Childhood Nephrotic Syndrome in Ilorin

Adedoyin, OT; Gbelee, Hod

doi:10.4314/njp.v28i3.12060

Cited by 11 publications

(31 citation statements)

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“…As expected, progression to CKD and mortality were predominantly a function of with steroid resistance [1, 4, 7]; hence, our lower overall mortality of 6.5%, compared with 6.6–14.3% in other African reports [7, 16, 24], is not surprising. Mortality was particularly high among those with steroid resistant nephrotic syndrome who progressed to ESKD.…”

Section: Discussionsupporting

confidence: 78%

High Steroid Sensitivity among Children with Nephrotic Syndrome in Southwestern Nigeria

Ladapo

Esezobor

Lesi

2014

International Journal of Nephrology

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Recent reports from both Caucasian and black populations suggest changes in steroid responsiveness of childhood nephrotic syndrome. This study was therefore undertaken to determine the features and steroid sensitivity pattern of a cohort of black children with nephrotic syndrome. Records of children managed for nephrotic syndrome from January 2008 to April 2013 were reviewed. Details including age, response to treatment, and renal histology were analysed. There were 108 children (median age: 5.9 years, peak: 1-2 years), 90.2% of whom had idiopathic nephrotic syndrome. Steroid sensitivity was 82.8% among children with idiopathic nephrotic syndrome but 75.9% overall. Median time to remission was 7 days. Median age was significantly lower in steroid sensitive compared with resistant patients. The predominant histologic finding in resistant cases was focal segmental glomerulosclerosis (53.3%). No cases of quartan malaria nephropathy or hepatitis B virus nephropathy were diagnosed. Overall mortality was 6.5%. In conclusion, unusually high steroid sensitivity is reported among a cohort of black children. This is likely attributable to the lower age structure of our cohort as well as possible changing epidemiology of some other childhood diseases. Surveillance of the epidemiology of childhood nephrotic syndrome and corresponding modifications in practice are therefore recommended.

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Section: Discussionsupporting

confidence: 78%

High Steroid Sensitivity among Children with Nephrotic Syndrome in Southwestern Nigeria

Ladapo

Esezobor

Lesi

2014

International Journal of Nephrology

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“…Laporan lain peningkatan kreatinin terjadi pada 32,5% pasien dengan SN kelainan minimal, 40,6% pasien dengan glomerulosklerosis fokal segmental (GSFS), dan 50% pasien dengan glomerulonefritis membranoproliferatif (MPGN). 10,11 Pada penelitian kami tidak dilakukan biopsi, sehingga peningkatan kadar kreatinin tidak dibedakan berdasarkan temuan patologi anatominya.…”

Section: Pembahasanunclassified

Profil Sindrom Nefrotik pada Ruang Perawatan Anak RSUP Sanglah Denpasar

Nilawati

2016

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S indrom nefrotik (SN) merupakan kelainan ginjal terbanyak dijumpai pada anak, dengan angka kejadian 15 kali lebih banyak dibandingkan orang dewasa. Insidennya sekitar 2-3/100.000 anak per tahun, dan sebagian besar anak SN merupakan tipe sensitif terhadap pengobatan steroid yang dimasukkan sebagai kelainan minimal. [1][2][3][4] Gambaran klinis SN ditandai dengan proteinuria masif (>40mg/m 2 /jam), hipoalbuminemia (<2,5 g/ dL), edema, dan hiperlipidemia.2-3 Sebagian besar (90%) SN pada anak-anak merupakan SN yang idiopatik. Sisanya (10%) merupakan SN sekunder yang berhubungan dengan kelainan glomerulus seperti nefropati membranosa dan glomerulonefritis membranoprolifratif.Sindrom nefrotik terjadi karena peningkatan permeabilitas dinding kapiler glomerulus yang mengakibatkan proteinuria masif dan hipoalbuminemia. Kata kunci: sindrom nefrotik , bengkak, sensitif steroid, resisten steroid

