Children’s exposures to boron and biocides from slime products in Asian regions

Lim, Miyoung; Guak, Sooyoung; Cheong, Nam Yong; Song, Yoon Chae; Ho, Kin Fai; Nakai, S.; Lung, Shih-Chun Candice; Tantrakarnapa, Kraichat; Lee, Kiyoung

doi:10.1038/s41370-021-00321-9

Cited by 8 publications

(6 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Concentrations of isothiazolinones and parabens observed in this study and in the previous reports 5–7 are listed in Table 1. According to Japanese cosmetic regulations, 8 the upper limit for MI alone is 100 μg/g for products not intended for use on mucous membranes whereas that for MCI/MI mixture is 15 μg/g for rinse‐off products.…”

Section: Discussionsupporting

confidence: 64%

“…3 Although it is necessary to clarify the concentration of preservatives to examine the risk of contact dermatitis due to slime, a few reports have investigated the concentrations of these preservatives in slimes. 1,2,[5][6][7] To our knowledge, there is only one report on slime in Japan. 7 Therefore, herein, we investigated the concentrations of these preservatives in slimes.…”

mentioning

confidence: 99%

“…1,2,[5][6][7] To our knowledge, there is only one report on slime in Japan. 7 Therefore, herein, we investigated the concentrations of these preservatives in slimes.…”

mentioning

confidence: 99%

“…Recently, many instances of contact dermatitis induced by these “slime” toys have been reported, 1–4 and most cases have reportedly been caused by isothiazolinone preservatives, 1,2 with one case reported to be caused by a paraben preservative 3 . Although it is necessary to clarify the concentration of preservatives to examine the risk of contact dermatitis due to slime, a few reports have investigated the concentrations of these preservatives in slimes 1,2,5–7 . To our knowledge, there is only one report on slime in Japan 7 .…”

mentioning

confidence: 99%

See 3 more Smart Citations

Analysis of isothiazolinone and paraben preservatives in children's toy slime in Japan

2022

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 64%

mentioning

confidence: 99%

“…1,2,[5][6][7] To our knowledge, there is only one report on slime in Japan. 7 Therefore, herein, we investigated the concentrations of these preservatives in slimes.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Analysis of isothiazolinone and paraben preservatives in children's toy slime in Japan

2022

View full text Add to dashboard Cite

“…Nowadays, homemade recipes for slime preparation might contain various toxic, irritating, or allergenic compounds such as borax, boric acid, glues, creams, and various dyes. 9 In general, reactions to such compounds are local rather than systemic and these chemical compounds interact with the body through direct contact with hands, mouth, eyes, and nose. 10 Despite the potential toxic effects of homemade slime, playing with it can be beneficial for child development.…”

Section: Introductionmentioning

confidence: 99%

Effects of slime toy poisoning in children and teenagers

Oliveira

Bezerra

Loiola

et al. 2023

Rev. paul. pediatr.

View full text Add to dashboard Cite

Objective: The aim of this study was to identify which types of skin reactions are associated with slime toys and which of their ingredients are most frequently involved in cases of poisoning. Data source: Between January and July 2021, articles were selected using PubMed, SciELO, and LILACS databases. The following descriptors were used: (dermatitis OR rash OR eczema OR inflammation) AND slime. Inclusion criteria were articles available in full, in either Portuguese, English, or Spanish, published between January 2000 and July 31, 2021, and articles reporting cases of contact dermatitis or eczema potentially or directly attributed to slime toys. Articles not meeting these criteria and duplicate texts in the databases were excluded. Data synthesis: In total, 65 publications were identified, of which 16 were included in this review. This resulted in a total of 22 children (2 males, 20 females), aged between 4 and 13 years, who were reportedly intoxicated by slime toys, most of these being linked to homemade preparations. Studies reported the occurrence of contact or allergic dermatitis on hands, fingers, nails, forearms, and cheeks. The most allergenic and/or irritant ingredients included liquid detergent and soap. Additionally, patch tests identified positive reactions to methylisothiazolinone and methylchloroisothiazolinone, the preservatives used by chemical industries on preparation of glue, soap, detergents, etc. Conclusions: Although slime toys might be important for improving motor development and parental relationships, homemade slime toy recipes include several allergenic and irritant ingredients which might be exposed to vulnerable children and cause intoxications. Therefore, homemade slime toys preparations should be used cautiously and under the supervision of adults.

show abstract