Chinese Herbal Medicine for Systemic Lupus Erythematosus: A Systematic Review and Meta-analysis of Randomized, Placebo-Controlled Trials

Wang, Ying; Han, Mei; Pedigo, Christopher E.; Xie, Zhimin; Wang, Weijie; Liu, Jianping

doi:10.1007/s11655-021-3497-0

Cited by 13 publications

(9 citation statements)

References 29 publications

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“…Using the CHM, easy to assume that herbal medicines are risk-free just because they're allnatural. Adverse effects of a severe nature have also been documented [22] . Acupuncture when administered by a trained professional using single-use, disposable needles, the hazards associated with acupuncture are minimal.…”

Section: Resultsmentioning

confidence: 99%

Therapeutic Effect of Systemic Lupus Erythematosus Traditional Chinese Medicine Based on the Deoxyribonucleic Acid Methylation of Interferon-Induced Genes

Yang¹,

Chen²,

Cao³

et al. 2023

IJPS

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Systemic lupus erythematosus are all involved autoimmune illnesses with similar clinical, genetic and pathogenic characteristics. However, it is still uncertain what characteristics these disorder's deoxyribonucleic acid methylation patterns have in common. To determine the typical methylation patterns of autoimmune illnesses, we undertook to analyze the methylation data for numerous inflammatory disorders in a unified manner, which included samples from systemic lupus erythematosus. In clusters of differentiation 4 + T cells, we discovered 15 289 locations that were differently methylated in patients with various autoimmune diseases compared to controls in medical imaging. In addition to this, the artificial intelligence plays a greater role in predicting the model of therapeutic effect of systemic lupus erythematosus. We determined that genes involved in the type I interferon pathway were significantly enriched at the regions that displayed the most substantial differential methylation. Interferon-induced protein 44-like is another interferon-related gene, but it is not annotated by gene ontology. The results showed that clusters of differentiation 4 + T cells from systemic lupus erythematosus patients often had hypo methylation of interferon-related genes; moreover interferonrelated gene deoxyribonucleic acid methylation patterns may be useful diagnostic indicators for systemic lupus erythematosus.

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Section: Resultsmentioning

confidence: 99%

Therapeutic Effect of Systemic Lupus Erythematosus Traditional Chinese Medicine Based on the Deoxyribonucleic Acid Methylation of Interferon-Induced Genes

Yang¹,

Chen²,

Cao³

et al. 2023

IJPS

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“…Figure 1 summarizes the currently used CLE treatments derived from natural products and their targets. Other rheumatologic conditions have been treated with folk medicine ( Salmón, 2020 ), herbalism ( Yarnell and Abascal, 2008 ), and Traditional Chinese Medicine (TCM) ( Chang et al, 1997 ; Ma et al, 2016 ; Wang Y. et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Medicinal Plant Extracts and Natural Compounds for the Treatment of Cutaneous Lupus Erythematosus: A Systematic Review

et al. 2022

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Cutaneous lupus erythematosus (CLE) is a group of autoimmune connective tissue disorders that significantly impact quality of life. Current treatment approaches typically use antimalarial medications, though patients may become recalcitrant. Other treatment options include general immunosuppressants, highlighting the need for more and more targeted treatment options. The purpose of this systematic review was to identify potential compounds that could be repurposed for CLE from natural products since many rheumatologic drugs are derived from natural products, including antimalarials. This study was registered with PROSPERO, the international prospective register of systematic reviews (registration number CRD42021251048). We comprehensively searched Ovid Medline, Cochrane Library, and Scopus databases from inception to April 27th, 2021. These terms included cutaneous lupus erythematosus; general plant, fungus, bacteria terminology; selected plants and plant-derived products; selected antimalarials; and JAK inhibitors. Our search yielded 13,970 studies, of which 1,362 were duplicates. We screened 12,608 abstracts, found 12,043 to be irrelevant, and assessed 565 full-text studies for eligibility. Of these, 506 were excluded, and 59 studies were included in the data extraction. The ROBINS-I risk of bias assessment tool was used to assess studies that met our inclusion criteria. According to our findings, several natural compounds do reduce inflammation in lupus and other autoimmune skin diseases in studies using in vitro methods, mouse models, and clinical observational studies, along with a few randomized clinical trials. Our study has cataloged evidence in support of potential natural compounds and plant extracts that could serve as novel sources of active ingredients for the treatment of CLE. It is imperative that further studies in mice and humans are conducted to validate these findings.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=251048.

