Childhood sleep and adolescent chronic fatigue syndrome (CFS/ME): evidence of associations in a UK birth cohort

Collin, Simon M.; Norris, Tom; Gringras, Paul; Blair, Peter S; Tilling, Kate; Crawley, Esther

doi:10.1016/j.sleep.2018.01.005

Cited by 10 publications

(4 citation statements)

References 41 publications

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“…A recent birth cohort study found that participants who developed chronic disabling fatigue during adolescence had a shorter sleep duration during their early childhood. The authors suggested that sleep abnormalities may be a risk factor for the development of CFS/ME, and that this may be associated with dysfunction of an underlying physiological mechanism (Collin et al, 2018b). Sleep problems may also be associated with disruptions to circadian rhythms, although research on this is inconsistent and further higher quality research is needed (Snodgrass et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Psychological and demographic factors associated with fatigue and social adjustment in young people with severe chronic fatigue syndrome/myalgic encephalomyelitis: a preliminary mixed-methods study

et al. 2019

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This mixed-methods study investigated factors associated with fatigue, disability and school attendance in young people with severe CFS/ME. Participants' illness experiences were also explored. Questionnaires were completed at baseline (T1) and approximately 5 months later (T2). There were 51 participants aged between 12 and 25, with a mean age of 18.8 years (SD 3.4). At T1, participants reported severe fatigue and poor social adjustment. Stronger fear avoidance beliefs at T1 were associated with higher fatigue at T2, and with worse social adjustment at T1 and T2. Female gender was associated with lower work/school attendance at T1 and T2 but not with higher fatigue or worse social adjustment. Having accessed treatment was associated with reporting lower levels of work/school attendance at T1 and T2. Multivariate analyses of key outcomes identified significant associations between stronger fear avoidance beliefs and worse social adjustment at T2, and between female gender and lower work/school attendance at T2. It was clear from the qualitative data that severe CFS/ME negatively impacted on many aspects of young people's lives. Fearful beliefs about activity could be targeted using cognitive-behavioural interventions.

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Section: Discussionmentioning

confidence: 99%

Psychological and demographic factors associated with fatigue and social adjustment in young people with severe chronic fatigue syndrome/myalgic encephalomyelitis: a preliminary mixed-methods study

et al. 2019

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“…It is worth noting that previous follow-up studies have tended to identify demographic predictors (rather than health/psychological predictors) of future clinical status, namely: older age, female gender, higher IQ, higher BMI, and school absenteeism [12,15,24,76]. Those studies that have found associations between baseline health/psychological wellbeing-e.g., sleep quality [77], depression [28,78], anxiety and fatigue [32]-and follow-up recovery status have relied on a proxy for ME/CFS (e.g., "CFS-like symptoms", "Chronic Disabling Fatigue", etc.). Therefore, it remains to be seen whether baseline aspects of health and psychological wellbeing are useful prognostic indicators of future diagnostic status or recovery in adolescents who have been diagnosed by a paediatric ME/CFS specialist.…”

Section: Predictors Of Me/cfs Criteria Fulfilmentmentioning

confidence: 99%

Health, Wellbeing, and Prognosis of Australian Adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Case-Controlled Follow-Up Study

Josev

Cole

Scheinberg

et al. 2021

JCM

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Background: The purpose of this study was to follow-up an Australian cohort of adolescents newly-diagnosed with ME/CFS at a tertiary paediatric ME/CFS clinic and healthy controls over a mean period of two years (range 1–5 years) from diagnosis. Objectives were to (a) examine changes over time in health and psychological wellbeing, (b) track ME/CFS symptomatology and fulfillment of paediatric ME/CFS diagnostic criteria over time, and (c) determine baseline predictors of ME/CFS criteria fulfilment at follow-up. Methods: 34 participants aged 13–18 years (25 ME/CFS, 23 controls) completed standardised questionnaires at diagnosis (baseline) and follow-up assessing fatigue, sleep quality and hygiene, pain, anxiety, depression, and health-related quality of life. ME/CFS symptomatology and diagnostic criteria fulfilment was also recorded. Results: ME/CFS patients showed significant improvement in most health and psychological wellbeing domains over time, compared with controls who remained relatively stable. However, fatigue, pain, and health-related quality of life remained significantly poorer amongst ME/CFS patients compared with controls at follow-up. Sixty-five percent of ME/CFS patients at baseline continued to fulfil ME/CFS diagnostic criteria at follow-up, with pain the most frequently experienced symptom. Eighty-two percent of patients at follow-up self-reported that they still had ME/CFS, with 79% of these patients fulfilling criteria. No significant baseline predictors of ME/CFS criteria fulfilment at follow-up were observed, although pain experienced at baseline was significantly associated with criteria fulfilment at follow-up (R = 0.6, p = 0.02). Conclusions: The majority of Australian adolescents with ME/CFS continue to fulfil diagnostic criteria at follow-up, with fatigue, pain, and health-related quality of life representing domains particularly relevant to perpetuation of ME/CFS symptoms in the early years following diagnosis. This has direct clinical impact for treating clinicians in providing a more realistic prognosis and highlighting the need for intervention with young people with ME/CFS at the initial diagnosis and start of treatment.

