively controlling the polarization of THz waves is highly desirable in measurement systems. Although significant developments of THz active devices has been achieved through introducing the electromagnetic resonance structure (e.g., metamaterials), the bandwidth is limited. Here, we propose a graphene-based electrically reconfigurable polarization conversion across a broadband THz region (0.3 to 0.9 THz) for controlling the chiral polarization of terahertz pulse. By electrically controlling the graphene conductivity, we can switch the device reflection in-between total internal reflection and metal mirror reflection to realize a frequency-independent phase change, which enables a tunable waveplate with a high dynamic range for manipulating the polarization of THz waves. Because of the frequency-independent modulation property, we achieved tunable chiral polarization THz waveforms in the time domain for the first time, from right-handed to left-handed polarization. This work opens up a new mechanism for designing novel THz modulators for THz circular dichroism.

show abstract

“…An all-dielectric metasurface with the functionalized gold nanoparticles was used to qualitatively detect the concentration of HA antigen [ 15 ]. THz chiroptical spectroscopy enables the registration and attribution of chiral phonons for microscale and nanoscale crystals of amino acids and peptides [ 16 ]. THz spectroscopic detection of amino acids has been significant due to the amino acids play an important role in biomedical, chemical, and food industries [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Experimental Detection and Simulation of Terahertz Spectra of Aqueous L-Arginine

Hou

Wang

et al. 2022

Biosensors

View full text Add to dashboard Cite

Terahertz (THz) wave is a good candidate for biological sample detection, because vibration and rotation energy levels of biomolecule are in THz band. However, the strong absorption of THz wave by water in biological samples hinders its development. In this paper, a method for direct detection of THz absorption spectra of L-arginine suspension was proposed by using a strong field THz radiation source combined with a polyethylene cell with micrometer thickness in a THz time-domain spectroscopy system. And the THz absorption spectrum of L-arginine solution was simulated by the density functional theory and the simulation result is in good agreement with the experimental results. Finally, the types of chemical bond interaction that cause the absorption peak are identified based on the experimental and simulation results. This work paves a way to investigate the THz absorption spectra and intramolecular interactions of aqueous biological samples.

show abstract

Chiral phonons in microcrystals and nanofibrils of biomolecules

Cited by 58 publications

References 50 publications

Terahertz Circular Dichroism Spectroscopy of Molecular Assemblies and Nanostructures

Terahertz Circular Dichroism Spectroscopy of Molecular Assemblies and Nanostructures

Broadband Graphene-Based Electro-Optic Chiral Polarization Conversion for Terahertz Pulse Shaping

Experimental Detection and Simulation of Terahertz Spectra of Aqueous L-Arginine

Contact Info

Product

Resources

About