Abstract:Background. New coronaviral infection (COVID-19) in most cases has less severe course in children than in adults. However, there were reports from the number of European countries and from United States (from March 2020) about children with new disease with signs of Kawasaki disease (KD) and toxic shock syndrome (TSS). So it has received one of the names children’s multisystem inflammatory syndrome (CMIS) associated with COVID-19. The aim of the study is to summarize up-to-date information about this disease.M… Show more
“…2 children with a severe course of the disease developed PMIS, which required transfer to the ICU. Our data are consistent with the literature, which shows that the moderate course of pneumonia without respiratory failure is approximately 40%, the frequency of severe course is 2.5-7.6%, and extremely severe is less than 1% [7]. According to the results of a systematic review including 1065 patients under the age of 19 years, this infection occurs in children mainly with mild respiratory and general symptoms or asymptomatic [7,10].…”
Section: Results and Its Discussionsupporting
confidence: 91%
“…They had signs of toxic shock syndrome, myocarditis with cardiogenic shock, called "pediatric multisystem inflammatory syndrome (PMIS)" [6]. Children developed fever (>38.5°C), cardiogenic shock or acute left ventricular (LV) dysfunction, LV ejection fraction <50%), C-reactive protein (CRP) content >100 mg/ml [7]. As given in the article, 17% of children had overweight and 9% had bronchial asthma among concomitant diseases.…”
Section: Introductionmentioning
confidence: 99%
“…The pathogenesis and pathoanatomical picture of COVID-19 is characterized by the development of generalized microangiopathy, manifested by the development of destructive-productive viral vasculitis and hypercoagulable syndrome. In the future, secondary lesions of the skin, internal organs, central nervous system and hemophagocytosis develop [7,10,11]. In this regard, in May 2020, recommendations were developed for the diagnosis and management of patients with PMIS [6,7].…”
Section: Introductionmentioning
confidence: 99%
“…In the future, secondary lesions of the skin, internal organs, central nervous system and hemophagocytosis develop [7,10,11]. In this regard, in May 2020, recommendations were developed for the diagnosis and management of patients with PMIS [6,7]. According to the authors, therapy depends on the clinical manifestations and severity of the disease.…”
The article discusses the state of the cardiovascular system in children who have had COVID-19, depending on the severity of the course of the infectious process. We conducted a retrospective analysis of the case histories of 88 children of various ages who were hospitalized with a confirmed diagnosis of a new coronavirus infection COVID-19 in September-November 2020.There were 48 boys (54.6%), girls - 40 (45.4%). According to the classification, the examined children were divided into 4 groups: pre-preschool period (1-3 years) - 9 (10.2%), pre-school period (from 3 to 7 years) - 32 (36.4%), junior school period ( 7-11 years old) - 29 (32.9%) and senior school period (from 12 to 16 years old) - 18 (20.4%) . An analysis of the characteristics of the course of COVID-19 depending on the severity showed that the moderate and severe course of the disease mostly developed in boys (58.5 and 60.0%), the mild course was typical for girls (66.7%).