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“…Some studies have found that anxiety and depression are associated with a higher risk of developing chronic fatigue over the course of 4 to 6 months (Rimes et al, 2007), although in the ALSPAC cohort, depressive symptoms at age 9 and 13 were not associated with chronic disabling fatigue at age 16 once co-morbid depressive symptoms were accounted for (Collin et al, 2019). In the same cohort low levels of physical activity (Collin et al, 2018a) and shorter night-time sleep duration and difficulties in going to sleep (Collin et al, 2018b) were found to be associated with subsequent chronic disabling fatigue.…”

Section: Changes In Epidemiologymentioning

confidence: 97%

Paediatric chronic fatigue syndrome: 25 year perspective

Loades

Crawley

Chalder

et al. 2020

Clin Child Psychol Psychiatry

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Over the lifetime of Clinical Child Psychology and Psychiatry, there has been considerable progress in understanding the epidemiology of Chronic Fatigue Syndrome (CFS), also known as myalgic encephalomyelitis (ME) and some progress in testing treatment approaches. Twenty-five years ago, clinicians and researchers did not believe that CFS existed in primary school children, little was known about the experience of children, and there were no randomised controlled trials testing treatment approaches. In this review, major developments in epidemiology, knowledge about clinical presentations and correlates, impact of CFS and treatment approaches will be highlighted. We are clinicians and researchers working in specialist CFS services in the United Kingdom.CFS has been a defined diagnostic entity since 1991 (Sharpe et al., 1991). There are several different diagnostic frameworks for diagnosing CFS (Carruthers et al., 2011;Fukuda et al., 1994;NICE, 2007;Sharpe et al., 1991). All include ongoing, debilitating fatigue which is not secondary to another medical condition or to exertion. Concomitant symptoms include general malaise, headaches, muscle and joint pain, nausea, disrupted sleep, dizziness and cognitive difficulties. Initially, the diagnostic criteria for adults were applied to children and young people. In 2004, the Royal College of Paediatrics and Child Health (RCPCH, 2004) recommended that fatigue lasting > 3 months was sufficient, a shorter duration than is required for adults. This has been reflected in some but not all the diagnostic frameworks. Here, we predominantly draw on evidence from clinical cohorts with a confirmed CFS diagnosis and evidence from general population studies of chronic debilitating fatigue, not necessarily formally assessed and diagnosed CFS. Changes in epidemiologyTwenty-five years ago, we did not know how common CFS was in teenagers, and whether it even existed in primary school aged children. The evidence base for the prevalence, incidence, and risk factors in paediatric CFS has since developed considerably.A recent systematic review and meta-analysis of prevalence studies found six studies in children and adolescents, with an estimated prevalence of 0.89% although there was considerable

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Childhood sleep and adolescent chronic fatigue syndrome (CFS/ME): evidence of associations in a UK birth cohort

Cited by 10 publications

References 41 publications

Psychological and demographic factors associated with fatigue and social adjustment in young people with severe chronic fatigue syndrome/myalgic encephalomyelitis: a preliminary mixed-methods study

Psychological and demographic factors associated with fatigue and social adjustment in young people with severe chronic fatigue syndrome/myalgic encephalomyelitis: a preliminary mixed-methods study

Health, Wellbeing, and Prognosis of Australian Adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Case-Controlled Follow-Up Study

Paediatric chronic fatigue syndrome: 25 year perspective

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