Childhood trauma and suicide attempt: A meta-analysis of longitudinal studies from the last decade

Zatti, Cleonice; Rosa, Virgínia de Oliveira; Barros, Alcina Juliana Soares; Valdivia, Lucianne Jobim; Calegaro, Vítor Crestani; Freitas, Lúcia Helena Machado; Ceresér, Keila Maria Mendes; Rocha, Neusa Sica da; Bastos, André Goettems; Schuch, Felipe Barreto

doi:10.1016/j.psychres.2017.06.082

Cited by 202 publications

(166 citation statements)

References 23 publications

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“…Especially an increased risk for mental disorders (e.g., depression, post-traumatic stress disorder, schizophrenia) and their unfavorable outcomes after ELS/CT experience has been repeatedly reported in several retrospective (5,(22)(23)(24)(25) but also prospective studies (26)(27)(28)(29). Similarly, history of ELS/CT has been associated with risk behavior patterns, such as substance abuse and suicide attempts in later life (30)(31)(32)(33)(34)(35). Furthermore, several larger-scale studies and meta-analyses also suggest a close association of ELS/CT with adverse physical health and in particular with cardiovascular, gastrointestinal, neuromusculoskeletal, pulmonary, inflammatory, and metabolic diseases, chronic pain syndromes, frequency of medical consultations, as well as number of medical diagnoses (24,(36)(37)(38)(39)(40)(41)(42).…”

Section: Introductionmentioning

confidence: 95%

Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation

et al. 2019

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Early life stressors display a high universal prevalence and constitute a major public health problem. Prolonged psychoneurobiological alterations as sequelae of early life stress (ELS) could represent a developmental risk factor and mediate risk for disease, leading to higher physical and mental morbidity rates in later life. ELS could exert a programming effect on sensitive neuronal brain networks related to the stress response during critical periods of development and thus lead to enduring hyper- or hypo-activation of the stress system and altered glucocorticoid signaling. In addition, alterations in emotional and autonomic reactivity, circadian rhythm disruption, functional and structural changes in the brain, as well as immune and metabolic dysregulation have been lately identified as important risk factors for a chronically impaired homeostatic balance after ELS. Furthermore, human genetic background and epigenetic modifications through stress-related gene expression could interact with these alterations and explain inter-individual variation in vulnerability or resilience to stress. This narrative review presents relevant evidence from mainly human research on the ten most acknowledged neurobiological allostatic pathways exerting enduring adverse effects of ELS even decades later (hypothalamic-pituitary-adrenal axis, autonomic nervous system, immune system and inflammation, oxidative stress, cardiovascular system, gut microbiome, sleep and circadian system, genetics, epigenetics, structural, and functional brain correlates). Although most findings back a causal relation between ELS and psychobiological maladjustment in later life, the precise developmental trajectories and their temporal coincidence has not been elucidated as yet. Future studies should prospectively investigate putative mediators and their temporal sequence, while considering the potentially delayed time-frame for their phenotypical expression. Better screening strategies for ELS are needed for a better individual prevention and treatment.

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Section: Introductionmentioning

confidence: 95%

Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation

et al. 2019

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“…1,2 Suicide is an ancient and cross-cultural theme and remains a public health problem worldwide. 3 One recent meta-analysis by Zatti et al 4 identified childhood trauma as a modifiable risk factor for lifetime suicide attempts. In that study, sexual and emotional abuse and physical neglect (considered psychological traumas) were associated with suicide attempt (SA).…”

Section: Introductionmentioning

confidence: 99%

The association between traumatic experiences and suicide attempt in patients treated at the Hospital de Pronto Socorro in Porto Alegre, Brazil

Zatti

Guimarães

Soibelman³

et al. 2020

Trends Psychiatry Psychother.

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Objective: To analyze associations between attempted suicide and childhood trauma. Methods: A seven month comparative case-control study (28 subjects-patients with suicide attempt; 56 controls-patients without suicide attempt). The following instruments were used: Childhood Trauma Questionnaire (CTQ), Mini International Neuropsychiatric Interview (MINI), and Medical Outcomes Study (MOS). Results: The group with suicide attempt had significantly higher scores for some variables: emotional abuse (p < 0.001), physical abuse (p < 0.001), emotional neglect (p < 0.001), and physical neglect (p < 0.001). Conclusions: The results suggest that variables related to previous trauma may influence future suicide attempts. The adoption of preventive and therapeutic actions related to mistreatments during child development is a crucial factor in reduction of suicide risk.

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“…Ruhsal hastalıklar, travmatik yaşam olayları ya da fiziksel sağlık problemleri gibi intihar riskini arttıran bir çok faktör tanımlanmıştır. Diğer faktörlerden bağımsız olarak çocukluğun erken dönemlerinde fiziksel ve cinsel istismara uğrama ve ihmal gibi travmatik yaşantıların intihar eğilimi ile ilişkili olduğu çeşitli çalışmalarda ortaya konmuştur (8).…”

Section: Introductionunclassified

“…Hastaların intihara yatkınlığını arttıran durumların saptanması olası intihar girişimlerinin önlenmesi açısından önemlidir. Genel populasyonda çocukluk çağı travmalarının intihar riskini arttırdığı bilinmektedir (8…”

Section: Introductionunclassified

Childhood traumas in patients with multiple sclerosis and its relationship with suicide probability (tur)

Işık-Ulusoy¹,

Horasanlı²

2019

J Clin Psy

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Childhood trauma and suicide attempt: A meta-analysis of longitudinal studies from the last decade

Cited by 202 publications

References 23 publications

Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation

Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation

The association between traumatic experiences and suicide attempt in patients treated at the Hospital de Pronto Socorro in Porto Alegre, Brazil

Childhood traumas in patients with multiple sclerosis and its relationship with suicide probability (tur)

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