Children and adults with acute lymphoblastic leukaemia have similar gene expression profiles

Abstract

In spite of the difference in clinical outcome, the gene expression pattern in children and adults with ALL is very similar and is primarily dependent on immunophenotype and cytogenetic aberrations. However, when age groups are compared, the expression patterns of infants and adults over 40 show a remarkable similarity.

Clinical and cytogenetic features of pediatric dic(9;20)(p13.2;q11.2)‐positive B‐cell precursor acute lymphoblastic leukemias: A nordic series of 24 cases and review of the literature

“…This type of information has been reported for only 14 patients in the literature (Slater et al, 1995;Heerema et al, 1996;Kuchinskaya et al, 2005), of which three had CNS involvement and one had a mediastinal mass. Thus, CNS involvement has been reported in 4/38 (11%) and a mediastinal mass in 2/38 (5%) cases.…”

“…FISH for CDKN2A revealed homozygous loss of this gene in one of the Nordic ALL [previously reported in Schoumans et al (2006) as case 7]; the remaining nine tested cases had, as expected, hemizygous deletions. Eight of the 49 previously reported cases had been analyzed by FISH for CDKN2A alterations (Andreasson et al, 2000;Kuchinskaya et al, 2005, Van Zutven et al, 2005, Strefford et al, 2007, and five of these had homozygous deletions. Thus, 6 (33%) of 18 dic(9;20)-positive ALL tested displayed homozygous loss of this gene (Table 1).…”

“…Data on risk stratification have been given for 15 previously reported cases (Slater et al, 1995;Heerema et al, 1996Heerema et al, , 2000Kuchinskaya et al, 2005), of which only 3 were standard risk. Thus, 31/39 (79%) cases were nonstandard risk.…”

What determines the outcomes for adolescents and young adults with acute lymphoblastic leukemia treated on cooperative group protocols? A comparison of Children's Cancer Group and Cancer and Leukemia Group B studies

“…While we cannot exclude the possibility that discrete biologic differences in the pathogenetic mechanisms of ALL occur that may influence drug responsiveness as patients age from 16 to 20 years old, this seems quite unlikely, and these age-specific differences in outcome were only seen in CALGB, and not in CCG patients. 30 How might disparities in the practice patterns of pediatric and adult hematologists/oncologists and the attitudes of AYA patients who they treat contribute to these different outcomes? This topic has been discussed heatedly, both at recent hematology meetings and in the literature, 31 yet the question remains largely unanswered with little data available.…”

Combined high-resolution array-based comparative genomic hybridization and expression profiling of ETV6/RUNX1-positive acute lymphoblastic leukemias reveal a high incidence of cryptic Xq duplications and identify several putative target genes within the commonly gained region

“…14 To the best of our knowledge, only eight ETV6/RUNX1-positive ALLs with partial Xq gains, as identified by metaphase CGH or multicolor FISH, have been described. [15][16][17][27][28][29] All the gains in these cases were generated through unbalanced translocations involving Xq, none of which were seen by conventional cytogenetics. Notably, all cases with Xq gain in the present study were males, as were six of the previously published cases; 16,17,[27][28][29] the gender of the remaining two cases was not reported.…”