Chinese version of Montreal Cognitive Assessment Basic for discrimination among different severities of Alzheimer&amp;rsquo;s disease

Huang, Lin; Chen, Keliang; Lin, Bi-Ying; Tang, Le; Zhao, Qianhua; Lv, Yubao; Guo, Qihao

doi:10.2147/ndt.s174293

Cited by 71 publications

(48 citation statements)

References 29 publications

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“…In our cohort, MoCA scores were low in all four groups. However, several Chinese validation studies of the application of MoCA to identify patients with dementia showed lower thresholds than those found in international populations, due to the differences in regional culture and level of education, especially in older patients (Zheng et al, 2012;Huang et al, 2018). The MoCA scores in our study were similar to the data in the above Chinese studies.…”

Section: Discussionsupporting

confidence: 79%

Different Perivascular Space Burdens in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease

Song

et al. 2020

Front. Aging Neurosci.

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Background: Excessive aggregation of α-synuclein is the key pathophysiological feature of Parkinson's disease (PD). Rapid eye movement sleep behavior disorder (RBD) is also associated with synucleinopathies and considered as a powerful predictor of PD. Growing evidence suggests the diminished clearance of α-synuclein may be partly attributable to poor interstitial fluid drainage, which can be reflected by magnetic resonance imaging (MRI)-visible enlarged perivascular space (EPVS). However, the effect of MRI-visible EPVS on iRBD and PD, and their correlation with clinical characteristics remain unclear. Objective: To evaluate the clinical and neuroimaging significance of MRI-visible EPVS in iRBD and PD patients. Methods: We enrolled 33 iRBD patients, 82 PD (with and without RBD) patients, and 35 healthy controls (HCs), who underwent clinical evaluation and 3.0 Tesla MRI. Two neurologists assessed MRI-visible EPVS in centrum semiovale (CSO), basal ganglia (BG), substantia nigra (SN), and brainstem (BS). Independent risk factors for iRBD and PD were investigated using multivariable logistic regression analysis. Spearman analysis was used to test the correlation of MRI-visible EPVS with clinical characteristics of patients. Results: iRBD patients had significantly higher EPVS burdens (CSO, BG, SN, and BS) than PD patients. Higher CSO-EPVS and BS-EPVS burdens were independent risk factors for iRBD. Furthermore, higher CSO-EPVS and SN-EPVS burdens were positively correlated with the severity of clinical symptom in iRBD patients, and higher BG-EPVS burden was positively correlated with the severity of cognitive impairment in PD patients. Conclusion: iRBD and PD patients have different MRI-visible EPVS burdens, which may be related with a compensatory mechanism in glymphatic system. Lower MRI-visible EPVS burden in PD patients may be a manifestation of severe brain waste drainage dysfunction. These findings shed light on the pathophysiologic relationship between iRBD and PD with respect to neuroimaging marker of PD.

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Section: Discussionsupporting

confidence: 79%

Different Perivascular Space Burdens in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease

Song

et al. 2020

Front. Aging Neurosci.

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“…In addition, many studies have shown the distinction between SCD and MCI or AD, by using these neuropsychological assessments, such as MoCA, CDT and AVLT (Fernaeus et al, 2014; Zhao et al, 2015; Vyhnalek et al, 2017; Wang et al, 2019). Their high sensitivity and specificity have also been reported previously, suggesting that those assessments were able to distinguish SCD from MCI and AD (Vyhnalek et al, 2014; Huang et al, 2018; Park et al, 2018; Xu et al, 2018). However, little is known about the diagnostic power of these tools in discriminating SCD ( plus ) and NC.…”

Section: Introductionsupporting

confidence: 75%

Risk Factors and Neuropsychological Assessments of Subjective Cognitive Decline (plus) in Chinese Memory Clinic

Hao

Xing

et al. 2019

Front. Neurosci.

