Chimyl Alcohol Suppresses PGE&lt;sub&gt;2&lt;/sub&gt; Synthesis by Human Epidermal Keratinocytes through the Activation of PPAR-γ

Yokota, Mami; Yahagi, Shoichi; Tokudome, Yoshihiro; Hashimoto, Masaki

doi:10.5650/jos.ess17157

Cited by 5 publications

(4 citation statements)

References 27 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, curcumin was found to suppress the onset of skin disorders during diabetes, suggesting that this may be due to its anti-inflammatory effect [44]. A peroxisome proliferator-activated receptor γ (PPARγ) agonist used as an insulin secretagogue was found to show anti-inflammatory effects in addition to its effect in increasing AQP3 [45][46][47][48][49] and may be useful for diabetic xerosis. In the future, the application of these drugs in diabetic xerosis is expected.…”

Section: Discussionmentioning

confidence: 99%

Role of Cutaneous Aquaporins in the Development of Xeroderma in Type 2 Diabetes

et al. 2021

View full text Add to dashboard Cite

Xeroderma is induced by diabetes, reducing patients’ quality of life. We aimed to clarify the roles of cutaneous water channel aquaporin-3 (AQP3) in diabetic xeroderma using type 2 diabetes model db/db mice. Blood glucose levels were unchanged in 5-week-old db/db mice compared to db/+ mice (control mice), but the pathophysiology of type 2 diabetes was confirmed in 12-week-old db/db mice. The dermal water content and AQP3 expression in 5-week-old db/db mice were almost the same as those in the control mice. On the other hand, in 12-week-old db/db mice, the dermal water content and AQP3 expression were significantly decreased. The addition of glucose to HaCaT cells had no effect on AQP3, but tumor necrosis factor-α (TNF-α) decreased the AQP3 expression level. Blood TNF-α levels or skin inflammation markers in the 12-week-old db/db mice were significantly higher than those in control mice. AQP3 levels in the skin were decreased in type 2 diabetes, and this decrease in AQP3 may be one of the causes of xeroderma. Therefore, a substance that increases AQP3 may be useful for improving xeroderma. Additionally, a decrease in skin AQP3 may be triggered by inflammation. Therefore, anti-inflammatory drugs may be effective as new therapeutic agents for diabetic xerosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Role of Cutaneous Aquaporins in the Development of Xeroderma in Type 2 Diabetes

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Furthermore, several studies suggest that the Nrf2 and PPARγ pathways are mutually regulated by enhancing each other’s protein expression [ 20 , 37 ]. The knockdown of Nrf2 decreases PPARγ expression [ 38 ], whereas PPARG knockdown decreases Nrf2 expression [ 21 , 39 ]. This study showed that PPARG was significantly upregulated in GDS-23-treated cells.…”

Section: Discussionmentioning

confidence: 99%

Noncanonical mechanism of Nrf2 activation by diacylglycerol polyethylene glycol adducts in normal human epidermal keratinocytes

Miyoshi,

Keller,

Ashino

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

Polyethylene glycol-23 glyceryl distearate (GDS-23), a diacylglycerol polyethylene glycol adduct, forms niosomes with a liposome-like structure and functions as an active ingredient in drug delivery systems. In addition, it upregulates antioxidant proteins such as heme oxygenase 1 and NAD(P)H-quinone dehydrogenase 1 in cells. However, the activation of nuclear factor E2-related factor-2 (Nrf2), which plays a role in inducing the expression of antioxidant proteins, and its protective effects induced by GDS-23 treatment against oxidative stress have not been elucidated. This study aimed at verifying the activation of Nrf2 by GDS-23 and clarifying its underlying mechanisms, and investigated whether GDS-23 protects against hydroquinone-induced cytotoxicity. Normal human epidermal keratinocytes were treated with GDS-23. Real-time reverse transcription-polymerase chain reaction, western blotting, and immunostaining were used to investigate the mechanism of Nrf2 activation, and neutral red assay was performed to evaluate cytotoxicity. GDS-23-treated cells showed an increase in antioxidant protein levels and stabilization of Nrf2 in the nucleus. During Nrf2 activation, p62, an autophagy-related adaptor protein, was phosphorylated at Ser349. Inhibition of the interaction between the phosphorylated p62 and Kelch-like ECH-associated protein 1 significantly suppressed the GDS-23-mediated induction of antioxidant protein expression. In addition, hydroquinone-induced cell toxicity was significantly attenuated by GDS-23. GDS-23 induced the intracellular antioxidant system by activating Nrf2 in a p62 phosphorylation-dependent manner without generating oxidative stress in the cells. GDS-23 may be applied as a multifunctional material for drug delivery system that enhances internal antioxidant systems.

show abstract

“…Among them is the ability to promote important stimulation for the immunological control, production of antibodies, and anti-inammatory effects. 9,10 An investigation in the eld of medicine on patients diagnosed with cervical cancer showed great recession on the size of the tumor when submitted to radiation treatment alongside the administration of mixtures of natural 1-O-alkylglycerols 1, 2, 3. [11][12][13] Furthermore, recent studies have been suggesting the use of these 1-O-alkylglycerols 1, 2, and 3 as anti-fouling agents and evaluating their efficiency towards fouling processes on metallic surfaces of ships, platforms, and oil pipelines.…”

Section: Introductionmentioning

confidence: 99%

“…Among them is the ability to promote important stimulation for the immunological control, production of antibodies, and anti-inflammatory effects. 9,10 …”

Section: Introductionmentioning

confidence: 99%