Chinese medicinal plants for the potential management of high-altitude pulmonary oedema and pulmonary hypertension

Wang, Tingting; Hou, Jun; Xiao, Wenjing; Zhang, Yaolei; Zhou, Lvjun; Li, Yuan; Yin, Xiaoqiang; Chen, Xin; Hu, Yonghe

doi:10.1080/13880209.2020.1804407

Cited by 13 publications

(2 citation statements)

References 105 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Preparations from Chinese natural plants, such as Allium sativum, Salvia miltiorrhiza Bge. , Withania somnifera, and Rhodiola rosea Linn., were used against PAH ( Wang T. et al, 2020 ; Xiang et al, 2018 ) ( Table 2 ). In vitro evaluation confirmed their anti-inflammatory and antioxidant activities.…”

Section: Preclinical Studies Of Traditional Herbal Medicine For Pulmonary Arterial Hypertension Treatmentmentioning

confidence: 99%

Traditional Herbal Medicine Discovery for the Treatment and Prevention of Pulmonary Arterial Hypertension

Xue

Zhou

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

Pulmonary arterial hypertension (PAH) is characterized by pulmonary artery remodeling that may subsequently culminate in right heart failure and premature death. Although there are currently both non-pharmacological (lung transplantation, etc.) and pharmacological (Sildenafil, Bosentan, and new oral drugs on trial) therapies available, PAH remains a serious and fatal pulmonary disease. As a unique medical treatment, traditional herbal medicine (THM) treatment has gradually exerted its advantages in treating PAH worldwide through a multi-level and multi-target approach. Additionally, the potential mechanisms of THM were deciphered, including suppression of proliferation and apoptosis of pulmonary artery smooth muscle cells, controlling the processes of inflammation and oxidative stress, and regulating vasoconstriction and ion channels. In this review, the effects and mechanisms of the frequently studied compound THM, single herbal preparations, and multiple active components from THM are comprehensively summarized, as well as their related mechanisms on several classical preclinical PAH models. It is worth mentioning that sodium tanshinone IIA sulfonate sodium and tetramethylpyrazine are under clinical trials and are considered the most promoting medicines for PAH treatment. Last, reverse pharmacology, a strategy to discover THM or THM-derived components, has also been proposed here for PAH. This review discusses the current state of THM, their working mechanisms against PAH, and prospects of reverse pharmacology, which are expected to facilitate the natural anti-PAH medicine discovery and development and its bench-to-bedside transformation.

show abstract

Section: Preclinical Studies Of Traditional Herbal Medicine For Pulmonary Arterial Hypertension Treatmentmentioning

confidence: 99%

Traditional Herbal Medicine Discovery for the Treatment and Prevention of Pulmonary Arterial Hypertension

Xue

Zhou

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…We focused on natural products, which have been shown to have unique advantages in treating PH. This is because they have a multitarget and multipathway synergistic effect in treating the disease, with significant efficacy in inhibiting pulmonary vascular remodeling (PVR) and protecting right heart function [ 11 , 12 , 13 ]. The specific mechanism may be closely related to improving inflammatory response, inhibiting oxidative stress, reducing cell apoptosis resistance, and regulating abnormal ion channels and collagen deposition [ 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Natural Products for the Treatment of Pulmonary Hypertension: Mechanism, Progress, and Future Opportunities

Zeng

Wang

Cui

et al. 2023

CIMB

View full text Add to dashboard Cite

Pulmonary hypertension (PH) is a lethal disease due to the remodeling of pulmonary vessels. Its pathophysiological characteristics include increased pulmonary arterial pressure and pulmonary vascular resistance, leading to right heart failure and death. The pathological mechanism of PH is complex and includes inflammation, oxidative stress, vasoconstriction/diastolic imbalance, genetic factors, and ion channel abnormalities. Currently, many clinical drugs for the treatment of PH mainly play their role by relaxing pulmonary arteries, and the treatment effect is limited. Recent studies have shown that various natural products have unique therapeutic advantages for PH with complex pathological mechanisms owing to their multitarget characteristics and low toxicity. This review summarizes the main natural products and their pharmacological mechanisms in PH treatment to provide a useful reference for future research and development of new anti-PH drugs and their mechanisms.

show abstract

Therapeutic Applications of Herbal Medicines for the Prevention and Management of Cancer

Pathak,

Pandey,

Singh

et al. 2023

Reference Series in Phytochemistry

View full text Add to dashboard Cite

Chinese medicinal plants for the potential management of high-altitude pulmonary oedema and pulmonary hypertension

Cited by 13 publications

References 105 publications

Traditional Herbal Medicine Discovery for the Treatment and Prevention of Pulmonary Arterial Hypertension

Traditional Herbal Medicine Discovery for the Treatment and Prevention of Pulmonary Arterial Hypertension

Natural Products for the Treatment of Pulmonary Hypertension: Mechanism, Progress, and Future Opportunities

Therapeutic Applications of Herbal Medicines for the Prevention and Management of Cancer

Contact Info

Product

Resources

About