Childhood melanoma: a clinicopathological study of 22 cases

Congenital melanocytic nevi: Clinical and histopathologic features, risk of melanoma, and clinical management

“…Indeed, in the 30 years of the Massachusetts General Hospital Pigmented Lesion Clinic, no child (younger than 20 years of age) has developed melanoma in association with a congenital nevus less than 5 cm in diameter. 45 Pigmented lesion clinics at other institutions report similar findings (Al Kopf, personal communication). This experience is similar to that reported in a study of 52 patients with melanomas that arose in congenital melanocytic nevi by Illig et al, who observed that melanoma arising in association with nevi less than 10 cm in diameter occurred only in postpubertal patients aged 18 years or older.…”

Congenital melanocytic nevi: Where are we now?

“…101,102 However, most studies show an incidence rate of melanoma in small and medium CMN of\1%. 3,5,19,[103][104][105][106][107] This compares with a general lifetime risk of MM in the United States of 1.97%. 108 Concerning medium-sized CMN, a prospective study of 230 (1.5-19.9 cm) CMN with an average follow-up of 6.7 years to an average age of 25.5 years found that no MM developed in any of the lesions.…”

Melanocytic nevi simulant of melanoma with medicolegal relevance

“…The clinical diagnosis is often that of a melanoma, but over time, most of these stiff and large nodules evolve in soft and smaller lesions and can also completely disappear. These nodular lesions in the midst of a congenital nevus are called proliferative nodules and are considered benign and must be distinguished from true nodular melanoma developed in the core of the intra-dermal portion of a congenital nevus [126]. Such benign proliferative nodules can have disparate histological features reminding one of any possible nevus variants.…”