Childhood trauma, PTSD, and problematic alcohol and substance use in low-income, African-American men and women

Cross, Dorthie; Crow, Thomas; Powers, Abigail; Bradley, Bekh

doi:10.1016/j.chiabu.2015.01.007

Cited by 66 publications

(45 citation statements)

References 95 publications

(110 reference statements)

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“…The majority of cross-sectional or retrospective studies examining PTSD-alcohol misuse in women largely support the premise that there are significant associations between the severity of PTSD symptoms and alcohol misuse. This finding was documented in a variety of populations, including female Veterans (Dobie et al, 2004;Lehavot, Browne, et al, 2014;Nunnink et al, 2010;Ouimette, Wolfe, & Chrestman, 1996;Scott et al, 2013), treatment-seeking substance users (Heffner et al, 2011;Sonne, Back, Zuniga, Randall, & Brady, 2003), non-treatment-seeking substance users (Johnson, Striley, & Cottler, 2006;Stewart, Conrod, Pihl, & Dongier, 1999), and college and community samples (Acierno, Resnick, Kilpatrick, Saunders, & Best, 1999;Bedard-Gilligan, Cronce, Lehavot, Blayney, & Kaysen, 2014;Cross, Crow, Powers, & Bradley, 2015;Epstein, Saunders, Kilpatrick, & Resnick, 1998;Jaquier, Flanagan, & Sullivan, 2015;Kachadourian, Pilver, & Potenza, 2014;Kessler et al, 1995;Sartor et al, 2010;Stappenbeck, Bedard-Gilligan, Lee, & Kaysen, 2013;Sullivan, Ashare, Jaquier, & Tennen, 2012;Timko et al, 2008;Ullman et al, 2009;Watt et al, 2012).…”

Section: The Nature Of Ptsd-alcohol Misuse In Womenmentioning

confidence: 84%

“…This finding was documented in a variety of populations, including female Veterans (Dobie et al, 2004;Lehavot, Browne, et al, 2014;Nunnink et al, 2010;Ouimette, Wolfe, & Chrestman, 1996;Scott et al, 2013), treatment-seeking substance users (Heffner et al, 2011;Sonne, Back, Zuniga, Randall, & Brady, 2003), non-treatment-seeking substance users (Johnson, Striley, & Cottler, 2006;Stewart, Conrod, Pihl, & Dongier, 1999), and college and community samples (Acierno, Resnick, Kilpatrick, Saunders, & Best, 1999;Bedard-Gilligan, Cronce, Lehavot, Blayney, & Kaysen, 2014;Cross, Crow, Powers, & Bradley, 2015;Epstein, Saunders, Kilpatrick, & Resnick, 1998;Jaquier, Flanagan, & Sullivan, 2015;Kachadourian, Pilver, & Potenza, 2014;Kessler et al, 1995;Sartor et al, 2010;Stappenbeck, Bedard-Gilligan, Lee, & Kaysen, 2013;Sullivan, Ashare, Jaquier, & Tennen, 2012;Timko et al, 2008;Ullman et al, 2009;Watt et al, 2012). This finding was documented in a variety of populations, including female Veterans (Dobie et al, 2004;Lehavot, Browne, et al, 2014;Nunnink et al, 2010;Ouimette, Wolfe, & Chrestman, 1996;Scott et al, 2013), treatment-seeking substance users (Heffner et al, 2011;Sonne, Back, Zuniga, Randall, & Brady, 2003), non-treatment-seeking substance users (Johnson, Striley, & Cottler, 2006;Stewart, Conrod, Pihl, & Dongier, 1999)...…”

Section: The Nature Of Ptsd-alcohol Misuse In Womenmentioning

confidence: 94%

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Sexual Traumatic Event Exposure, Posttraumatic Stress Symptomatology, and Alcohol Misuse Among Women: A Critical Review of the Empirical Literature

Langdon

Rubin

Brief

et al. 2016

Clin Psychol Sci Pract

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The current review summarizes and critically evaluates the existing literature to shed light on two key questions: (a) the impact of trauma exposure on alcohol use (and vice versa; the impact of alcohol use on risk for trauma exposure) in women, and (b) the nature of PTSD-alcohol misuse comorbidity in women. The secondary aim was to explore moderators or mechanisms of action. Findings suggest that sexual trauma may be especially relevant to alcohol misuse in women. Crosssectional data generally support PTSD-alcohol misuse associations; however, findings from prospective studies are mixed. Significantly less is known about moderators/mediators of these relations, with the majority of work focused on emotional and motivational processes. Limitations, future directions, and clinical implications are discussed.