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Background: Since subjective cognitive decline (SCD) was standardized in 2014, many studies have investigated its features. However, the risk of SCD (plus) progressing to AD is much higher, and yet there have been few studies reporting the risk factors and neuropsychological assessment characteristics of SCD (plus). Objective: To characterize SCD (plus) by comparing it with normal control (NC), amnesic mild cognitive impairment (aMCI), and Alzheimer Disease (AD) regarding their demographics, lifestyle, family history of dementia, multimorbidity and the neuropsychological assessments. Methods: A total of 135 participants were recruited, including 23 NC, 30 SCD (plus), 45 aMCI and 37 AD. Descriptive statistics were provided. A logistic regression model was used to analyze the affecting factors of SCD (plus), and finally the Receiver Operating Characteristic (ROC) analysis was applied to distinguish between SCD (plus) and NC. Results: (1) SCD (plus) group was younger than both the aMCI group and AD group. It consisted of more participants with mental work and higher body mass index (BMI) than the AD group. (2) Scores of Auditory Verbal Learning Test-Immediate recall (AVLT-IR) and AVLT-Long delayed recall (AVLT-LR) decreased in the following order: NC→SCD (plus)→aMCI→AD. (3) The Area Under Curve (AUC) for discriminating SCD (plus) and NC group was from 0.673 to 0.838. Conclusion: Aging is an important risk factor of both NC progressing to SCD (plus), and SCD (plus) progressing to aMCI or AD. In addition to aging, lower education level and

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“…However, when screening for MCI or AD, the AUC for the delayed recall test was the largest, which is more conducive to the early recognition of cognitive dysfunction in MCI or AD patients. This is similar to the previous studies by Lin Huang [11] et al The memory index score of the MoCA-BC had high sensitivity and specificity for MCI screening, while the non-memory index score of the MoCA-BC had similar effectiveness for discrimination among MCI, mild AD and moderate AD groups.…”

Section: Discussionsupporting

confidence: 90%

“…The cutoff points to detect MCI or AD have been demonstrated to be different all over the world [6–9]. The Chinese version of the MoCA-B (MoCA-BC), translated with cultural modifications from the original English version, has shown excellent validity and accuracy in distinguishing between NC, MCI, mild and moderate AD among the Chinese elderly with various levels of education [10, 11].…”

Section: Introductionmentioning

confidence: 99%

The items in the Chinese version of the Montreal cognitive assessment basic discriminate among different severities of Alzheimer’s disease

et al. 2019

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BackgroundTo determine whether items of the Chinese version of the Montreal Cognitive Assessment Basic (MoCA-BC) could discriminate among cognitively normal controls (NC), and those with mild cognitive impairment (MCI), mild Alzheimer’s disease (AD), and moderate-severe (AD), as well as their sensitivity and specificity.MethodsMCI (n = 456), mild AD (n = 502) and moderate-severe AD (n = 102) patients were recruited from the memory clinic, Huashan Hospital, Shanghai, China. NC (n = 329) were recruited from health checkup outpatients. Five MoCA-BC item scores were collected in interviews.ResultsThe MoCA-BC orientation test had high sensitivity and specificity for discrimination among MCI, mild AD and moderate-severe AD. The delayed recall memory test had high sensitivity and specificity for MCI screening. The verbal fluency test was efficient for detecting MCI and differentiating AD severity.ConclusionsVarious items of the MoCA-BC can identify MCI patients early and identify the severity of dementia.

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Chinese version of Montreal Cognitive Assessment Basic for discrimination among different severities of Alzheimer’s disease

Cited by 71 publications

References 29 publications

Different Perivascular Space Burdens in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease

Different Perivascular Space Burdens in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease

Risk Factors and Neuropsychological Assessments of Subjective Cognitive Decline (plus) in Chinese Memory Clinic

The items in the Chinese version of the Montreal cognitive assessment basic discriminate among different severities of Alzheimer’s disease

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