Children conceived using ICSI do not have an increased risk of delayed mental development at 5 years of age

Leslie, Garth I.; Gibson, Frances; McMahon, Catherine; Cohen, Jerry D.; Dm, Saunders; Tennant, Christopher

doi:10.1093/humrep/deg408

Cited by 108 publications

(68 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our findings are reassuring and in line with the recent studies in young IVF children [2,4,7,8,10,11,14,[19][20][21][22][23][24][25] and at primary school age [12,17,18]. Olivennes et al [17] found, in a follow-up study of 422 IVF children aged 6 to 13 years, according to the French school system, that 92.2% of the children had at least average school achievement.…”

Section: Discussionsupporting

confidence: 90%

“…Developmental and neurological problems that were found at this young age were mainly related to prematurity, low birth weight, or multiple births [2,3,15]. Also, intellectual development around the age of 5 years was investigated and found not to be different in children conceived by IVF compared to naturally conceived children [4,11,19,20].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

School functioning in 8- to 18-year-old children born after in vitro fertilization

et al. 2008

View full text Add to dashboard Cite

The aim of this study was to examine the school functioning of 8-to 18-year-old children born after in vitro fertilization (IVF). We compared 233 children born after IVF to 233 matched control children born spontaneously from parents with fertility problems on measures of education level, general cognitive ability, school performance (need for extra help, repeating a grade, special education), and rates of learning and developmental disorders. No differences were found between IVF and control children on these measures of school functioning. More than 60% of adolescents at secondary school attended high academic levels (with access to high school or university). We conclude that children and adolescents born after IVF show good academic achievement and general cognitive ability. They do not experience any more educational limitations than the naturally conceived children and adolescents of the control group. The tendency of reassuring school functioning already found in younger IVF children has been shown to continue at secondary school age.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

School functioning in 8- to 18-year-old children born after in vitro fertilization

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Other studies have shown reassuring results at 1 year of age 5 and later. [28][29][30] Altogether, around 1100 children born after ICSI have been assessed at ages up to 5 years, and a similar intellectual development in children born after ICSI, after IVF, and conceived naturally was reported in most studies. However, some points in these studies have raised concern: Bonduelle et al observed a poorer performance in males born after ICSI; 29 and Ponjaert-Kristoffersen et al 31 reported that a higher proportion of 5-year-old children born after ICSI obtained scores below the cut-off on some visual-spatial subscales.…”

Section: Congenital Anomaliesmentioning

confidence: 69%

Increased frequency of severe major anomalies in children conceived by intracytoplasmic sperm injection

Sánchez-Albisua

Borell-Kost

Mau-Holzmann

et al. 2007

Develop Med Child Neuro

View full text Add to dashboard Cite

The neurodevelopmental outcome of children born after intracytoplasmic sperm injection (ICSI) is controversial. We compared the medical and developmental outcome of 34 singletons born after ICSI (20 males, 14 females; mean ages of 18mo and 40mo [SD 9mo]; range 2y 10mo–4y 8mo) with 39 case control studies (21 males, 18 females; mean ages of 18mo and 40mo [SD 4mo]; range 3y–4y 1mo). Each child was assessed physically and tested in three development domains (fine motor, gross motor, and language). Five children born after ICSI versus two control children (p=0.2) had major congenital anomalies (MaCAs). Four children born after ICSI versus no control children had severe MaCAs (p=0.04). These were defined as having a significant impact on development or causing chronic disease: Angelman syndrome (n=1), lissencephaly (n=1), Hanhart syndrome (n=1), and persistent hyperinsulinemic hypoglycaemia of infancy (n=1). Karyotyping in 23 children born after ICSI revealed no abnormalities. An imprinting defect was found in the child with Angelman syndrome. Results of developmental assessment were in all cases normal at the age of 18 months except for the three children with Angelman and Hanhart syndromes, and lissencephaly. At the second assessment, five more children born after ICSI and four control children showed abnormalities in one or more developmental domains. We conclude that there seems to be a higher frequency of severe major anomalies in children born after ICSI. An increased risk for imprinting defects cannot be excluded. If we exclude children with severe MaCAs, the incidence of an abnormal somatic or neurodevelopmental outcome in the fourth year of life in children born after ICSI is similar to that of spontaneously conceived children.

show abstract

“…Two prospective analyses of small numbers of IVF/ICSI children at early age (1-2 years or higher) did not identify a higher likelihood of developmental delay. [43][44][45][46][47][48] Similarly, Bonduelle and colleagues (2003) found no difference in the likelihood of developmental delay in IVF and IVF/ICSI children compared with natural conceptions. 49 A statistically significant trend towards higher IQ and verbal performance in IVF/ICSI children when compared to controls was observed.…”

Section: Developmental Delay and Neurological Impairment Concerns Formentioning

confidence: 99%

Intracytoplasmic Sperm Injection (ICSI) – What are the Risks?

Alukal

Lamb

2008

Urologic Clinics of North America

View full text Add to dashboard Cite

In vitro fertilization (IVF) used in combination with intracytoplasmic sperm injection (IVF/ICSI) allows otherwise sterile couples to become parents. Despite the fact that the oldest IVF conceived baby 1 is now over 30 years of age, questions about the safety of assisted reproductive technologies persist. The long term follow-up of the first generation of IVF/ICSI offspring offers a clearer picture of the safety of these technologies; despite these recent studies, however, there is still only an incomplete picture of the risks associated with the usage of these assisted reproductive techniques (ART) to offspring. The risk of multiple gestation continues to be of major concern because of its association with low birth weight, preterm delivery and increased perinatal mortality. Other ART outcomes typically assessed include: 1) congenital abnormality 2) developmental delay or abnormality 3) hormonal dysfunction 4) epigenetic effect. Existing maternal or paternal factors may confound any analysis of ART and spontaneous conception cohorts making it difficult to draw firm conclusions. This review outlines the risks associated with IVF/ICSI as a well defined treatment for couples with severe male factor infertility. Importantly, no discussion of the risks associated with IVF/ICSI can be conducted outside of the context of the existing IVF safety data. As such, both the safety of IVF and IVF/ICSI are considered here. Overall, the total body of data points to the conclusion that ICSI conceived children are at a higher absolute risk of the following conditions: 1) multiple gestation and its associated sequelae, 2) congenital defects (in particular genitourinary defects), and 3) epigenetic syndromes (such as Beckwith Wiedemann). Nevertheless, the absolute incidence of these events remains rare.

show abstract

Children conceived using ICSI do not have an increased risk of delayed mental development at 5 years of age

Abstract: These findings suggest that the genetic influence of parental cognitive ability is more important than the mode of conception in determining the long-term intellectual ability of children conceived using ICSI.

Cited by 108 publications

References 20 publications

School functioning in 8- to 18-year-old children born after in vitro fertilization

School functioning in 8- to 18-year-old children born after in vitro fertilization

Increased frequency of severe major anomalies in children conceived by intracytoplasmic sperm injection

Intracytoplasmic Sperm Injection (ICSI) – What are the Risks?

Contact Info

Product

Resources

About