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Section: The Nature Of Ptsd-alcohol Misuse In Womenmentioning

confidence: 84%

Section: The Nature Of Ptsd-alcohol Misuse In Womenmentioning

confidence: 94%

Sexual Traumatic Event Exposure, Posttraumatic Stress Symptomatology, and Alcohol Misuse Among Women: A Critical Review of the Empirical Literature

Langdon

Rubin

Brief

et al. 2016

Clin Psychol Sci Pract

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“…Both groups reported very low levels of alcohol and drug abuse, particularly relative to other traumatized samples. [51,52]…”

Section: Group Characteristicsmentioning

confidence: 99%

Childhood Maltreatment Predicts Reduced Inhibition-Related Activity in the Rostral Anterior Cingulate in Ptsd, but Not Trauma-Exposed Controls

et al. 2016

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Background A deficit in the ability to inhibit fear has been proposed as a biomarker of post-traumatic stress disorder (PTSD). Previous research indicates that individuals with PTSD show reduced inhibition-related activation in rostral anterior cingulate cortex (rACC). The goal of the current study was to investigate differential influences of an early environmental risk factor for PTSD – childhood maltreatment – on inhibition-related brain function in individuals with PTSD versus trauma-exposed controls. Methods Individuals with PTSD (n=37) and trauma-exposed controls (n=53) were recruited from the primary care waiting rooms of an urban public hospital in Atlanta, GA. Participants completed an inhibition task during fMRI, and reported childhood and adult traumatic experiences. The groups were matched for adult and child trauma load. Results We observed an interaction between childhood maltreatment severity and PTSD status in the rACC (p<.05, corrected), such that maltreatment was negatively associated with inhibition-related rACC activation in the PTSD group, but did not influence rACC activation in the TC group. Rostral ACC activation was associated with inhibition-related task performance in the TC group but not the PTSD group, suggesting a possible contribution to stress resilience. Conclusions Findings highlight individual differences in neural function following childhood trauma, and point to inhibition-related activation in rostral ACC as a risk factor for PTSD.

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“…First, the majority of the studies that examine the associations between childhood and adolescent adversity and substance use disorder or health outcomes are limited by cross-sectional designs. Most studies either lack dating of onset of substance use disorder or health outcomes to ensure temporal precedence of the adverse events or include periods in which the adverse events and outcomes of interest overlap temporally (e.g., Cross et al 2015; Goodwin and Stein 2004; Grella et al 2005; Khoury et al 2010; Springer et al 2007; Triffleman et al 1995). Prospective studies are needed to strengthen our understanding of the risks conferred by childhood and adolescent adversity.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Childhood and Adolescent Adversity on Substance Use Disorders and Poor Health in Early Adulthood

Wolitzky-Taylor

Sewart

Vrshek‐Schallhorn

et al. 2016

J Youth Adolescence

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Childhood and adolescent adversity have been shown to predict later mental and physical health outcomes. Understanding which aspects and developmental timings of adversity are important, and the mechanisms by which they have their impact may help guide intervention approaches. A large subset of adolescents (N = 457; Female 68.9%) from the 10-year longitudinal Youth Emotion Project was examined to better understand the associations among childhood/adolescent adversity, substance use disorder, and later health quality. Adolescent (but not childhood) adversities were associated with poorer health in late adolescence/early adulthood, adolescent adversities were associated with subsequent onset of substance use disorder, and adolescent adversities continued to be associated with poorer health in late adolescence/early adulthood after accounting for the variance explained by substance use disorder onset. These associations were observed after statistically accounting for emotional disorders and socioeconomic status. Specific domains of adversity uniquely predicted substance use disorder and poorer health outcomes. In contrast with current recent research, our findings suggest the association between childhood/adolescent adversity and poorer health outcomes in late adolescence and emerging adulthood are not entirely accounted for by substance use disorder, suggesting efforts to curtail family-based adolescent adversity may have downstream health benefits.

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Childhood trauma, PTSD, and problematic alcohol and substance use in low-income, African-American men and women

Cited by 66 publications

References 95 publications

Sexual Traumatic Event Exposure, Posttraumatic Stress Symptomatology, and Alcohol Misuse Among Women: A Critical Review of the Empirical Literature

Sexual Traumatic Event Exposure, Posttraumatic Stress Symptomatology, and Alcohol Misuse Among Women: A Critical Review of the Empirical Literature

Childhood Maltreatment Predicts Reduced Inhibition-Related Activity in the Rostral Anterior Cingulate in Ptsd, but Not Trauma-Exposed Controls

The Effects of Childhood and Adolescent Adversity on Substance Use Disorders and Poor Health in Early Adulthood

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