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“…Previous clinical and experimental studies have shown that TGP can alleviate typical symptoms, increase the expression rate of CD4 + CD25+T cells, regulate the TLR9/MyD88/NF-KB signaling pathway, reduce the levels of CD40 + , sVCAM-1, IL-18, VEGF, and MMP-3, and inhibit the expression of inflammatory factors, playing an immunomodulatory and anti-SLE renal damage role. This indicates that TGP may be a potential new therapeutic agent for the modern treatment of SLE ( Wu et al, 2020 ; Wang et al, 2021 ; Wu et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of total glucosides of paeony in the treatment of systemic lupus erythematosus: A systematic review and meta-analysis

Gong

Guo

et al. 2022

Front. Pharmacol.

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Background: Total glucosides of paeony (TGP), extracted from the Chinese medicine Paeonia lactiflora Pall., have been proven to be effective in various autoimmune diseases. We aim to systematically evaluate the efficacy and safety of TGP combined with different conventional therapeutic agents in the treatment of systemic lupus erythematosus (SLE).Methods: Eight databases were searched for randomized controlled studies of TGP for SLE. The search time was set from the establishment of the databases to March 2022. The risk of bias was assessed by the Cochrane Evaluation Manual (5.1.0), RevMan 5.3 software was used for meta-analysis, and the certainty of the evidence was assessed by the GRADE methodology.Results: A total of 23 articles were included, including 792 patients overall in the treatment group and 781 patients overall in the control group. The meta-analysis results showed that TGP combined with conventional treatments was superior to the conventional treatments in reducing the SLE disease activity and the incidence of adverse reactions (SMDTGP+GC+CTX = −1.98, 95% Cl = [−2.50, −1.46], p < 0.001; SMDTGP+GC+HCQ = −0.65, 95% Cl = [−1.04, −0.26], p <0.001; SMDTGP+GC+TAC = −0.94, 95% Cl = [−1.53, -0.34], p < 0.05; SMDTGP+GC = −1.00, 95% Cl = [−1.64, −0.36], p < 0.05; and RRTGP+GC+CTX = 0.37, 95% Cl = [0.21, 0.64], p < 0.001). The results also showed that TGP helped improve other outcomes related to SLE disease activity, such as complement proteins (C3 and C4), immunoglobulins (IgA, IgM and, IgG), ESR, CRP, 24 h urine protein, and recurrence rate. In addition, TGP may also be effective in reducing the average daily dosage of glucocorticoids (GCs) and the cumulative dosage of cyclophosphamide (CTX). The certainty of the evidence was assessed as moderate to low.Conclusion: TGP is more effective and safer when used in combination with different conventional therapeutic agents. It helped reduce the disease activity of SLE and the incidence of adverse reactions. However, we should be cautious about these conclusions as the quality of the evidence is poor. Future studies should focus on improving the methodology. High-quality randomized controlled trials (RCTs) will be necessary to provide strong evidence for the efficacy of TGP for SLE.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO, identifier CRD42021272481

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Chinese Herbal Medicine for Systemic Lupus Erythematosus: A Systematic Review and Meta-analysis of Randomized, Placebo-Controlled Trials

Cited by 13 publications

References 29 publications

Therapeutic Effect of Systemic Lupus Erythematosus Traditional Chinese Medicine Based on the Deoxyribonucleic Acid Methylation of Interferon-Induced Genes

Therapeutic Effect of Systemic Lupus Erythematosus Traditional Chinese Medicine Based on the Deoxyribonucleic Acid Methylation of Interferon-Induced Genes

Medicinal Plant Extracts and Natural Compounds for the Treatment of Cutaneous Lupus Erythematosus: A Systematic Review

Efficacy and safety of total glucosides of paeony in the treatment of systemic lupus erythematosus: A systematic review and meta-analysis

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