This paper explores the recent industrial relocation of Hong Kong manufacturing firms in the Pearl River Delta. Based on a combination of recent surveys, four in-depth case studies and nearly 20 firm interviews through the end of 2008, the paper argues that in response to a dynamic business environment in the region, some Hong Kong manufacturing firms in the PRD are forced to design new spatial strategies. The paper also identifies the different relocation strategies adopted by Hong Kong manufacturing firms, namely, total relocation, stratified relocation and ''pseudo relocation''. The industrial space of Hong Kong manufacturing firms will be expanded beyond the PRD. In addition, the new round of relocation of Hong Kong manufacturers is a response to the initiative ushered in by the provincial and local governments in order to achieve the objectives of industrial upgrading, sustainable environment and regional balanced development.