“…2 children with a severe course of the disease developed PMIS, which required transfer to the ICU. Our data are consistent with the literature, which shows that the moderate course of pneumonia without respiratory failure is approximately 40%, the frequency of severe course is 2.5-7.6%, and extremely severe is less than 1% [7]. According to the results of a systematic review including 1065 patients under the age of 19 years, this infection occurs in children mainly with mild respiratory and general symptoms or asymptomatic [7,10].…”
Section: Results and Its Discussionsupporting
confidence: 91%
“…They had signs of toxic shock syndrome, myocarditis with cardiogenic shock, called "pediatric multisystem inflammatory syndrome (PMIS)" [6]. Children developed fever (>38.5°C), cardiogenic shock or acute left ventricular (LV) dysfunction, LV ejection fraction <50%), C-reactive protein (CRP) content >100 mg/ml [7]. As given in the article, 17% of children had overweight and 9% had bronchial asthma among concomitant diseases.…”
Section: Introductionmentioning
confidence: 99%
“…The pathogenesis and pathoanatomical picture of COVID-19 is characterized by the development of generalized microangiopathy, manifested by the development of destructive-productive viral vasculitis and hypercoagulable syndrome. In the future, secondary lesions of the skin, internal organs, central nervous system and hemophagocytosis develop [7,10,11]. In this regard, in May 2020, recommendations were developed for the diagnosis and management of patients with PMIS [6,7].…”
Section: Introductionmentioning
confidence: 99%
“…In the future, secondary lesions of the skin, internal organs, central nervous system and hemophagocytosis develop [7,10,11]. In this regard, in May 2020, recommendations were developed for the diagnosis and management of patients with PMIS [6,7]. According to the authors, therapy depends on the clinical manifestations and severity of the disease.…”
The article discusses the state of the cardiovascular system in children who have had COVID-19, depending on the severity of the course of the infectious process. We conducted a retrospective analysis of the case histories of 88 children of various ages who were hospitalized with a confirmed diagnosis of a new coronavirus infection COVID-19 in September-November 2020.There were 48 boys (54.6%), girls - 40 (45.4%). According to the classification, the examined children were divided into 4 groups: pre-preschool period (1-3 years) - 9 (10.2%), pre-school period (from 3 to 7 years) - 32 (36.4%), junior school period ( 7-11 years old) - 29 (32.9%) and senior school period (from 12 to 16 years old) - 18 (20.4%) . An analysis of the characteristics of the course of COVID-19 depending on the severity showed that the moderate and severe course of the disease mostly developed in boys (58.5 and 60.0%), the mild course was typical for girls (66.7%).
“…Некоторое различие клинической картины новой коронавирусной инфекции отмечается и в детском возрасте, которое связано, с одной стороны, с анатомо-физиологическими особенностями у детей, с другой -c отсутствием длительного воздействия вредных факторов (например, никотина) и тяжелых хронических заболеваний. В последнее время дискутируется вопрос о меньшей экспрессии ACE2 рецепторов у детей по сравнению с взрослыми людьми [9]. Таким образом, изучение особенностей коронавирусной инфекции в зависимости от возраста представляет интерес для практического здравоохранения.…”
The study of the infection caused by the SARS-CoV-2 coronavirus is highly relevant. Objective: To study the clinical and epidemiological features of a new coronavirus infection in children in the city of Omsk and the Omsk region during the 2020 epidemic. Materials and methods. We conducted a retrospective study of 68 children aged 1—18 years diagnosed with new coronavirus disease and receiving medical treatment in Infectious Diseases Hospital of City Children's Clinical Hospital № in Omsk between April and September 2020. In all children, the diagnosis was confirmed by examination of nasopharyngeal / oropharyngeal swabs for RNA SARS-CoV-2 by PCR. Results. Among those hospitalized prevailed children over 10 years old (61.7%), no reliable difference based on sex was observed. 83.8% of children contacted with COVID-19-infected people. Most children had the new coronavirus infection in mild form (61.8%) with upper respiratory tract damage. Pneumonia was recorded only in 16.2% of examined children over the age of 10. The key clinical symptoms in childhood were: yawn hyperemia, fever and cough. Impaired sense of smell in the form of hyposmia and anosmia developed only in children over the age of 10. Leukopenia detection in blood in moderate forms correlated with the presence of pneumonia. Conclusion. Given the mild course of COVID-19 in children, early isolation and treatment on an outpatient basis should be considered the most effective approach to patient management.
The novel coronavirus infection (COVID-19) is currently a widespread disease in all countries of the world. The adult population is predominantly involved in the epidemic process. In children, the disease proceeds, as a rule, in asymptomatic, mild and moderate forms. However, severe forms of the disease with the development of adverse outcomes are possible. Severe forms of infection are more likely to develop in children under the age of 1 year and older than 12 years. The risk group for a non-smooth course and adverse outcomes are children with concomitant diseases: genetic, neurological, metabolic disorders, congenital heart defects, obesity, diabetes mellitus, bronchial asthma and other chronic lung diseases, sickle cell anemia, oncopathology, immunodeficiency states. At present, various types of vaccines are used for specific prevention in the world: based on M-RNA technologies, vectorial, inactivated. These vaccines are effective and safe in reducing the burden of disease in eligible adolescents. Despite the emergence of new strains of circulating viruses, vaccines continue to be effective in preventing severe infections, hospitalization and death.
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