Role of Cutaneous Aquaporins in the Development of Xeroderma in Type 2 Diabetes

Ikarashi, Nobutomo; Mizukami, Nanaho; Pei, Chenchen; Uchino, Ryogo; Fujisawa, Izumi; Fukuda, Natsuko; Kon, Risako; Sakai, Hiroyasu; Kamei, Junzo

doi:10.3390/biomedicines9020104

Cited by 12 publications

(14 citation statements)

References 48 publications

(71 reference statements)

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“…24 One of the causes of pruritus in DM is severe skin xerosis, as xerosis cutis occur in one of four diabetic patients as reported by Ikarashi, 2021. 25 However, pruritus in our diabetic patients was not associated with xerosis.…”

Section: Discussioncontrasting

confidence: 45%

Clinical and Laboratory Characteristics of Elderly Patients with Pruritus

Aboeldahab

Khalil

El-Dawla

2021

CCID

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Introduction For elderly, pruritus is considered the most common complaint in outpatient clinic. Pruritus occurs in association with primary skin disorders and can also be caused by many diseases and drugs. The aim of the work was to study clinical and laboratory characteristics of elderly patients with pruritus in Sohag, Egypt. Patients and Methods A cross-sectional study was conducted on 225 patients aged ≥60 years of both sexes complaining of pruritus and 160 age- and sex-matched patient group complaining of non-pruritic dermatological diseases. CBC, ESR, renal function tests, serology for HBV and HCV and blood glucose levels were done routinely in all patients (both groups). Skin biopsy was done in some selected cases. Results The mean duration of pruritus was 4.23 ± 4.9 months and was generalized in 73.8% of cases with moderate severity in 35.1% with winter exacerbation in 20%. Dermatological causes of pruritus were detected in 54.2%, followed by systemic causes in 29.8%. Eczema was the most common skin cause of senile itching in 33.7%, while renal diseases were the most common systemic cause in 46.2%. Conclusion Senile pruritus is a common problem in elderly. Early and proper management is mandatory to improve their quality of life.

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Section: Discussioncontrasting

confidence: 45%

Clinical and Laboratory Characteristics of Elderly Patients with Pruritus

Aboeldahab

Khalil

El-Dawla

2021

CCID

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“…In addition, the expression level of AQP3 in the skin of aged mice was lower than that in young mice, suggesting that AQP3 may be involved in the decrease in dermal water content in old age [ 28 ]. Furthermore, AQP3 is decreased at the onset of various pathological conditions (diabetes mellitus [ 29 , 30 ], vitiligo [ 31 , 32 ], and psoriasis [ 33 ]) in which dry skin is observed. In addition, when mice are treated with the anticancer drug, which causes marked dry skin as a side effect, dry skin and a decrease in AQP3 were also observed [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Cannabidiol Application Increases Cutaneous Aquaporin-3 and Exerts a Skin Moisturizing Effect

et al. 2021

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Cannabidiol (CBD) is a major nonpsychotropic component of Cannabis sativa with various pharmacological activities. In this study, we investigated the skin moisturizing effect of CBD and its mechanism. A 1% CBD solution was applied daily to skin of HR-1 hairless (Seven-week-old, male) for 14 days. The dermal water content in CBD-treated mice was significantly increased compared to that in the control group. Furthermore, no inflammatory reaction in the skin and no obvious skin disorders were observed. The mRNA expression levels of loricrin, filaggrin, collagen, hyaluronic acid degrading enzyme, hyaluronic acid synthase, ceramide degrading enzyme, and ceramide synthase in the skin were not affected by the application of CBD. However, only aquaporin-3 (AQP3), a member of the aquaporin family, showed significantly higher levels in the CBD-treated group than in the control group at both the mRNA and protein levels. It was revealed that CBD has a moisturizing effect on the skin. In addition, it is possible that increased expression of AQP3, which plays an important role in skin water retention, is a contributor to the mechanism. CBD is expected to be developed in the future as a cosmetic material with a unique mechanism.

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“…In addition, lower skin AQP3 levels are observed in old mice than in young mice, suggesting that AQP3 loss is involved in skin dryness in old age [ 38 ]. Cutaneous AQP3 levels are also decreased at the onset of diabetes mellitus [ 23 , 39 ], vitiligo [ 40 , 41 ], and psoriasis [ 42 ], in which dry skin is observed. Moreover, skin disorders such as dry skin caused by epidermal growth factor receptor inhibitor administration may also be associated with decreased skin expression of AQP3 [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Samples were prepared from mouse skin and HaCaT cells for western blotting in the same manner as previously reported [ 23 , 24 ]. The protein concentration was measured by the bicinchoninic acid method using bovine serum albumin as a standard.…”

Section: Methodsmentioning

confidence: 99%

Wound-Healing and Skin-Moisturizing Effects of Sasa veitchii Extract

et al. 2021

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Sasa veitchii (S. veitchii) is a traditional herb derived from the bamboo genus, which is collectively called Kumazasa. Although Kumazasa extract is believed to have various effects on the skin, there is little scientific evidence for these effects. In this study, we aimed to obtain scientific evidence regarding the wound-healing and skin-moisturizing effects of Kumazasa extract. Kumazasa extract was applied to the skin of a mouse wound model for 14 days, and the wound area and dermal water content were measured. Mice treated with Kumazasa extract had smaller wound areas than control mice. The dermal water content in the Kumazasa extract-treated group was significantly higher than that in the control group. The mRNA and protein expression levels of cutaneous aquaporin-3 (AQP3), which is involved in wound healing and increases in dermal water content, were significantly increased by treatment with Kumazasa extract. Kumazasa extract-treated HaCaT cells exhibited significantly higher AQP3 expression and p38 mitogen-activated protein kinase (MAPK) phosphorylation than control cells. With continuous application, Kumazasa extract increases AQP3 expression and exerts wound-healing and moisturizing effects. The increase in AQP3 expression elicited by Kumazasa extract may be due to enhancement of transcription via activation of p38 MAPK signaling.

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Role of Cutaneous Aquaporins in the Development of Xeroderma in Type 2 Diabetes

Cited by 12 publications

References 48 publications

Clinical and Laboratory Characteristics of Elderly Patients with Pruritus

Clinical and Laboratory Characteristics of Elderly Patients with Pruritus

Cannabidiol Application Increases Cutaneous Aquaporin-3 and Exerts a Skin Moisturizing Effect

Wound-Healing and Skin-Moisturizing Effects of Sasa veitchii Extract

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