Childhood Overweight/Obesity and Asthma: Is There a Link? A Systematic Review of Recent Epidemiologic Evidence

Papoutsakis, Constantina; Priftis, Kostas Ν.; Drakouli, Maria; Prifti, Stamatina; Konstantaki, Eva; Chondronikola, Maria; Antonogeorgos, Georgios; Matziou, Vasiliki

doi:10.1016/j.jand.2012.08.025

Cited by 133 publications

(108 citation statements)

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“…It has been shown that inhaled steroids, a commonly prescribed medication for asthma, might have a positive dose effect on children's weight and therefore increased medication use would cause obesity, rather than the other way around (61) . It seems more plausible, however, that obesity precedes asthma or at least its manifestation, a hypothesis which is supported by growing evidence (62) .…”

Section: Possible Linksmentioning

confidence: 97%

“…Early-life exposures play a crucial role in the development of asthma and obesity. Some of the most important factors linking asthma with obesity are birth weight, both low and high (49) , and breast-feeding (62) . In addition, poor maternal diet, low in micronutrients such as vitamins D, E and C, and maternal weight gain during pregnancy were shown to increase the chances of the offspring having asthma and/or obesity later in life (91)(92)(93)(94)(95) .…”

Section: Possible Linksmentioning

confidence: 99%

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Association between obesity and asthma – epidemiology, pathophysiology and clinical profile

2016

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Obesity is a risk factor for asthma, and obese asthmatics have lower disease control and increased symptom severity. Several putative links have been proposed, including genetics, mechanical restriction of the chest and the intake of corticosteroids. The most consistent evidence, however, comes from studies of cytokines produced by the adipose tissue called adipokines. Adipokine imbalance is associated with both proinflammatory status and asthma. Although reverse causation has been proposed, it is now acknowledged that obesity precedes asthma symptoms. Nevertheless, prenatal origins of both conditions complicate the search for causality. There is a confirmed role of neuro-immune cross-talk mediating obesityinduced asthma, with leptin playing a key role in these processes. Obesity-induced asthma is now considered a distinct asthma phenotype. In fact, it is one of the most important determinants of asthma phenotypes. Two main subphenotypes have been distinguished. The first phenotype, which affects adult women, is characterised by later onset and is more likely to be non-atopic. The childhood obesity-induced asthma phenotype is characterised by primary and predominantly atopic asthma. In obesity-induced asthma, the immune responses are shifted towards T helper (Th) 1 polarisation rather than the typical atopic Th2 immunological profile. Moreover, obese asthmatics might respond differently to environmental triggers. The high cost of treatment of obesity-related asthma, and the burden it causes for the patients and their families call for urgent intervention. Phenotype-specific approaches seem to be crucial for the success of prevention and treatment.

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Section: Possible Linksmentioning

confidence: 97%

Section: Possible Linksmentioning

confidence: 99%

Association between obesity and asthma – epidemiology, pathophysiology and clinical profile

2016

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“…The prevalence of excess weight and obesity is continuously increasing, affecting millions of adults and children in developed and developing nations [1]. The excessive accumulation of body fat is linked with several health problems and metabolic disorders including insulin resistance, diabetes mellitus, dyslipidemia, and cardiovascular disorders [2].…”

Section: Introductionmentioning

confidence: 99%

Vitamins C, E, and NADH on <i>in Vitro</i> Lymphocyte Proliferation and Redox Status among Obese Patients

Meraou¹,

Merzouk²,

Saidi³

et al. 2016

FNS

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Background: The prevalence of overweight and obesity associated with oxidative stress and immune abnormalities is continuously increasing. Antioxidant supplementations might counteract potential damage caused by ROS to cellular tissues. Objective: To determine the role of vitamins on immune improvement during obesity, we investigated in vitro effects of vitamins C, E, and NADH on mitogen-stimulated proliferation, Th1-and Th2-type cytokine production, and oxidant/antioxidant status of lymphocytes isolated from obese patients. Methods: Peripheral blood lymphocytes were isolated using a density gradient of Histopaque. They were in vitro cultured and stimulated by Con A in the presence or absence of vitamins. Cell proliferation was determined by MTT assay and interleukin-2, interleukin-4 and interferon-γ (INFγ) secretions. Cell oxidant/antioxidant balance was studied by assaying glutathione (GSH), malondialdehyde (MDA), carbonyl protein levels, catalase activity and micronucli frequency. Results: Obesity is associated with enhanced oxidative stress response. Indeed, vitamin C, E and NADH improved significantly lymphocyte proliferation and diminished cellular oxidative stress. Conclusion: Treatments of lymphocytes with vitamins had beneficial effects on lymphocyte proliferation, cytokines secretions and redox status, generating an anti-inflammatory profile and should be considered in therapeutic approaches for normalizing immune cell function in obesity.

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“…Obesity is a common comorbidity to asthma and has been associated with not only the development of asthma but also less control of asthma symptoms and increased risk for hospitalization. 1 Recent prospective evidence supports the notion that increased body weight precedes asthma development, but there is ongoing debate as to whether obesity directly increases this risk or whether patients first experience asthma and then become overweight or obese, potentially because of respiratory constraints and reduced physical activity. 1,2 Despite a well-established association of obesity with asthma, gaps remain in our understanding of the factors contributing to this relationship.…”

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confidence: 99%

Obesity and asthma: The chicken or the egg?

Stukus

2015

Journal of Allergy and Clinical Immunology

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Childhood Overweight/Obesity and Asthma: Is There a Link? A Systematic Review of Recent Epidemiologic Evidence

Cited by 133 publications

References 123 publications

Association between obesity and asthma – epidemiology, pathophysiology and clinical profile

Association between obesity and asthma – epidemiology, pathophysiology and clinical profile

Vitamins C, E, and NADH on <i>in Vitro</i> Lymphocyte Proliferation and Redox Status among Obese Patients

Obesity and asthma: The chicken or the egg?

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Childhood Overweight/Obesity and Asthma: Is There a Link? A Systematic Review of Recent Epidemiologic Evidence

Cited by 133 publications

References 123 publications

Association between obesity and asthma – epidemiology, pathophysiology and clinical profile

Association between obesity and asthma – epidemiology, pathophysiology and clinical profile

Vitamins C, E, and NADH on &lt;i&gt;in Vitro&lt;/i&gt; Lymphocyte Proliferation and Redox Status among Obese Patients

Obesity and asthma: The chicken or the egg?

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Vitamins C, E, and NADH on <i>in Vitro</i> Lymphocyte Proliferation and Redox Status among Obese Patients