Children’s vaccines do not induce cross reactivity against SARS-CoV

Yu, Yang; Jin, Huali; Chen, Ze; Yu, Qingling; Yijie, J; Sun, Xiao-Lin; Wang, Bin

doi:10.1136/jcp.2006.038893

Cited by 22 publications

(24 citation statements)

References 15 publications

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“…Because children experience less severe disease during SARS-CoV-1 infection than adults, it was hypothesized that childhood vaccination with non-CoVs provided cross-protection against SARS-CoV-1. However, binding and neutralizing antibodies and T cell responses induced by routine childhood vaccinations (AMPV, BCG, DPT, HBV, HIB, JEV, MMRV [and MV, RV], OPV, PI, SV, VV [varicella vaccine]) did not cross-react with SARS-CoV-1 in experimentally inoculated mice 78 .…”

Section: Infection With Endemic Hcovs Produces Little Cross-reactivitmentioning

confidence: 99%

A systematic review of antibody mediated immunity to coronaviruses: antibody kinetics, correlates of protection, and association of antibody responses with severity of disease

Huang

García‐Carreras

Hitchings

et al. 2020

Preprint

310

383

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The duration and nature of immunity generated in response to SARS-CoV-2 infection is unknown. Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time. The timescale of protection is a critical determinant of the future impact of the pathogen. The presence or absence of protective immunity due to infection or vaccination (when available) will affect future transmission and illness severity. The dynamics of immunity and nature of protection are relevant to discussions surrounding therapeutic use of convalescent sera as well as efforts to identify individuals with protective immunity. Here, we review the scientific literature on antibody immunity to coronaviruses, including SARS-CoV-2 as well as the related SARS-CoV-1, MERS-CoV and human endemic coronaviruses (HCoVs). We reviewed 1281 abstracts and identified 322 manuscripts relevant to 5 areas of focus: 1) antibody kinetics, 2) correlates of protection, 3) immunopathogenesis, 4) antigenic diversity and cross-reactivity, and 5) population seroprevalence. While studies of SARS-CoV-2 are necessary to determine immune responses to it, evidence from other coronaviruses can provide clues and guide future research.

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Section: Infection With Endemic Hcovs Produces Little Cross-reactivitmentioning

confidence: 99%

A systematic review of antibody mediated immunity to coronaviruses: antibody kinetics, correlates of protection, and association of antibody responses with severity of disease

Huang

García‐Carreras

Hitchings

et al. 2020

Preprint

310

383

View full text Add to dashboard Cite

show abstract

“…The arguments so far is that early childhood vaccinations might be protective, which is the opposite of our observation. Prior preclinical research (16) that was done during one of the previous coronavirus crisis shows clearly that childhood vaccinations are unlikely to drive different outcomes of COVID19 infections. This is further enhanced by the data presented in this study.…”

Section: Discussionmentioning

confidence: 99%

Association Between BCG Policy is Significantly Confounded by Age and is Unlikely to Alter Infection or Mortality Rates

Kirov

2020

Preprint

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Recently a number of publications looked at the association between COVID-19 morbidity and mortality on one hand and countries' policies with respect to BCG vaccination on the other. This connection arises from differences in the rates of infection in countries where BCG vaccination is mandatory compared to countries where mandatory vaccination no longer exists or was never implemented in the first place. In at least 2 preprint publications the authors expressed the view that the "known immunological benefits" of BCG vaccination may be behind the biological mechanism of such observation. One study accounted for different income levels in different groups. Another study did not attempted to do so, instead exploring the differences between countries where a booster shot is given vs others where no such practice exists (finding no connection). Both of these studies did not explore other potential confounding factors. Meanwhile the press has focused on these headlines and pushed the narrative that BCG vaccination is causally linked to infection and mortality rates. This poses a serious challenge, demonstrated by the recently initiated clinical trials on BCG vaccination within the COVID19 context. This study shows that population age is a very significant confounding factor that explains the rates of infections much better and has a solid biology mechanism which explains this correlation. It suggests that BCG vaccination may have little or no causal link to infection rates and advises that any follow up studies should control for several confounding factors, such as population age, ethnicity, rates of certain chronic diseases, time from community spread start date, major public policy decisions and income levels.

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“…Recent data on the Covid-19 outbreak report a very low incidence of confirmed cases in children as well as milder clinical pictures when compared to adults and elderly. 3,4 To our knowledge, at present, there is still neither available a specific vaccine nor drugs for the Covid-19 infection, and current treatments are mainly based on therapy for symptoms.…”

Section: Dear Editormentioning

confidence: 99%