Risk Factors and Neuropsychological Assessments of Subjective Cognitive Decline (plus) in Chinese Memory Clinic

Abstract

Background: Since subjective cognitive decline (SCD) was standardized in 2014, many studies have investigated its features. However, the risk of SCD (plus) progressing to AD is much higher, and yet there have been few studies reporting the risk factors and neuropsychological assessment characteristics of SCD (plus). Objective: To characterize SCD (plus) by comparing it with normal control (NC), amnesic mild cognitive impairment (aMCI), and Alzheimer Disease (AD) regarding their demographics, lifestyle, family history of dementia, multimorbidity and the neuropsychological assessments. Methods: A total of 135 participants were recruited, including 23 NC, 30 SCD (plus), 45 aMCI and 37 AD. Descriptive statistics were provided. A logistic regression model was used to analyze the affecting factors of SCD (plus), and finally the Receiver Operating Characteristic (ROC) analysis was applied to distinguish between SCD (plus) and NC. Results: (1) SCD (plus) group was younger than both the aMCI group and AD group. It consisted of more participants with mental work and higher body mass index (BMI) than the AD group. (2) Scores of Auditory Verbal Learning Test-Immediate recall (AVLT-IR) and AVLT-Long delayed recall (AVLT-LR) decreased in the following order: NC→SCD (plus)→aMCI→AD. (3) The Area Under Curve (AUC) for discriminating SCD (plus) and NC group was from 0.673 to 0.838. Conclusion: Aging is an important risk factor of both NC progressing to SCD (plus), and SCD (plus) progressing to aMCI or AD. In addition to aging, lower education level and

Subjective cognitive decline in diabetes: Associations with psychological, sleep, and diabetes‐related factors

“…Unlike our study, Hao et al. (2019) found that increased BMI was associated with decreased SCD symptoms. Such inconsistencies may be partially due to use of different measures for SCD among researchers.…”

“…Obesity is known to be a risk factor for cognitive impairment (Miller & Spencer, 2014), but studies have reported mixed results regarding the associations of BMI with SCD (Hao et al, 2019;Vlachos et al, 2019). Unlike our study, Hao et al (2019) found that increased BMI was associated with decreased SCD symptoms. Such inconsistencies may be partially due to use of different measures for SCD among researchers.…”

“…We observed that increased BMI was associated with increased SCD symptoms in those having less severe cognitive symptoms. Obesity is known to be a risk factor for cognitive impairment (Miller & Spencer, 2014), but studies have reported mixed results regarding the associations of BMI with SCD (Hao et al., 2019; Vlachos et al., 2019). Unlike our study, Hao et al.…”

Altered Frequency-Dependent Brain Activation and White Matter Integrity Associated With Cognition in Characterizing Preclinical Alzheimer’s Disease Stages

“…Subjective cognitive decline (SCD), amnestic mild cognitive impairment (aMCI), and non-amnestic mild cognitive impairment (naMCI) are regarded to be at high risk of converting to Alzheimer’s disease (AD) ( Petersen et al, 2001 , 2009 ; Jessen et al, 2014 ). SCD and aMCI are characterized as preclinical AD stages ( Jessen et al, 2014 ; Rabin et al, 2017 ; Hao et al, 2019 ). While multiple research papers regard naMCI as part of the disease continuum due to diverse aspects ( Yang et al, 2018 ; Xue C. et al, 2019 ), some have reservations ( Vos et al, 2013 , 2015 ; Wilcockson et al, 2019 ).…”

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