“…Comorbidities directly associated with excess body fat include T2DM, certain cancers and cardiovascular diseases including hypertension, coronary artery disease and stroke 9 . More severe cases of obesity are associated with an increased incidence of sleep apnea 10,11 , asthma [12][13][14] , gallstones 15 , steatohepatitis 16 , glomerulosclerosis 17 , dyslipidaemia and endothelial dysfunction 18,19 . The metabolic complications linked to obesity are often attributed to systemic processes such as metabolic inflammation or cellular pathologies such as mitochondrial dysfunction 20 and/or stress of the endoplasmic reticulum due to lipotoxicity 19,21 .…”