Chin-Shan Community Cardiovascular Cohort in Taiwan–baseline data and five-year follow-up morbidity and mortality

Lee, Yuan‐Teh; Lin, Ruey S.; Sung, Fung Chang; Yang, Chi-Yu; Chien, Kuo–Liong; Chen, Wen‐Jone; Su, Ta‐Chen; Hsu, Hsiu-Ching; Huang, Yuh-Chen

doi:10.1016/s0895-4356(00)00198-0

Cited by 96 publications

(107 citation statements)

References 31 publications

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“…Information about anthropometry, lifestyle and medical conditions was assessed by the interview questionnaires in 2-year cycles for the initial 6 years and the validity and reproducibility of the collected data and measurements have been reported in detail elsewhere. 17 The response rate of the cohort participants was 85.7% at the end of the study.…”

Section: Methodsmentioning

confidence: 96%

“…[16][17] Briefly, the Chin-Shan Community Cardiovascular Cohort study began in 1990 by recruiting 1703 men and 1899 women of Chinese ethnicity aged 35 years old and above from ChinShan township. Information about anthropometry, lifestyle and medical conditions was assessed by the interview questionnaires in 2-year cycles for the initial 6 years and the validity and reproducibility of the collected data and measurements have been reported in detail elsewhere.…”

Section: Methodsmentioning

confidence: 99%

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Prediction models for the risk of new-onset hypertension in ethnic Chinese in Taiwan

Chien

Hsu

et al. 2010

J Hum Hypertens

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Prediction model for hypertension risk in Chinese is still lacking. We aimed to propose prediction models for new-onset hypertension for ethnic Chinese based on a prospective cohort design on community, which recruited 2506 individuals (50.8% women) who were not hypertensive at the baseline . Total 1029 cases of new-onset hypertension developed during a median of 6.15 (interquartile range, 4.04-9.02) years of followup. In the clinical model, gender (2 points), age (8 points), body mass index (10 points), systolic blood pressure (19 points) and diastolic blood pressure (7 points) were assigned. The biochemical measures, including white blood count (3 points), fasting glucose (1 point), uric acid (3 points), additional to above clinical variables, were constructed. The areas under the receiver operative characteristic curves (AUCs) were 0.732 (95% confidence interval (CI), 0.712-0.752) for the point-based clinical model and 0.735 (95% CI, 0.715-0.755) for the point-based biochemical model. The coefficient-based models had a good performance (AUC, 0.737-0.741). The point-based clinical model had a similar net reclassification improvement as the coefficient-based clinical model (P ¼ 0.30), and had a higher improvement than the point-based biochemical model (P ¼ 0.015). We concluded that the point-based clinical model could be considered as the first step to identify high-risk populations for hypertension among Chinese.

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Section: Methodsmentioning

confidence: 96%

Section: Methodsmentioning

confidence: 99%

Prediction models for the risk of new-onset hypertension in ethnic Chinese in Taiwan

Chien

Hsu

et al. 2010

J Hum Hypertens

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“…The National Taiwan University Hospital Committee Review Board approved the study protocol, details of which have been published previously [19,20]. Briefly, the Chin-Shan Community Cardiovascular Cohort Study began in 1990 by recruiting 1,703 men and 1,899 women of Chinese ethnicity aged 35 years old or older from the Chin-Shan township, 30 km north of metropolitan Taipei, Taiwan.…”

Section: Study Design and Participantsmentioning

confidence: 99%

A prediction model for type 2 diabetes risk among Chinese people

et al. 2008

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Aims/hypothesis A range of prediction rules for the onset of type 2 diabetes have been proposed. However, most studies have been conducted in white groups and it is not clear whether these models apply to Asian populations. The purpose of this study was to construct a simple points model for predicting incident diabetes among Chinese people.Methods We estimated the 10 year risk of diabetes in a cohort study of middle-aged and elderly participants who were free from diabetes at baseline. Cox regression coefficients were used to construct the simple points model and the discriminatory ability of the resulting prediction rule was determined using AUC and net reclassification improvement and integrated discrimination improvement statistics. Fivefold random splitting was used to test the internal validity and obtain bootstrap estimates of the AUC. Results Of the 2,960 participants without diabetes at the baseline examination, 548 developed type 2 diabetes during a median 10 year follow-up period. Age (four points), elevated fasting glucose (11 points), body mass index (eight points), triacylglycerol (five points), white blood cell count (four points) and a higher HDL-cholesterol (negative four points) were found to strongly predict diabetes incidence in a multivariate model. The estimated AUC for the model was 0.702 (95% CI 0.676-0.727). This model performed better than existing prediction models developed in other populations, including the Prospective Cardiovascular Münster, Cambridge, San Antonia and Framingham models for diabetes risk. Conclusions/interpretation We have constructed a model for predicting the 10 year incidence of diabetes in Chinese people that could be useful for identifying individuals at high risk of diabetes in the Chinese population.

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“…[19][20][21] In brief, the study was started in 1990 with an initial cohort 3,602 participants, who were recruited on the basis of official registrations. This study was approved by the institutional review boards of the National Taiwan University.…”

Section: Study Design and Populationmentioning

confidence: 99%

Use of Serum Homocysteine to Predict Stroke, Coronary Heart Disease and Death in Ethnic Chinese 12-Year Prospective Cohort Study

Sun

Chien

Hsu

et al. 2009

Circ J

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Background: Prospective data about the association between serum total homocysteine (Hcy) and vascular disease in Asia is limited because few investigations have evaluated the cutpoint of Hcy for predicting the risk of vascular disease and death. Methods and Results: A community-based prospective cohort study of 2,009 participants, who were free from stroke, coronary heart disease (CHD) and cancer at baseline in 1994 were followed up to 2007 (median 11.95 years); there were 114 documented cases of stroke, 95 of CHD and 380 deaths. Cox proportional hazard model was used to examine the association between Hcy and the incidence of stroke, CHD, and all-cause death. The receiveroperating characteristic curve was performed for determining the cutpoint of Hcy in risk prediction. Hcy levels remained significantly associated with cardiovascular events and death in fully adjusted models. Participants with Hcy >9.47 μmol/L (sensitivity 81.1%, specificity 54.3%) had a 2.3-fold risk for cardiovascular events (95% confidence interval (CI), 1.24-4.18, P=0.008), and participants with Hcy >11.84 μmol/L (sensitivity 49.7%, specificity 84.0%) had a 2.4-fold risk for death (95%CI, 1.76-3.32, P<0.0001). Conclusions: Hcy was significantly related to cardiovascular events and all-cause death, with the best cutpoint values as 9. 47 and 11.84, respectively. (Circ J 2009; 73: 1423 -1430

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Chin-Shan Community Cardiovascular Cohort in Taiwan–baseline data and five-year follow-up morbidity and mortality

Cited by 96 publications

References 31 publications

Prediction models for the risk of new-onset hypertension in ethnic Chinese in Taiwan

Prediction models for the risk of new-onset hypertension in ethnic Chinese in Taiwan

A prediction model for type 2 diabetes risk among Chinese people

Use of Serum Homocysteine to Predict Stroke, Coronary Heart Disease and Death in Ethnic Chinese 12-Year Prospective Cohort Study

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