2008
DOI: 10.1182/blood-2008-01-130237
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What determines the outcomes for adolescents and young adults with acute lymphoblastic leukemia treated on cooperative group protocols? A comparison of Children's Cancer Group and Cancer and Leukemia Group B studies

Abstract: We performed a retrospective comparison of presenting features, planned treatment, complete remission (CR) rate, and outcome of 321 adolescents and young adults (AYAs) ages 16 to 20 years with newly diagnosed acute lymphoblastic leukemia (ALL) who were treated on consecutive trials in either the Children's Cancer Group (CCG) or the Cancer and Leukemia Group B (CALGB) from 1988 to 2001. CR rates were identical, 90% for both CALGB and CCG AYAs. CCG AYAs had a 63% event-free survival (EFS) and 67% overall surviva… Show more

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Cited by 481 publications
(358 citation statements)
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“…[3][4][5][6] However, the effect of therapeutic intensification in older adults has not been extensively studied, and this population is often excluded from clinical trials or transplantation studies. We now demonstrate that an intensified multi-agent approach can lead to promising results in older adults.…”
Section: Discussionmentioning
confidence: 99%
“…[3][4][5][6] However, the effect of therapeutic intensification in older adults has not been extensively studied, and this population is often excluded from clinical trials or transplantation studies. We now demonstrate that an intensified multi-agent approach can lead to promising results in older adults.…”
Section: Discussionmentioning
confidence: 99%
“…La mayor tasa de recaídas puede deberse a una menor adherencia de los pacientes con el equipo de hemato-oncólogos de adulto, así como a la postergación o reducción de dosis de quimioterapia en un intento por reducir la toxicidad, como se observa en diversas publicaciones internacionales [6][7][8][9][10][11] . …”
Section: Discussionunclassified
“…6 Hematóloga Panda Hospital san Juan de dios. 7 Hematólogo Panda Hospital sótero del río. 8 Hematólogo Panda Hospital Barros luco trudeau.…”
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