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“…The increased prevalence of UTI in patients with Nephrotic syndrome are due to immunoglobulin loss in urine, 8 defective T cell function, presence ascites and relative malnutrition. 9 UTI has also been reported to adversely influence the response of patients with nephrotic syndrome to corticosteroids. 10 However McVicar et al 7 did not find any relationship between UTI and response to steroid therapy.…”

Section: Mots Clés: Enfance Syndrome Nephrotique Uti Prédominancementioning

confidence: 99%

Urinary tract infection in children with nephrotic syndrome in Kano, Nigeria

Adeleke

Asani

2009

Ann Afr Med

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Background: Nephrotic syndrome is a common childhood renal disorder; the prevalence of Urinary tract infection (UTI) in these patients is high. The increased prevalence of UTI are due to immunoglobulin loss, defective T cell function, presence of ascites and relative malnutrition. Objective: The study is to evaluate the prevalence of UTI , its etiological agents, antibiotics, sensitivity pattern and the outcome in children with nephrotic syndrome. Methods: A prospective study of all patients with diagnosis of nephrotic syndrome from January 2003 to December 2006. Urine specimen were routinely obtained by clean catch method following careful preparation urethral orifices. The specimens were processed immediately. Five millimeters (5mml) loopful of the sample were inoculated on a blood agar and CLED agar plates. Identification of the organism to species level was by using stokes disc diffusion technique. Results: Forty two patients were studied. The mean age and SEM for males was 8.2 + 0.5years and females with 7.9 + 0.8years. The age range was two to fifteen years UTI was caused predominantly by Staphylococcus aureus in 67.9%, Klebsiella species (17.9%) and Pseudomonas (14.2%). There was high invitro resistance of these organisms to nalidixic acid and ampicillin but sensitive to cefotaxime, ceftriazone and ciprofloxacin. Conclusion: It is recommend that UTI should be sought for in patients with nephrotic syndrome and treatment should be prompt and appropriate. Key words: Childhood, nephrotic syndrome, UTI, prevalenceRésumé Arrière-plan : Syndrome néphrotique est un trouble rénale enfance courant ; la prévalence des voies urinaires infections (UTI) chez ces patients est élevée. La prévalence accrue de UTI sont dues à perte immunoglobuline, fonction de la cellule T défectueux, présence de l'ascite et la malnutrition relative. Objectif: L'étude est d'évaluer la prévalence de la UTI, ses agents étiologique, les antibiotiques, motif de la sensibilité et le résultat chez les enfants avec néphrotique Syndrome. Méthodes: Une étude éventuelle de tous les patients présentant le diagnostic du syndrome nephrotique entre le janvier 2003 à décembre 2006. Le spécimen d'urine ont été par habitude obtenus par la méthode propre de crochet suivant les orifices uréthraux de préparation soigneuse. Les spécimens ont été traités immédiatement. Cinq millimètres (5mml) de loopful de l'échantillon ont été inoculés des plats de sang agar et d'agar de CLED. L'identification de l'organization aux espèces de niveau était en employant charge la technique de diffusion de disque Résultats: Quarante deux patients ont été étudiés. L'âge moyen et le SEM pour des mâles étaient 8.2 + 0.5years et femelles avec 7.9 + 0.8years. La tranche d'âge était de deux à quinze ans où UTI a été causé principalement près Staphylocoque doré dans 67.9%, espèces de klebsiella (17.9%) et pseudomonas (14.2%). Il y avait hauts résistance d'invitro de ces organizations à l'acide et à l'ampicilline nalidixic mais sensible au cefotaxime, au ceftriazone et au ciprofl...

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Childhood Nephrotic Syndrome in Ilorin

Cited by 11 publications

References 0 publications

High Steroid Sensitivity among Children with Nephrotic Syndrome in Southwestern Nigeria

High Steroid Sensitivity among Children with Nephrotic Syndrome in Southwestern Nigeria

Profil Sindrom Nefrotik pada Ruang Perawatan Anak RSUP Sanglah Denpasar

Urinary tract infection in children with nephrotic syndrome in Kano, Nigeria

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