Childhood maltreatment increases the risk of suicide attempt in schizophrenia

Hassan, Ahmed; Stuart, Elizabeth A.; Luca, Vincenzo De

doi:10.1016/j.schres.2016.05.012

Cited by 31 publications

(25 citation statements)

References 37 publications

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“…Specifically, 78.7% of participants in the suicide attempt group reported exposure to at least one type of childhood trauma that was classified as moderate or severe compared to 37.7% and 17.8% in the ideator and control groups, respectively. Such high levels of childhood trauma in suicide attempters are consistent with existing published studies (e.g., Enns et al, 2006;Hassan, Stuart & De Luca, 2016;Marshall et al, 2013;Sachiapone et al, 2007). For example, Marshall et al (2013), using the CTQ, found similarly high levels of moderate and severe childhood trauma being associated with suicide attempt in a prospective cohort study of illicit drug users.…”

Section: Accepted Manuscriptsupporting

confidence: 88%

Effects of childhood trauma on cortisol levels in suicide attempters and ideators

O’Connor

Green

Ferguson

et al. 2018

Psychoneuroendocrinology

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Section: Accepted Manuscriptsupporting

confidence: 88%

Effects of childhood trauma on cortisol levels in suicide attempters and ideators

O’Connor

Green

Ferguson

et al. 2018

Psychoneuroendocrinology

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“…However, a limited number of studies have addressed this important issue. For instance, it has been shown that among patients diagnosed with depression and psychosis, early exposures to traumatic events significantly increased the risk of suicide (de Mattos Souza et al ., 2016; Hassan et al ., 2016; Xie et al ., 2018). It has also been shown that among patients with treatment-resistant depression, being exposed to severe traumatic events in childhood significantly increases the risk of psychotic symptoms as well as the risk of suicide (Tunnard et al ., 2014), which tentatively suggests these markers interact with each other in predicting suicidal behaviors.…”

Section: Introductionmentioning

confidence: 99%

The interplay between childhood trauma, cognitive biases, psychotic-like experiences and depression and their additive impact on predicting lifetime suicidal behavior in young adults

et al. 2019

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BackgroundChildhood trauma, psychosis risk, cognition, and depression have been identified as important risk markers for suicidal behaviors. However, little is known about the interplay between these distal and proximal markers in influencing the risk of suicide. We aim to investigate the interplay between childhood trauma, cognitive biases, psychotic-like experiences (PLEs) and depression in predicting suicidal behaviors in a non-clinical sample of young adults.MethodsIn total, 3495 young adults were recruited to an online computer-assisted web interview. We used the Prodromal Questionnaire to assess PLEs. Childhood trauma was assessed with the Traumatic Experience Checklist (three items) and Childhood Experience of Care and Abuse Questionnaire (CECA.Q, three items). Cognitive biases were assessed with a short version of the Davos Assessment of Cognitive Biases Scale. Suicidality, psychiatric diagnoses, and substance use were screened with a self-report questionnaire.ResultsChildhood trauma, as well as PLEs, was associated with an approximately five-fold increased risk of suicidal thoughts and plans as well as suicide attempts. Participants with depression were six times more likely to endorse suicidal behaviors. Path analysis revealed that PLEs, depression and cognitive biases are significant mediators of the relationship between trauma and suicidal behaviors. The model explained 44.6% of the variance in lifetime suicidality.ConclusionsCognitive biases, PLEs, and depression partially mediate the relationship between childhood trauma and suicidal behaviors. The interplay between distal and proximal markers should be recognized and become part of clinical screening and therapeutic strategies for preventing risk of suicidality.

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“…In both general population and psychiatric samples, childhood adversities and trauma are one of the main psychological predictors of suicidality ( 6 – 8 ). While suicidality seems to be related to childhood adversities and trauma in patients with first-episode psychosis ( 9 , 10 ), this link has not yet been studied sufficiently in CHR-patients. Furthermore, most previous studies in general population, patient and in particular in CHR-samples have investigated potential predictors of suicidality in isolation without analyzing their interplay and their relative contributions to suicidality simultaneously.…”

Section: Introductionmentioning

confidence: 99%

Mediators Linking Childhood Adversities and Trauma to Suicidality in Individuals at Risk for Psychosis

et al. 2017

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Suicidality is highly prevalent in patients at clinical high risk (CHR) for psychosis. Childhood adversities and trauma are generally predictive of suicidality. However, the differential effects of adversity/trauma-domains and CHR-criteria, i.e., ultra-high risk and basic symptom criteria, on suicidality remain unclear. Furthermore, the underlying mechanisms and, thus, worthwhile targets for suicide-prevention are still poorly understood. Therefore, structural equation modeling was used to test theory-driven models in 73 CHR-patients. Mediators were psychological variables, i.e., beliefs about one’s own competencies as well as the controllability of events and coping styles. In addition, symptomatic variables (depressiveness, basic symptoms, attenuated psychotic symptoms) were hypothesized to mediate the effect of psychological mediators on suicidality as the final outcome variable. Results showed two independent pathways. In the first pathway, emotional and sexual but not physical adversity/trauma was associated with suicidality, which was mediated by dysfunctional competence/control beliefs, a lack of positive coping-strategies and depressiveness. In the second pathway, cognitive basic symptoms but not attenuated psychotic symptoms mediated the relationship between trauma/adversity and suicidality. CHR-patients are, thus, particularly prone to suicidality if adversity/trauma is followed by the development of depressiveness. Regarding the second pathway, this is the first study showing that adversity/trauma led to suicidality through an increased risk for psychosis as indicated by cognitive basic symptoms. As insight is generally associated with suicidality, this may explain why self-experienced basic symptoms increase the risk for it. Consequently, these mediators should be monitored regularly and targeted by integrated interventions as early as possible to enhance resilience against suicidality.

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Childhood maltreatment increases the risk of suicide attempt in schizophrenia

Cited by 31 publications

References 37 publications

Effects of childhood trauma on cortisol levels in suicide attempters and ideators

Effects of childhood trauma on cortisol levels in suicide attempters and ideators

The interplay between childhood trauma, cognitive biases, psychotic-like experiences and depression and their additive impact on predicting lifetime suicidal behavior in young adults

Mediators Linking Childhood Adversities and Trauma to Suicidality in Individuals at Risk for Psychosis

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