Chinese familial central precocious puberty with hyperuricemia due to recurrent DLK1 mutation: Case report and review of the literature

Abstract

The beginning of puberty is influenced by many factors, among which genetic factors are the most prominent (Aguirre & Eugster, 2018). The genetic contribution to pubertal timing is supported by the strong correlation between the ages that children and their parents begin puberty. Twin studies demonstrated a higher concordance of the timing of development of secondary sexual characteristics, including menarche in girls, in monozygotic compared to dizygotic twins, which also provides the basis for gene regulation of puberty onset (Dvornyk & Waqar